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    IL7R interleukin 7 receptor [ Homo sapiens (human) ]

    Gene ID: 3575, updated on 19-May-2013
    Official Symbol
    IL7Rprovided by HGNC
    Official Full Name
    interleukin 7 receptorprovided by HGNC
    Primary source
    HGNC:6024
    See related
    Ensembl:ENSG00000168685; HPRD:00893; MIM:146661; Vega:OTTHUMG00000090791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILRA; CD127; IL7RA; CDW127; IL-7R-alpha
    Summary
    The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008]
    Location :
    5p13
    Sequence :
    Chromosome: 5; NC_000005.9 (35856977..35879705)
    See IL7R in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene prolactin receptor Neighboring gene sperm flagellar 2 Neighboring gene uncharacterized LOC100506406 Neighboring gene calcyphosine-like

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Tat, p14 tat HIV-1 Tat-mediated degradation of IL-7R alpha-chain (CD127) from the surface of resting CD8 T cells leads to reduced IL-7 signaling and to impaired CD8 T cell proliferation and function PubMed
    tat HIV-1 Tat and IL-7 act synergistically to downregulate CD127 on CD8+ T cells. Downregulation of CD127 by IL-7 requires JAK activation pathway PubMed
    tat HIV-1 Tat upregulates the expression of IL-7R in human macrophages, which leads to the enhancement of HIV-1 replication PubMed
    tat HIV-1 Tat inhibits the effects of IL-7 on activation of CD8 T-cells signaling via IL-7R PubMed
    tat HIV-1 Tat downregulates cell surface expression of IL-7R on human CD8 T-cells in a dose- and time-dependent manner PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002176.2 NP_000871.1 IL7    BIND  PubMed IL7 interacts with IL-7R-alpha. 
    P16871 Q9HC73 CRLF2    HPRD  PubMed  
    P16871 P06241 FYN    HPRD  PubMed  
    P16871 P31785 IL2RG    HPRD  PubMed  
    P16871 P13232 IL7    HPRD  PubMed  
    P16871 P23458 JAK1    HPRD  PubMed  
    P16871 P52333 JAK3    HPRD  PubMed  
    P16871 P07948 LYN    HPRD  PubMed  
    P16871 P27986 PIK3R1    HPRD  PubMed  
    P16871 Q14289 PTK2B    HPRD  PubMed  
    P16871 P40763 STAT3    HPRD  PubMed  
    P16871 P42229 STAT5A    HPRD  PubMed  
    P16871 P51692 STAT5B    HPRD  PubMed  
    P16871 Thymic stromal lymphopoietin TSLP    HPRD  PubMed  
    BioGRID:109789 BioGRID:115486 ALYREF    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109789 BioGRID:107573 CIRBP    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:118946 CPSF1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:114625 DDX21    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113649 DDX39B    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108020 DDX3X    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108021 DDX5    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:128022 DHX36    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108025 DHX9    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:111596 EIF2AK2    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108309 ELAVL1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115703 EMG1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108491 FAU    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108797 FUS    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108810 FYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109789 BioGRID:115448 G3BP1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115671 GNB2L1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:114461 H1FX    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109261 HIST1H1C    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109263 HIST1H1E    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:116149 HNRNPA0    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:128670 HNRNPA3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109423 HNRNPAB    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109424 HNRNPC    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109425 HNRNPD    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109430 HNRNPH3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109432 HNRNPL    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115530 HNRNPR    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109433 HNRNPU    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:116281 HNRNPUL1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:128685 HNRNPUL2    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115308 HNRPDL    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109821 ILF2    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:109822 ILF3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:110306 MAP4    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:110771 NCL    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:110904 NONO    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:117939 PABPC1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:114296 PABPC4    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113777 PABPN1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:111697 PTBP1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:108480 PTK2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109789 BioGRID:111724 PTMA    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:111772 PURA    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:111773 PURB    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:114834 QKI    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:111822 RAD21    BioGRID  PubMed Two-hybrid 
    BioGRID:109789 BioGRID:111870 RBM3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:118134 RBMX    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112058 RPL15    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112061 RPL18    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112066 RPL22    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112078 RPL29    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112075 RPL30    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112079 RPL31    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112048 RPL6    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112049 RPL7    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112052 RPL8    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112138 RPS20    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112102 RPS3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:110115 RPSA    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115912 RRAGA    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:117587 RSL1D1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112201 SAFB    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113368 SF1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115580 SF3A1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:117017 SF3B1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112509 SNRNP70    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112510 SNRPA    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112512 SNRPB    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112516 SNRPD1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112517 SNRPD2    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112518 SNRPD3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112519 SNRPE    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112520 SNRPF    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112521 SNRPG    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112605 SRP14    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112604 SRP9    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112326 SRSF3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:114231 SRSF9    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:112619 SSB    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:115755 SYNCRIP    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:125269 TOE1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113003 TOP1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113157 U2AF1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:116466 U2AF2    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109789 BioGRID:110959 YBX1    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:114101 YBX3    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113363 YWHAE    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:113364 YWHAG    BioGRID  PubMed Protein-RNA 
    BioGRID:109789 BioGRID:125966 ZNF787    BioGRID  PubMed Protein-RNA 
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-7 signaling, organism-specific biosystemInterleukin-7 (IL7) is produced primarily by T zone fibroblastic reticular cells found in lymphoid organs, and also expressed by non-hematopoietic stromal cells present in other tissues including the...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • TSLP Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TSLP Signaling Pathway, organism-specific biosystemThymic stromal lymphopoietin (TSLP) is a type I cytokine member of interleukin-2 cytokine family. TSLP signals through interleukin-7 receptor a chain (IL-7Ra) and the TSLP receptor subunit (TSLPR), h...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-7 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-7-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    lymph node development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    interleukin-7 receptor subunit alpha
    Names
    interleukin-7 receptor subunit alpha
    IL-7RA
    CD127 antigen
    IL-7R subunit alpha
    IL-7 receptor subunit alpha
    interleukin 7 receptor alpha chain
    interleukin 7 receptor isoform H5-6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009567.1 RefSeqGene

      Range
      4987..26934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_74

    mRNA and Protein(s)

    1. NM_002185.3NP_002176.2  interleukin-7 receptor subunit alpha precursor

      Status: REVIEWED

      Source sequence(s)
      AC112204, AF373204, BC020717, BC067540, CD703890
      Consensus CDS
      CCDS3911.1
      UniProtKB/Swiss-Prot
      P16871
      Related
      ENSP00000306157, OTTHUMP00000116000, ENST00000303115, OTTHUMT00000207577
      Conserved Domains (1) summary
      pfam00041
      Location:131218
      Blast Score: 121
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      35856977..35879705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      35806996..35829599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      35800799..35823528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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