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IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 3588, updated on 12-May-2016
Official Symbol
IL10RBprovided by HGNC
Official Full Name
interleukin 10 receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:5965
See related
Ensembl:ENSG00000243646 HPRD:00473; MIM:123889; Vega:OTTHUMG00000065128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
Summary
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Orthologs
Location:
21q22.11
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (33266360..33297234)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638665..34669539)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene IL10RB antisense RNA 1 (head to head) Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene interferon gamma receptor 2 (interferon gamma transducer 1) Neighboring gene transmembrane protein 50B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hepatitis b virus, susceptibility to
MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
Compare labs
Inflammatory bowel disease 25, autosomal recessive
MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
    Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Type III interferon signaling, organism-specific biosystem (from WikiPathways)
    Type III interferon signaling, organism-specific biosystemThe recently identified type III interferon group consists of three IFN-? (lambda) genes encoding molecules called IFN-?1, IFN-?2 and IFN-?3 (also called IL29, IL28A and IL28B respectively). These IF...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: IFNAR2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to interleukin-10 receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
interleukin-28 receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
interleukin-10 receptor subunit beta
Names
IL-10 receptor subunit beta
IL-10R subunit 2
IL-10R subunit beta
IL-10RB
cytokine receptor class-II CRF2-4
cytokine receptor class-II member 4
cytokine receptor family 2 member 4
cytokine receptor family II, member 4
interleukin 10 receptor, beta
interleukin-10 receptor subunit 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012089.1 RefSeqGene

    Range
    4994..35868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

mRNA and Protein(s)

  1. NM_000628.4NP_000619.3  interleukin-10 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_000619.3

    Status: REVIEWED

    Source sequence(s)
    AI025402, AU133530, BC001903, Z17227
    Consensus CDS
    CCDS13623.1
    UniProtKB/Swiss-Prot
    Q08334
    Related
    ENSP00000290200, OTTHUMP00000067678, ENST00000290200, OTTHUMT00000139831
    Conserved Domains (2) summary
    pfam01108
    Location:7100
    Tissue_fac; Tissue factor
    cd00063
    Location:154212
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    33266360..33297234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    34201309..34232176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)