Mad1 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Mad1provided by Flybase
Primary source: FLYBASE:FBgn0026326
Locus tag: Dmel_CG2072
Gene type: protein coding
RNA name: Mad1
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2072; Dmel\CG2072; TXBP181-like

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Genomic context

Location :: 45C4-45C4

Sequence :: Chromosome: 2R; NT_033778.3 (5176462..5179059, complement)

See Mad1 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:61790	BioGRID:62436	Arf51F	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:59234	CG12200	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:64303	CG32369	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:66994	CG5516	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:64700	CG7264	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:61730	CG8235	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:61727	CG8247	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:58239	Es2	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:68050	HLHmdelta	BioGRID	PubMed	Two-hybrid
BioGRID:61790	BioGRID:67158	ald	BioGRID	PubMed	Affinity Capture-MS
BioGRID:61790	BioGRID:64116	mad2	BioGRID	PubMed	Affinity Capture-MS

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General gene information

Homology

Homologs of the Mad1 gene: The Mad1 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, organism-specific biosystem (from REACTOME)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Amplification of signal from the kinetochores, organism-specific biosystem (from REACTOME)
Amplification of signal from the kinetochores, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
Mitotic Spindle Checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...

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General protein information

Preferred Names: CG2072 gene product from transcript CG2072-RA

Names: CG2072-PA; Mad1; Mad1-PA; TXBP181-like

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

5176462..5179059, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136633.3 → NP_610477.2 Mad1 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KND8

Related

FBpp0087680

Conserved Domains (1) summary

pfam05557
Location:15 – 726
Blast Score: 1572

MAD; Mitotic checkpoint protein