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hig hikaru genki [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35949, updated on 4-Apr-2024

Summary

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Official Symbol
higprovided by FlyBase
Official Full Name
hikaru genkiprovided by FlyBase
Primary source
FLYBASE:FBgn0010114
Locus tag
Dmel_CG2040
See related
AllianceGenome:FB:FBgn0010114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2040; CT6282; Dmel\CG2040; Hig; HIG
Summary
Involved in synaptic target recognition. Located in neuronal cell body and synaptic cleft. Is expressed in several structures, including central nervous system; extended germ band embryo; head; and ventral midline of embryo. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
45B7-45B8; 2-60 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9227785..9247249, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5115290..5134754, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45309 Neighboring gene long non-coding RNA:CR44451 Neighboring gene Cytochrome P450 4p2 Neighboring gene Cytochrome P450 4p1 Neighboring gene Cytochrome P450 4p3 Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene Protein kinase N Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neural expression of hikaru genki protein during embryonic and larval development of Drosophila melanogaster. Hoshino M, et al. Dev Genes Evol, 1999 Jan. PMID 9914413
  2. Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila. Hoshino M, et al. Development, 1996 Feb. PMID 8625810
  3. Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dα5 and Secreted Scaffold Protein Hig. Nakayama M, et al. J Neurosci, 2023 May 31. PMID 37117011, Free PMC Article
  4. hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein. Hoshino M, et al. Neuron, 1993 Mar. PMID 8461133
  5. Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. Sone M, et al. PLoS One, 2009. PMID 19209226, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dalpha5 and Secreted Scaffold Protein Hig.
    Title: Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dα5 and Secreted Scaffold Protein Hig.
  2. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts
    Title: The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis.
  3. Hig is a specific component of the synaptic cleft matrix of cholinergic synapses and regulates their postsynaptic organization.
    Title: The matrix protein Hikaru genki localizes to cholinergic synaptic clefts and regulates postsynaptic organization in the Drosophila brain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c9237124-9237044 mobile_element_type = transposon:INE-1{}3581

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hikaru genki
Names
CG2040-PA
CG2040-PB
CG2040-PC
CG2040-PD
hig-PA
hig-PB
hig-PC
hig-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9227785..9247249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165666.2 → NP_724772.1  hikaru genki, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R955
    Related
    FBpp0087687
    Conserved Domains (3) summary
    cd00033
    Location:807 → 866
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:680 → 927
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:869 → 927
    Sushi; Sushi repeat (SCR repeat)

  2. NM_080371.3 → NP_525110.2  hikaru genki, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525110.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R955
    Related
    FBpp0087689
    Conserved Domains (1) summary
    cd00033
    Location:807 → 866
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

  3. NM_165667.2 → NP_724773.1  hikaru genki, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724773.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09101, Q7KQU0, Q8IH50, Q9I7E3, Q9I7E4, Q9V560
    UniProtKB/TrEMBL
    E0R955
    Related
    FBpp0087688
    Conserved Domains (3) summary
    cd00033
    Location:832 → 891
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:705 → 952
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:894 → 952
    Sushi; Sushi repeat (SCR repeat)

  4. NM_001014514.2 → NP_001014514.1  hikaru genki, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014514.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R955
    Conserved Domains (1) summary
    cd00033
    Location:832 → 891
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09101.2 Q09101

Gene LinkOut

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