IL11RA interleukin 11 receptor, alpha [Homo sapiens (human)] - Gene

Summary

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Official Symbol: IL11RAprovided by HGNC
Official Full Name: interleukin 11 receptor, alphaprovided by HGNC
Primary source: HGNC:5967
Locus tag: hCG_2011440
See related: Ensembl:ENSG00000137070; HPRD:02965; MIM:600939; Vega:OTTHUMG00000019837
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRSDA
Summary: Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Genomic context

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Location :: 9p13

Sequence :: Chromosome: 9; NC_000009.11 (34652182..34661899)

See IL11RA in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Constructed a designer cytokine Hyper IL-11 (H11), which is exclusively composed of naturally existing components. It contains the full length sIL-11Ralpha connected with the mature IL-11 protein, and acts as an agonist on cells expressing the gp130 molec
Title: A designer hyper interleukin 11 (H11) is a biologically active cytokine.
IL11RA promoter polymorphism--rs1061758--may be associated with the risk of papillary thyroid cancer in the Korean population.
Title: Associations between promoter polymorphism -106A/G of interleukin-11 receptor alpha and papillary thyroid cancer in Korean population.
data suggest that IL-11Ralpha-CAR T cells may represent a new therapy for patients with osteosarcoma pulmonary metastases
Title: Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases.
IL11 as well as IL11RA are likely to play a role in the progression of endometrial carcinoma.
Title: Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
IL11 inhibits human extravillous trophoblast invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy.
Title: Interleukin 11 inhibits human trophoblast invasion indicating a likely role in the decidual restraint of trophoblast invasion during placentation.
binding site of il-11 to IL-11R alpha is characterized
Title: A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.
Observational study of gene-disease association. (HuGE Navigator)
Title: Risk of meningioma and common variation in genes related to innate immunity.
IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense
Title: Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro.

Submit: New GeneRIF Correction See all (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Craniosynostosis and dental anomalies

MIM: 614188

Genetic Testing Registry

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q14626	P20809	IL11		HPRD	PubMed

Pathways from BioSystems

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Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

General gene information

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Markers

STS-U32324 (e-PCR)
- UniSTS:50713

D9S1978 (e-PCR)
- UniSTS:77662

MARC_7064-7065:996687499:1 (e-PCR)
- UniSTS:269706

SHGC-35540 (e-PCR)
- UniSTS:47602

Genotypes

See IL11RA SNP Geneview Report
See IL11RA SNP Genotype Report
See IL11RA SNP Variation Viewer Report

Homology

Homologs of the IL11RA gene: The IL11RA gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cytokine receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	TAS Traceable Author Statement more info	PubMed
transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
developmental process	IMP Inferred from Mutant Phenotype more info
head development	IMP Inferred from Mutant Phenotype more info
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: interleukin-11 receptor subunit alpha

Names: interleukin-11 receptor subunit alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha; interleukin-11 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028966.1 RefSeqGene

Range

5001..14718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001142784.2 → NP_001136256.1 interleukin-11 receptor subunit alpha precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes a functional protein.

Source sequence(s)

BC003110, DA917660, Z38102

Consensus CDS

CCDS6567.1

UniProtKB/Swiss-Prot

Q14626

UniProtKB/TrEMBL

Q5VZ79

Related

ENSP00000394391, OTTHUMP00000244527, ENST00000441545, OTTHUMT00000410627

Conserved Domains (2) summary

cd00063
Location:218 – 309
Blast Score: 93

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

smart00410
Location:33 – 109
Blast Score: 108

IG_like; Immunoglobulin like

RNA

NR_052010.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC003110, DC424068, Z38102

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p10 Primary Assembly

Range

34652182..34661899

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

34606462..34616181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018920.1 Alternate CHM1_1.0

Range

34620668..34630385

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_004512.3: Suppressed sequence

Description

NM_004512.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_147162.1: Suppressed sequence

Description

NM_147162.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01065007.1 (6420..16139)	None
genomic	AL162231.20 (7714..17431)	None
genomic	AMYH01019340.1 (6317..16034)	None
genomic	AY532110.1	AAS00093.1
genomic	CH471071.2	EAW58422.1
		EAW58423.1
		EAW58424.1
		EAW58425.1
		EAW58426.1
genomic	U32323.1	AAB36491.1
genomic	Z46596.1	None
mRNA	AI377039.1	None
mRNA	AK075530.1	None
mRNA	AK094689.1	BAG52913.1
mRNA	AK292073.1	BAF84762.1
mRNA	BC003110.1	AAH03110.1
mRNA	BT009864.1	AAP88866.1
mRNA	DA917660.1	None
mRNA	DC424068.1	None
mRNA	U32324.1	AAB36492.1
mRNA	Z38102.1	CAA86224.1
mRNA	Z46595.1	CAA86570.1
other-genetic	DQ892342.2	ABM83268.1
other-genetic	DQ895548.2	ABM86474.1