IL13 interleukin 13 [Homo sapiens] - Gene

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Summary

Official Symbol: IL13provided by HGNC
Official Full Name: interleukin 13provided by HGNC
Primary source: HGNC:5973
See related: Ensembl:ENSG00000169194; HPRD:00981; MIM:147683; Vega:OTTHUMG00000059723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789
Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q31

Sequence :: Chromosome: 5; NC_000005.9 (131993865..131996801)

See IL13 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

there was no significant association of the IL13 and IL4RA polymorphisms with mite-sensitized persistent allergic rhinitis
Title: Association study on IL4, IL13 and IL4RA polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.
Data showed that polymorphisms in IL4, IL13, and their receptors do not play a role in SSc and do not influence the expression of their corresponding transcript in peripheral blood cells.
Title: Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.
The presented study suggested the possibility of a connection between the IL-13 gene polymorphism (-1112 C/T) and colorectal cancer risk in the Polish population.
Title: Association of -1112 c/t promoter region polymorphism of the interleukin 13 gene with occurrence of colorectal cancer.
all enveloped viruses, but none of the bacteria, blocked Th2 (IL-13) production by cord CD4(+) cells
Title: Enveloped virus but not bacteria block IL-13 responses in human cord blood T cells in vitro.
In Korean asthmatic children, increased serum IgE level was a multi-locus interaction between IL-4Ralpha, IL-13, IL-13Ralpha1, CD14, and CTLA4 polymorphisms. The combination of CTLA4/IL-13 and IL-13/IL-13Ralpha1 polymorphisms showed strong synergistic ...
Title: Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
GATA-binding protein 3 (Gata3) is essentially required for II13 gene expression in super T(h)1 cells.
Title: Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.
Chromatin Conformation Capture (3C) demonstrated the formation of specific ligation products containing spliced IL-4 and IL-13 DNA sequences in human T(H)2 polarised HuT-78 cells.
Title: Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping.
The role of the pro-fibrotic type 2 cytokine IL-13 and its regulation appear to be important in the pathogenesis of Systemic sclerosis.
Title: Role of IL-13 in systemic sclerosis.
the combination of rs3091307 GG/ rs2265753 GG (IL-13/IL-13Ralpha1) conveyed a significantly higher risk for developing atopic dermatitis
Title: Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.
the IL13 C-1112T and G+2044A polymorphisms predispose to asthma (Meta-Analysis)
Title: Association of interleukin-13 C-1112T and G+2044A polymorphisms with asthma: a meta-analysis.

Submit: New GeneRIF Correction See all (265)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A large-scale, consortium-based genomewide association study of asthma.

Allergic rhinitis, susceptibility to

MIM: 607154

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces IL-4 and IL-13 releases from human basophils through its interaction with the VH3 region of IgE	PubMed
	env	HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs	PubMed
Tat	tat	HIV-1 Tat induces IL-4 and IL-13 release from basophils, leading to dysregulation of the IgE/Fc epsilon RI network	PubMed
reverse transcriptase	gag-pol	IL-13 can act on macrophages both before and after HIV-1 infection to interfere with virus replication by blocking the completion of reverse transcription, decreasing virus production, and reducing the infectivity of the progeny virions	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs
P35225	P78552	IL13RA1	HPRD	PubMed
P35225	Q14627	IL13RA2	HPRD	PubMed
P35225	P24394	IL4R	HPRD	PubMed
P35225	P27986	PIK3R1	HPRD	PubMed
P35225	P19320	VCAM1	HPRD	PubMed

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
interleukin-13 receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell-cell signaling	IC Inferred by Curator more info	PubMed
cellular component movement	TAS Traceable Author Statement more info	PubMed
cellular response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
negative regulation of transforming growth factor beta production	IEA Inferred from Electronic Annotation more info
positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
positive regulation of ion transport	IEA Inferred from Electronic Annotation more info
positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of proton transport	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to nicotine	IEA Inferred from Electronic Annotation more info
signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
soluble fraction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: interleukin-13

Names: interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012090.1 RefSeqGene

Range

5001..7937

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002188.2 → NP_002179.2 interleukin-13 precursor

Status: REVIEWED

Source sequence(s)

X69079

Consensus CDS

CCDS4157.1

UniProtKB/Swiss-Prot

P35225

Related

ENSP00000304915, OTTHUMP00000066048, ENST00000304506, OTTHUMT00000132782

Conserved Domains (1) summary

cl11518
Location:20 – 145
Blast Score: 357

IL4; Interleukin 4

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

131993865..131996801

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

127186169..127189105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004039.1 (45620..48556)	None
genomic	AF172149.1	None
genomic	AF172150.1	None
genomic	AF193838.1	None
genomic	AF193839.1	None
genomic	AF193840.1	None
genomic	AF377331.2	AAK53823.1
genomic	AF416600.1	None
genomic	AY008331.1	None
genomic	AY008332.1	None
genomic	CH471062.2	EAW62324.1
		EAW62325.1
		EAW62326.1
		EAW62327.1
genomic	HI573912.1	CBX47445.1
genomic	L13029.1	None
genomic	L42079.1	None
genomic	L42080.1	None
genomic	U10307.1	AAA83738.1
genomic	U31120.1	AAB01681.1
mRNA	AF043334.1	AAC03535.1
mRNA	BC096138.3	AAH96138.1
mRNA	BC096139.1	AAH96139.1
mRNA	BC096140.3	AAH96140.1
mRNA	BC096141.1	AAH96141.2
mRNA	L06801.1	AAA36107.1
mRNA	X69079.1	CAA48823.1
		CAA48824.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P35225.2	GenPept	UniProtKB/Swiss-Prot:P35225
Q4VB50	GenPept	UniProtKB/TrEMBL:Q4VB50
Q4VB51	GenPept	UniProtKB/TrEMBL:Q4VB51
Q4VB53	GenPept	UniProtKB/TrEMBL:Q4VB53