IL9 interleukin 9 [Homo sapiens] - Gene

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Summary

Official Symbol: IL9provided by HGNC
Official Full Name: interleukin 9provided by HGNC
Primary source: HGNC:6029
See related: Ensembl:ENSG00000145839; HPRD:00910; MIM:146931; Vega:OTTHUMG00000129147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P40; HP40; IL-9
Summary: The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q31.1

Sequence :: Chromosome: 5; NC_000005.9 (135227935..135231516, complement)

See IL9 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma
Title: IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.
Serum IL-9 level was increased in patients with systemic sclerosis, and was associated with lower frequency and severity of pulmonary fibrosis in systemic sclerosis.
Title: Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis.
IL-33 can initiate IL-9 protein secretion in vitro in human CD4+ T cells and basophils.
Title: IL-33 induces IL-9 production in human CD4+ T cells and basophils.
TAK1-c-Rel and IRF4 pathways play distinct roles in the maintenance of IL-9-producing Th17 phenotype of HTLV-1-transformed cells
Title: Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.
The increase of plasma IL-9, and the decrease of plasma IL-5, IL-7 and IFN-gamma may contribute to get further insights into the inflammatory pathways involved in chronic heart failure.
Title: Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-γ in patients with chronic heart failure.
analysis of IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population
Title: An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population.
results demonstrate a previously unappreciated role for IL-9 in dampening the pathogenic activities of Th17 cells
Title: IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease.
The interaction of 6-locus from the 5 interleukin genes might confer higher risk for graves'disease and Graves'ophthalmopathy than single risk allele.
Title: Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease.
Serum IL-9 levels may depend on allergen exposure: symptomatic patients with pollen-induced allergic rhinitis (AR), evaluated during the pollen season, have higher values than patients studied outside the pollen season and without symptoms.
Title: Serum IL-9 levels depend on allergen exposure: preliminary study.
the IL-9 genetic polymorphism (rs2069885) has an opposite effect on the risk of severe respiratory syncytial virus bronchiolitis in boys and girls.
Title: Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.

Submit: New GeneRIF Correction See all (43)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NC_000005.8	NP_003143.2	STAT5A		BIND	PubMed	STAT5A interacts with IL-9 promoter.
P15248	Q01113	IL9R		HPRD	PubMed

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info
interleukin-9 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-5 biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: interleukin-9

Names: interleukin-9; cytokine P40; p40 cytokine; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000590.1 → NP_000581.1 interleukin-9 precursor

Status: REVIEWED

Source sequence(s)

S63356

Consensus CDS

CCDS4189.1

UniProtKB/Swiss-Prot

P15248

Related

ENSP00000274520, OTTHUMP00000159423, ENST00000274520, OTTHUMT00000251210

Conserved Domains (1) summary

cl11602
Location:15 – 142
Blast Score: 415

IL7; Interleukin 7/9 family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

135227935..135231516, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

130416404..130419991, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC002428.1	AAB66904.1
genomic	AC004763.1	AAC17735.1
genomic	AF361105.1	AAK26666.1
genomic	CH471062.2	EAW62204.1
genomic	M30135.1	AAA35887.1
genomic	M86593.1	AAA59161.1
mRNA	BC066283.1	AAH66283.1
mRNA	BC066284.1	AAH66284.1
mRNA	BC066285.1	AAH66285.1
mRNA	BC066286.1	AAH66286.1
mRNA	BC066287.1	AAH66287.1
mRNA	M30134.1	AAA36400.1
mRNA	S63356.1	AAB19823.1
mRNA	X17543.1	CAA35581.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P15248.1	GenPept	UniProtKB/Swiss-Prot:P15248
Q6NZ74	GenPept	UniProtKB/TrEMBL:Q6NZ74
Q6NZ75	GenPept	UniProtKB/TrEMBL:Q6NZ75