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    KCNQ KCNQ potassium channel [ Drosophila melanogaster ]

    Gene ID: 36071, updated on 10-May-2012
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    Summary

    Official Symbol
    KCNQprovided by Flybase
    Official Full Name
    KCNQ potassium channelprovided by Flybase
    Primary source
    FLYBASE:FBgn0033494
    Locus tag
    Dmel_CG33135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12215; CG12915; CG33135; dKCNQ; DKCNQ; Dmel\CG33135; kcnq1
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    Genomic context

    Location :
    46F3-46F5
    Sequence :
    Chromosome: 2R; NT_033778.3 (6033402..6079899, complement)
    See KCNQ in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene gemini Neighboring gene CG12917 gene product from transcript CG12917-RB Neighboring gene ncRNA Neighboring gene CG18011 gene product from transcript CG18011-RA Neighboring gene Odorant receptor 46a Neighboring gene CG12214 gene product from transcript CG12214-RB Neighboring gene CG34221 gene product from transcript CG34221-RB Neighboring gene Hormone receptor-like in 46 Neighboring gene CG12912 gene product from transcript CG12912-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. Cavaliere S, et al. PLoS One, 2011. PMID 21915266.
    2. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Reddy BA, et al. Mol Cell Biol, 2010 Nov. PMID 20733004.
    3. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351.
    4. Partial loss of GATA factor Pannier impairs adult heart function in Drosophila. Qian L, et al. Hum Mol Genet, 2009 Sep 1. PMID 19494035.
    5. Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006. Tountas NA, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690062.

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that Drosophila KCNQ (dKCNQ) is a slowly activating and slowly-deactivating K(+) current open at sub-threshold potentials that has similar properties to neuronal KCNQ2/3 with some features of the cardiac KCNQ1/KCNE1.
      Title: Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
    2. A maternal contribution of KCNQ protein and/or mRNA is essential for early embryonic development
      Title: A Drosophila KCNQ channel essential for early embryonic development.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61893 BioGRID:69379 And    BioGRID  PubMed Two-hybrid 
    BioGRID:61893 BioGRID:57616 CG11638    BioGRID  PubMed Two-hybrid 
    BioGRID:61893 BioGRID:72825 CG18806    BioGRID  PubMed Two-hybrid 
    BioGRID:61893 BioGRID:62106 Cam    BioGRID  PubMed Two-hybrid 
    BioGRID:61893 BioGRID:66520 Jupiter    BioGRID  PubMed Two-hybrid 
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    General gene information

    Pathways from BioSystems

    mobile_element

    • Loc: c6073548-6064440 mobile_element_type = transposon:roo{}796

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    voltage-gated potassium channel activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG33135 gene product from transcript CG33135-RD
    Names
    CG33135-PC
    CG33135-PD
    CG33135-PE
    CG33135-PF
    KCNQ potassium channel
    KCNQ-PC
    KCNQ-PD
    KCNQ-PE
    KCNQ-PF
    KCNQ-type K[+] channel
    polyclonal
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      6033402..6079899, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144160.2 → NP_001137632.1  KCNQ potassium channel, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZR3
      Related
      FBpp0289111, FBtr0299833
      Conserved Domains (3) summary
      pfam00520
      Location:76 – 259
      Blast Score: 252
      Ion_trans; Ion transport protein
      pfam03520
      Location:365 – 521
      Blast Score: 605
      KCNQ_channel; KCNQ voltage-gated potassium channel
      cl11596
      Location:187 – 260
      Blast Score: 162
      Ion_trans_2; Ion channel

    2. NM_176119.4 → NP_788299.3  KCNQ potassium channel, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5PXF9
      Related
      FBpp0290658, FBtr0301443
      Conserved Domains (3) summary
      pfam00520
      Location:110 – 293
      Blast Score: 254
      Ion_trans; Ion transport protein
      pfam03520
      Location:399 – 555
      Blast Score: 603
      KCNQ_channel; KCNQ voltage-gated potassium channel
      cl11596
      Location:221 – 294
      Blast Score: 163
      Ion_trans_2; Ion channel

    3. NM_176120.4 → NP_788300.3  KCNQ potassium channel, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z856
      Related
      FBpp0290659, FBtr0301444
      Conserved Domains (3) summary
      pfam00520
      Location:110 – 293
      Blast Score: 260
      Ion_trans; Ion transport protein
      pfam03520
      Location:555 – 740
      Blast Score: 633
      KCNQ_channel; KCNQ voltage-gated potassium channel
      cl11596
      Location:221 – 294
      Blast Score: 165
      Ion_trans_2; Ion channel

    4. NM_001144159.1 → NP_001137631.1  KCNQ potassium channel, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZR4
      Related
      FBpp0289110, FBtr0299832
      Conserved Domains (3) summary
      pfam00520
      Location:110 – 293
      Blast Score: 249
      Ion_trans; Ion transport protein
      pfam03520
      Location:399 – 555
      Blast Score: 601
      KCNQ_channel; KCNQ voltage-gated potassium channel
      cl11596
      Location:221 – 294
      Blast Score: 162
      Ion_trans_2; Ion channel
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 ACL83086.1
    mRNA AY823300.1 AAV70986.1
    genomic AE013599.4 AAF58830.4
    mRNA AY823301.1 AAV70987.1
    genomic AE013599.4 AAF58829.5
    genomic AE013599.4 ACL83085.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PXF9.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content