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IL9 interleukin 9 [ Homo sapiens (human) ]

Gene ID: 3578, updated on 8-May-2016
Official Symbol
IL9provided by HGNC
Official Full Name
interleukin 9provided by HGNC
Primary source
HGNC:HGNC:6029
See related
Ensembl:ENSG00000145839 HPRD:00910; MIM:146931; Vega:OTTHUMG00000129147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P40; HP40; IL-9
Summary
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (135892246..135895827, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135227935..135231516, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 5692c-1 Neighboring gene solute carrier family 25 member 48 Neighboring gene F-box and leucine-rich repeat protein 21 (gene/pseudogene) Neighboring gene leukocyte cell derived chemotaxin 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Asthma, organism-specific biosystem (from KEGG)
    Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
  • Asthma, conserved biosystem (from KEGG)
    Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-9 Signaling Pathway, organism-specific biosystemInterleukin-9 belongs to a family of cytokines, which includes IL-2, IL-4, IL-7, IL-15 and IL-21. It signals through a receptor complex consisting of an IL-9 receptor (IL9R) and a common gamma chain ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-9 receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interleukin-5 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-9
Names
T-cell growth factor p40
cytokine P40
homolog of mouse T cell and mast cell growth factor 40
p40 T-cell and mast cell growth factor
p40 cytokine

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000590.1NP_000581.1  interleukin-9 precursor

    See identical proteins and their annotated locations for NP_000581.1

    Status: REVIEWED

    Source sequence(s)
    S63356
    Consensus CDS
    CCDS4189.1
    UniProtKB/Swiss-Prot
    P15248
    Related
    ENSP00000274520, OTTHUMP00000159423, ENST00000274520, OTTHUMT00000251210
    Conserved Domains (1) summary
    pfam01415
    Location:15142
    IL7; Interleukin 7/9 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    135892246..135895827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    134660566..134664147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)