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    14-3-3zeta [ Drosophila melanogaster ]

    Gene ID: 36059, updated on 10-May-2012
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    Summary

    Official Symbol
    14-3-3zetaprovided by Flybase
    Primary source
    FLYBASE:FBgn0004907
    Locus tag
    Dmel_CG17870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    14-3-3; 14-3-3 zeta; 14-3-3-zeta; 14-3-3ZETA; 2G1; 4-3-3 zeta; 5.11; 549; BEST:GH05075; CG17870; D14-3-3; d14-3-3zeta; D14-3-3zeta; Dmel\CG17870; K; l(2)07103; l(2)46CFe; l(2)46Ee; leo; Leo; LEO; par-5; Par-5; PAR-5; PAR5
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    Genomic context

    Location :
    46E6-46E8
    Sequence :
    Chromosome: 2R; NT_033778.3 (5987184..5997192)
    See 14-3-3zeta in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG2269 gene product from transcript CG2269-RD Neighboring gene sugar transporter 4 Neighboring gene Ribosomal protein LP0-like Neighboring gene Jun-related antigen Neighboring gene Phosphofructokinase Neighboring gene CG11866 gene product from transcript CG11866-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity. Shandala T, et al. J Cell Sci, 2011 Jul 1. PMID 21670199.
    3. CENP-C is a structural platform for kinetochore assembly. Przewloka MR, et al. Curr Biol, 2011 Mar 8. PMID 21353555.
    4. Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes. Montembault E, et al. J Cell Biol, 2010 Dec 27. PMID 21187330.
    5. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518.

    See all (113) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Hpo signaling inhibited Yki nuclear localization and activity by phosphorylating Yki and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki activity through modulating its subcellular localization.
      Title: Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms.
    2. in vivo 14-3-3zeta monomer properties and functionality
      Title: Dimerization is essential for 14-3-3zeta stability and function in vivo.
    3. Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
      Title: A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3zeta gene.
    4. monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
      Title: Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel.
    5. These observations provide the first direct evidence that a 14-3-3 protein functions as a stress-induced molecular chaperone that dissolves and renaturalizes thermal-aggregated proteins.
      Title: A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_476885.2 NP_477349.1 Slob    BIND  PubMed Slob interacts with 14-3-3-zeta in the dSlo/Slob/14-3-3-zeta complex. 
    NP_724885.1 NP_732309.1 14-3-3epsilon    BIND  PubMed 14-3-3-epsilon interacts with LEO. 
    NP_724885.1 NP_523383.2 baz    BIND  PubMed Bazooka interacts with LEO. 
    NP_724885.1 NP_995900.1 par-1    BIND  PubMed PAR-1 interacts with LEO. 
    NP_724885.1 CAB72239.1 phl    BIND  PubMed Raf interacts with LEO. 
    BioGRID:61887 BioGRID:67207 14-3-3epsilon    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:61887 BioGRID:59312 AnnX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61887 BioGRID:58422 Atg8a    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:59744 CG12400    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:58395 CG12641    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:65228 CG13731    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:67667 CG13838    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:62860 CG15109    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:60601 CG16854    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:64510 CG3335    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:78141 CG40127    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:66862 CG43162    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:62794 CG5174    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:67091 CG8907    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:63695 CG9184    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:67425 Cpr92F    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:58662 HDAC4    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:68954 Idh    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:60082 Oatp26F    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:72483 PebIII    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:68919 RpL8    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:59470 RpLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:68512 Sap-r    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:60181 Slob    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:61887 BioGRID:61430 Src42A    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61887 BioGRID:67788 Syx1A    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:58696 Tango2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61887 BioGRID:60947 Tektin-A    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:57861 VhaAC39-1    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:68580 awd    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61887 BioGRID:60352 borr    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61887 BioGRID:72865 chico    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61887 BioGRID:69557 csw    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:68590 faf    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61887 BioGRID:65326 ftz-f1    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:58878 mRpS30    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:64240 mei-P22    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:77411 mon2    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:65007 mrn    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:62356 phyl    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:58570 regucalcin    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61887 BioGRID:67796 sec10    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:59774 sec5    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:65184 sinah    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:67865 slo    BioGRID  PubMed Reconstituted Complex 
    BioGRID:61887 BioGRID:68777 sol    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:61589 tor    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61887 BioGRID:64779 tral    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:64781 ver    BioGRID  PubMed Two-hybrid 
    BioGRID:61887 BioGRID:67936 vig2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the 14-3-3zeta gene: The 14-3-3zeta gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase C inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein kinase C inhibitor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    tryptophan hydroxylase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    		  
    activation of tryptophan 5-monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    		  
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye photoreceptor cell differentiation NAS
    Non-traceable Author Statement
    more info
    		  
    germarium-derived oocyte fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    learning or memory NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    olfactory learning NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    oocyte microtubule cytoskeleton polarization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG17870 gene product from transcript CG17870-RB
    Names
    14-3-3zeta
    14-3-3zeta-PA
    14-3-3zeta-PB
    14-3-3zeta-PC
    14-3-3zeta-PD
    14-3-3zeta-PE
    14-3-3zeta-PF
    14-3-3zeta-PG
    14-3-3zeta-PH
    14-3-3zeta-PI
    14-3-3zeta-PJ
    CG17870-PA
    CG17870-PB
    CG17870-PC
    CG17870-PD
    CG17870-PE
    CG17870-PF
    CG17870-PG
    CG17870-PH
    CG17870-PI
    CG17870-PJ
    D14 3 3 protein
    LEONARDO
    Leonardo-13-3-3
    complementation group K
    leonardo 14-3-3
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      5987184..5997192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165742.1 → NP_724886.1  14-3-3zeta, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0087500, FBtr0088412
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1033
      14-3-3; 14-3-3 domain

    2. NM_165740.2 → NP_724884.1  14-3-3zeta, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0087503, FBtr0088415
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1037
      14-3-3; 14-3-3 domain

    3. NM_206070.1 → NP_995792.1  14-3-3zeta, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0089337, FBtr0088418
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1033
      14-3-3; 14-3-3 domain

    4. NM_165744.2 → NP_724888.2  14-3-3zeta, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0087504, FBtr0088416
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1032
      14-3-3; 14-3-3 domain

    5. NM_165745.2 → NP_724889.2  14-3-3zeta, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0087505, FBtr0088417
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1033
      14-3-3; 14-3-3 domain

    6. NM_057537.3 → NP_476885.2  14-3-3zeta, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0087502, FBtr0088414
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1037
      14-3-3; 14-3-3 domain

    7. NM_165743.2 → NP_724887.2  14-3-3zeta, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0089338, FBtr0088419
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1032
      14-3-3; 14-3-3 domain

    8. NM_001014515.1 → NP_001014515.1  14-3-3zeta, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0099540, FBtr0100183
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1037
      14-3-3; 14-3-3 domain

    9. NM_165741.2 → NP_724885.1  14-3-3zeta, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0087501, FBtr0088413
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1033
      14-3-3; 14-3-3 domain

    10. NM_001014516.1 → NP_001014516.1  14-3-3zeta, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29310
      Related
      FBpp0099539, FBtr0100182
      Conserved Domains (1) summary
      cl02098
      Location:5 – 234
      Blast Score: 1033
      14-3-3; 14-3-3 domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF58842.4
    genomic AE013599.4 AAX52716.1
    genomic AE013599.4 AAF58843.3
    genomic AE013599.4 AAM71062.1
    mRNA BT099909.1 ACX32980.1
    genomic AE013599.4 AAS64884.1
    genomic Y12573.1 CAA73153.1
    genomic AE013599.4 AAM71060.1
    genomic Y12573.1 CAA73152.1
    genomic AE013599.4 AAM71061.1
    mRNA BT088441.1 ACR44245.1
    mRNA M77518.1 AAA28324.1
    mRNA BT082022.1 ACO72859.1
    genomic AE013599.4 AAX52715.1
    genomic AE013599.4 AAM71064.2
    genomic AE013599.4 AAM71063.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAM71063.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content