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Etnk2 ethanolamine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360843, updated on 13-Apr-2024

Summary

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Official Symbol
Etnk2provided by RGD
Official Full Name
ethanolamine kinase 2provided by RGD
Primary source
RGD:1305304
See related
AllianceGenome:RGD:1305304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EKI 2
Summary
Predicted to enable ethanolamine kinase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process and phosphorylation. Predicted to act upstream of or within in utero embryonic development; placenta development; and post-embryonic development. Predicted to be active in cytoplasm. Orthologous to human ETNK2 (ethanolamine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 399.6), Adrenal (RPKM 141.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47362964..47381100)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (44811012..44829052)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50481178..50498991, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene uncharacterized LOC102550525 Neighboring gene renin Neighboring gene SRY-box transcription factor 13 Neighboring gene uncharacterized LOC103692077

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. Tian Y, et al. J Biol Chem, 2006 Sep 22. PMID 16861741
  2. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables choline kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ethanolamine kinase 2
Names
ethanolamine kinase-like protein
NP_001406523.1
XP_063128534.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419594.1 → NP_001406523.1  ethanolamine kinase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    D3ZRW8, D4A6J5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    47362964..47381100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272464.1 → XP_063128534.1  ethanolamine kinase 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108343.1: Suppressed sequence

    Description
    NM_001108343.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZRW8.1 GenPept UniProtKB/Swiss-Prot:D3ZRW8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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