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    G-oalpha47A G protein oalpha 47A [ Drosophila melanogaster ]

    Gene ID: 36104, updated on 10-May-2012
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    Summary

    Official Symbol
    G-oalpha47Aprovided by Flybase
    Official Full Name
    G protein oalpha 47Aprovided by Flybase
    Primary source
    FLYBASE:FBgn0001122
    Locus tag
    Dmel_CG2204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha(o); bkh; Bkh; CG2204; DGalpha0; DGalpha[[o]]; dgo; dgoalpha; DG[[o]]; Dmel\CG2204; DROGPAD; G(o)alpha47A; G-alpha-47A; G-oalpha; G-oalpha47a; Galpha47A; Galphao; Galphao47A; Galpha[[047A]]; Galpha[[0]]; Galpha[[o]]; Go; Go-alpha; Goa; Goalpha; G[[oalpha]]; G[[o]]alpha
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    Genomic context

    Location :
    47A7-47A9
    Sequence :
    Chromosome: 2R; NT_033778.3 (6325466..6351297)
    See G-oalpha47A in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene Ran-binding protein M Neighboring gene CG12895 gene product from transcript CG12895-RA Neighboring gene CG18377 gene product from transcript CG18377-RA Neighboring gene CG12892 gene product from transcript CG12892-RA Neighboring gene CG11777 gene product from transcript CG11777-RA Neighboring gene withered

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Identification of an in vitro interaction between an insect immune suppressor protein (CrV2) and G alpha proteins. Cooper TH, et al. J Biol Chem, 2011 Mar 25. PMID 21233205.
    3. Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Dahdal D, et al. Neuron, 2010 Dec 9. PMID 21145008.
    4. Go α is involved in sugar perception in Drosophila. Bredendiek N, et al. Chem Senses, 2011 Jan. PMID 20940344.
    5. Competing activities of heterotrimeric G proteins in Drosophila wing maturation. Katanayeva N, et al. PLoS One, 2010 Aug 23. PMID 20808795.

    See all (71) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Go is required for maximal physiological responses to multiple odorants in Drosophila, and olfactory receptor channel function and G-protein signaling are required for odor responsiveness.
      Title: Go contributes to olfactory reception in Drosophila melanogaster.
    2. Study shows that G-oalpha47A and Gbeta13F cooperate with Ggamma1 to maintain cardiac integrity in Drosophila.
      Title: Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.
    3. The roles for Galpha(o) subunit (Go) in mediating the two distinct pathways transduced by Fz receptors in Drosophila.
      Title: Trimeric G protein-dependent frizzled signaling in Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61922 BioGRID:67857 CG13625    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:60757 CG9426    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:66229 CG9837    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:61124 Grip71    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:60798 Hsp60D    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:59646 Rab5    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:67703 RpS3    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:57861 VhaAC39-1    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:65542 knrl    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:72799 raps    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:61922 BioGRID:61272 rtGEF    BioGRID  PubMed Two-hybrid 
    BioGRID:61922 BioGRID:60047 slam    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the G-oalpha47A gene: The G-oalpha47A gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    		  
    GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    GTPase activity NAS
    Non-traceable Author Statement
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    G-protein coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		  
    Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    heart development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sensory perception of sweet taste IMP
    Inferred from Mutant Phenotype
    more info
    		  
    septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    heterotrimeric G-protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    heterotrimeric G-protein complex NAS
    Non-traceable Author Statement
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    CG2204 gene product from transcript CG2204-RB
    Names
    CG2204-PA
    CG2204-PB
    CG2204-PC
    CG2204-PD
    CG2204-PE
    CG2204-PF
    CG2204-PG
    CG2204-PH
    CG2204-PI
    G protein oalpha 47A
    G-oalpha47A-PA
    G-oalpha47A-PB
    G-oalpha47A-PC
    G-oalpha47A-PD
    G-oalpha47A-PE
    G-oalpha47A-PF
    G-oalpha47A-PG
    G-oalpha47A-PH
    G-oalpha47A-PI
    brokenheart
    brokenhearted
    drogpad
    n
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      6325466..6351297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165772.3 → NP_724934.1  G protein oalpha 47A, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087359, FBtr0088264
      Conserved Domains (2) summary
      smart00275
      Location:13 – 352
      Blast Score: 1413
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. NM_165773.2 → NP_724935.1  G protein oalpha 47A, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FF70
      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087360, FBtr0088265
      Conserved Domains (2) summary
      smart00275
      Location:19 – 352
      Blast Score: 1395
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1522
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    3. NM_176124.2 → NP_788304.1  G protein oalpha 47A, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087362, FBtr0088267
      Conserved Domains (2) summary
      smart00275
      Location:13 – 352
      Blast Score: 1413
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    4. NM_176125.2 → NP_788305.1  G protein oalpha 47A, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087363, FBtr0088268
      Conserved Domains (2) summary
      smart00275
      Location:13 – 352
      Blast Score: 1413
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    5. NM_206080.1 → NP_995802.1  G protein oalpha 47A, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0089315, FBtr0088271
      Conserved Domains (2) summary
      smart00275
      Location:13 – 352
      Blast Score: 1413
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    6. NM_176126.2 → NP_788306.1  G protein oalpha 47A, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087364, FBtr0088269
      Conserved Domains (2) summary
      smart00275
      Location:13 – 352
      Blast Score: 1413
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    7. NM_176127.2 → NP_788307.1  G protein oalpha 47A, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087365, FBtr0088270
      Conserved Domains (2) summary
      smart00275
      Location:13 – 352
      Blast Score: 1413
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    8. NM_078960.4 → NP_523684.2  G protein oalpha 47A, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FF70
      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087361, FBtr0088266
      Conserved Domains (2) summary
      smart00275
      Location:19 – 352
      Blast Score: 1395
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1522
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    9. NM_206079.1 → NP_995801.1  G protein oalpha 47A, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FF70
      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0089316, FBtr0088272
      Conserved Domains (2) summary
      smart00275
      Location:19 – 352
      Blast Score: 1395
      G_alpha; G protein alpha subunit
      cd00066
      Location:34 – 348
      Blast Score: 1522
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF58789.1
    genomic AE013599.4 AAO41421.1
    mRNA M29731.1 AAA28580.1
    genomic AE013599.4 AAO41422.1
    genomic AE013599.4 AAO41423.1
    genomic AE013599.4 AAS64872.1
    genomic AE013599.4 AAO41420.1
    mRNA M30151.1 AAA28584.1
    mRNA M86660.1 AAA28577.1
    mRNA M29602.1 AAA28587.1
    mRNA BT046134.2 ACK77603.1
    mRNA M29732.1 AAA28581.1
    mRNA AY121631.1 AAM51958.1
    genomic AE013599.4 AAS64873.1
    genomic AE013599.4 AAF58790.1
    genomic AE013599.4 AAM68759.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    RGFFO2.1 GenPept
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    Additional Links

    Gene LinkOut

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