IL13 interleukin 13 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: IL13provided by HGNC
Official Full Name: interleukin 13provided by HGNC
Primary source: HGNC:5973
See related: Ensembl:ENSG00000169194; HPRD:00981; MIM:147683; Vega:OTTHUMG00000059723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P600; IL-13
Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 5q31

Sequence :: Chromosome: 5; NC_000005.9 (131993865..131996801)

See IL13 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy
Title: Combining gene expression microarray- and cluster analysis with sequence-based predictions to identify regulators of IL-13 in allergy.
there is no association between IL-13 gene polymorphisms (at position -1055C/T and +2044GI A) and susceptibility of the patients to squamous cell carcinoma of head and neck.
Title: Interleukin-13 gene polymorphisms at -1055 C/T and +2044 G/A positions in patients with squamous cell carcinoma of head and neck.
We observed large numbers of CD8(+) T cells producing IL-13, IFN-gamma, and IL-22 in atopic dermatitis and psoriasis.
Title: CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22.
IL13 rs20541 A allele [assuming recessive model; odds ratio (OR) = 3.38, 95% CI: (1.63-7.00)] showed association with development of non-atopic hand eczema.
Title: Association between non-atopic hand eczema and interleukin-13 gene polymorphism in Taiwanese nursing population.
macrophage interleukin-13 receptor has a role in foam cell formation through alphaMbeta2 integrin interference
Title: From macrophage interleukin-13 receptor to foam cell formation: mechanisms for αMβ2 integrin interference.
IL13 rs20541 polymorphism contributes to susceptibility to cancer, especially for glioma; and the IL13 rs1800925 polymorphism may be associated with glioma risk.
Title: Association between IL13 gene polymorphisms and susceptibility to cancer: a meta-analysis.
Changes in tumor proliferation, survival, and metastatic capability have all been ascribed to IL-4 and/or IL-13 action.
Title: Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.
Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells
Title: Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.
Concentrations of IL-4, IL-13 and IFN-gamma were measured in serum samples of 88 subjects with asthma.
Title: Serum levels of interleukin-13 and interferon-gamma from adult patients with asthma in Mysore.
Findings suggest that TGFbeta and IL-13 play a synergistic role in the pathogenesis of fistulae in Crohn's disease.
Title: Interleukin-13 and transforming growth factor β synergise in the pathogenesis of human intestinal fistulae.

Submit: New GeneRIF Correction See all (298)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.

A large-scale, consortium-based genomewide association study of asthma.

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.

Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces IL-4 and IL-13 releases from human basophils through its interaction with the VH3 region of IgE	PubMed
	env	HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs	PubMed
Tat, p14	tat	HIV-1 Tat induces IL-4 and IL-13 release from basophils, leading to dysregulation of the IgE/Fc epsilon RI network	PubMed
pol	gag-pol	IL-13 can act on macrophages both before and after HIV-1 infection to interfere with virus replication by blocking the completion of reverse transcription, decreasing virus production, and reducing the infectivity of the progeny virions	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P35225	P78552	IL13RA1	HPRD	PubMed
P35225	Q14627	IL13RA2	HPRD	PubMed
P35225	P24394	IL4R	HPRD	PubMed
P35225	P27986	PIK3R1	HPRD	PubMed
P35225	P19320	VCAM1	HPRD	PubMed
BioGRID:109810	BioGRID:109779	IL4	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Asthma, organism-specific biosystem (from KEGG)
Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
Asthma, conserved biosystem (from KEGG)
Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
Glucocorticoid receptor regulatory network, organism-specific biosystem
Glucocorticoid receptor regulatory network
IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
IL12 signaling mediated by STAT4, organism-specific biosystem
IL12 signaling mediated by STAT4
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

General gene information

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Markers

ECD09780 (e-PCR)
- UniSTS:290821

ECD10847 (e-PCR)
- UniSTS:291886

ECD09846 (e-PCR)
- UniSTS:290887

stSG601429 (e-PCR)
- UniSTS:444236

ECD00324 (e-PCR)
- UniSTS:281437

IL13_148 (e-PCR)
- UniSTS:277363

PMC356970P3 (e-PCR)
- UniSTS:273285

ECD05278 (e-PCR)
- UniSTS:286344

NoName (e-PCR)
- UniSTS:482731

REN71151 (e-PCR)
- UniSTS:395951

REN71152 (e-PCR)
- UniSTS:395952

REN71153 (e-PCR)
- UniSTS:395953

REN71154 (e-PCR)
- UniSTS:395954

REN71155 (e-PCR)
- UniSTS:395955

REN71156 (e-PCR)
- UniSTS:395956

REN71157 (e-PCR)
- UniSTS:395957

REN71158 (e-PCR)
- UniSTS:395958

REN71159 (e-PCR)
- UniSTS:395959

REN71160 (e-PCR)
- UniSTS:395960

REN71161 (e-PCR)
- UniSTS:395961

REN71162 (e-PCR)
- UniSTS:395962

REN71163 (e-PCR)
- UniSTS:395963

REN71164 (e-PCR)
- UniSTS:395964

REN71165 (e-PCR)
- UniSTS:395965

REN71166 (e-PCR)
- UniSTS:395966

REN71167 (e-PCR)
- UniSTS:395967

REN71168 (e-PCR)
- UniSTS:395968

REN71169 (e-PCR)
- UniSTS:395969

REN71170 (e-PCR)
- UniSTS:395970

REN71171 (e-PCR)
- UniSTS:395971

REN71172 (e-PCR)
- UniSTS:395972

REN71173 (e-PCR)
- UniSTS:395973

ECD09979 (e-PCR)
- UniSTS:291019

D5S2410 (e-PCR)
- UniSTS:76255

Genotypes

See IL13 SNP Geneview Report
See IL13 SNP Genotype Report
See IL13 SNP Variation Viewer Report

Homology

Homologs of the IL13 gene: The IL13 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
interleukin-13 receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell-cell signaling	IC Inferred by Curator more info	PubMed
cellular component movement	TAS Traceable Author Statement more info	PubMed
cellular response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
negative regulation of lung ciliated cell differentiation	NAS Non-traceable Author Statement more info
negative regulation of transforming growth factor beta production	IEA Inferred from Electronic Annotation more info
positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of connective tissue growth factor production	IEA Inferred from Electronic Annotation more info
positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
positive regulation of lung goblet cell differentiation	NAS Non-traceable Author Statement more info
positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
positive regulation of pancreatic stellate cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of tyrosine phosphorylation of Stat6 protein	IEA Inferred from Electronic Annotation more info
regulation of proton transport	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to nicotine	IEA Inferred from Electronic Annotation more info
signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
extracellular region	IDA Inferred from Direct Assay more info
extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: interleukin-13

Names: interleukin-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012090.1 RefSeqGene

Range

5001..7937

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002188.2 → NP_002179.2 interleukin-13 precursor

Status: REVIEWED

Source sequence(s)

X69079

Consensus CDS

CCDS4157.1

UniProtKB/Swiss-Prot

P35225

Related

ENSP00000304915, OTTHUMP00000066048, ENST00000304506, OTTHUMT00000132782

Conserved Domains (1) summary

smart00190
Location:20 – 145
Blast Score: 357

IL4_13; Interleukins 4 and 13

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p10 Primary Assembly

Range

131993865..131996801

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

127186169..127189105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018916.1 Alternate CHM1_1.0

Range

132270711..132273647

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01068803.1 (26419..29355)	None
genomic	AC004039.1 (45621..48557)	None
genomic	AF172149.1	None
genomic	AF172150.1	None
genomic	AF193838.1	None
genomic	AF193839.1	None
genomic	AF193840.1	None
genomic	AF377331.2	AAK53823.1
genomic	AF416600.1	None
genomic	AMYH01015616.1 (140009..142945)	None
genomic	AY008331.1	None
genomic	AY008332.1	None
genomic	CH471062.2	EAW62324.1
		EAW62325.1
		EAW62326.1
		EAW62327.1
genomic	HI573912.1	CBX47445.1
genomic	L13029.1	None
genomic	L42079.1	None
genomic	L42080.1	None
genomic	U10307.1	AAA83738.1
genomic	U31120.1	AAB01681.1
mRNA	AF043334.1	AAC03535.1
mRNA	BC096138.3	AAH96138.1
mRNA	BC096139.1	AAH96139.1
mRNA	BC096140.3	AAH96140.1
mRNA	BC096141.1	AAH96141.2
mRNA	L06801.1	AAA36107.1
mRNA	X69079.1	CAA48823.1
		CAA48824.1