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mxb myxovirus (influenza) resistance B [ Danio rerio (zebrafish) ]

Gene ID: 360143, updated on 27-Mar-2024

Summary

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Official Symbol
mxbprovided by ZNC
Official Full Name
myxovirus (influenza) resistance Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030721-6
See related
Ensembl:ENSDARG00000004953 AllianceGenome:ZFIN:ZDB-GENE-030721-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within response to virus. Predicted to be active in several cellular components, including cytoplasm; microtubule; and nucleus. Is expressed in head kidney. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1) and MX2 (MX dynamin like GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (7574224..7603573, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (6890788..6920140, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene myxovirus (influenza) resistance A Neighboring gene ephrin-B2b Neighboring gene arginine and glutamate rich 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of the functional regions of the viral haemorrhagic septicaemia virus (VHSV) NV protein: Variants that improve function. Chinchilla B, et al. Fish Shellfish Immunol, 2017 Nov. PMID 28882802
  2. Behavioural fever in zebrafish larvae. Rey S, et al. Dev Comp Immunol, 2017 Feb. PMID 27670815
  3. Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways. Nie L, et al. Dev Comp Immunol, 2014 Mar. PMID 24183820
  4. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Zou PF, et al. Fish Shellfish Immunol, 2015 Mar. PMID 25524497
  5. Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN. Robertsen B, et al. Dev Comp Immunol, 2019 Jan. PMID 30195710

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced GTP-binding protein MxB
Names
IFN-inducible antiviral protein MxB
interferon-inducible MxB protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128672.1 → NP_001122144.1  interferon-induced GTP-binding protein MxB

    See identical proteins and their annotated locations for NP_001122144.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162700
    UniProtKB/Swiss-Prot
    Q800G8
    UniProtKB/TrEMBL
    B3DH90
    Related
    ENSDARP00000128925.1, ENSDART00000009315.11
    Conserved Domains (3) summary
    smart00302
    Location:460 → 548
    GED; Dynamin GTPase effector domain
    cd08771
    Location:1 → 230
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:151 → 432
    Dynamin_M; Dynamin central region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    7574224..7603573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305797.3 → XP_009304072.1  interferon-induced GTP-binding protein MxB isoform X1

    UniProtKB/Swiss-Prot
    Q800G8
    UniProtKB/TrEMBL
    A0A8M3AXE3, B8JKI4
    Related
    ENSDARP00000100431.2, ENSDART00000110696.3
    Conserved Domains (3) summary
    smart00302
    Location:537 → 625
    GED; Dynamin GTPase effector domain
    cd08771
    Location:35 → 307
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:228 → 509
    Dynamin_M; Dynamin central region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q800G8.2 GenPept UniProtKB/Swiss-Prot:Q800G8

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