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IRF2BP2 interferon regulatory factor 2 binding protein 2 [ Homo sapiens (human) ]

Gene ID: 359948, updated on 26-May-2016
Official Symbol
IRF2BP2provided by HGNC
Official Full Name
interferon regulatory factor 2 binding protein 2provided by HGNC
Primary source
HGNC:HGNC:21729
See related
Ensembl:ENSG00000168264 HPRD:17160; MIM:615332; Vega:OTTHUMG00000037981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1q42.3
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (234604269..234609525, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (234740015..234745271, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TAR (HIV-1) RNA binding protein 1 Neighboring gene long intergenic non-protein coding RNA 1354 Neighboring gene long intergenic non-protein coding RNA 184 Neighboring gene uncharacterized LOC101927787 Neighboring gene uncharacterized LOC105373207

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC72189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
interferon regulatory factor 2-binding protein 2
Names
IRF-2-binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077397.1NP_001070865.1  interferon regulatory factor 2-binding protein 2 isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B).
    Source sequence(s)
    AY278024, BC020516, BE408503, CD640986
    Consensus CDS
    CCDS41475.1
    UniProtKB/Swiss-Prot
    Q7Z5L9
    Related
    ENSP00000355569, OTTHUMP00000036087, ENST00000366610, OTTHUMT00000092704
    Conserved Domains (1) summary
    pfam11261
    Location:1164
    IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
  2. NM_182972.2NP_892017.2  interferon regulatory factor 2-binding protein 2 isoform A

    See identical proteins and their annotated locations for NP_892017.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AY278023, BC020516, BE408503, CD640986
    Consensus CDS
    CCDS1602.1
    UniProtKB/Swiss-Prot
    Q7Z5L9
    Related
    ENSP00000355568, OTTHUMP00000036088, ENST00000366609, OTTHUMT00000092705
    Conserved Domains (1) summary
    pfam11261
    Location:1164
    IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    234604269..234609525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    236012268..236017524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)