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    sax saxophone [ Drosophila melanogaster ]

    Gene ID: 35731, updated on 10-May-2012

    Summary

    Official Symbol
    saxprovided by Flybase
    Official Full Name
    saxophoneprovided by Flybase
    Primary source
    FLYBASE:FBgn0003317
    Locus tag
    Dmel_CG1891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bkr43E; Brk43E; CG1891; Dmel\CG1891; Sa; Sax; SAX; STK-B

    Genomic context

    Location :
    43E18-43E18; 2-57 cM
    Sequence :
    Chromosome: 2R; NT_033778.3 (3693983..3697572)

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 1 Neighboring gene mutagen-sensitive 205 Neighboring gene CG1553 gene product from transcript CG1553-RA Neighboring gene CG1550 gene product from transcript CG1550-RA Neighboring gene CG1882 gene product from transcript CG1882-RA

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61598 BioGRID:63722 CG12004    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:72605 CG14767    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:59432 CG3164    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:64899 CG32138    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:68088 CG5447    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:65457 CG7668    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:60939 CycE    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:67421 H    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:59745 Mad    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:68568 Med    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:67007 Mhcl    BioGRID  PubMed Two-hybrid 
    BioGRID:61598 BioGRID:60256 Pvr    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:61901 Syb    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:68116 Tl    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:63903 ZnT63C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:59659 dpp    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:63372 gbb    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:68673 nej    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:70052 scw    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:66694 snk    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:69637 spin    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61598 BioGRID:69994 spir    BioGRID  PubMed Two-hybrid 
    BioGRID:61598 BioGRID:63919 sty    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61598 BioGRID:59924 tkv    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression 

    General gene information

    Homology

    • Homologs of the sax gene: The sax gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
     
    transforming growth factor beta receptor activity, type I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transforming growth factor beta receptor activity, type I ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transforming growth factor beta receptor activity, type I NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chorion-containing eggshell formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    compound eye morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    decapentaplegic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    decapentaplegic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-line stem cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal determination of anterior/posterior axis, embryo IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    maternal determination of anterior/posterior axis, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    ovarian nurse cell to oocyte transport TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    wing disc pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    CG1891 gene product from transcript CG1891-RC
    Names
    CG1891-PA
    CG1891-PB
    CG1891-PC
    sax-PA
    sax-PB
    sax-PC
    saxophone
    NP_001246193.1
    NP_523652.2
    NP_724606.1

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      3693983..3697572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259264.1NP_001246193.1  saxophone, isoform C [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_078928.3NP_523652.2  saxophone, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQ36
      Related
      FBpp0087908
      Conserved Domains (5) summary
      cd00180
      Location:270469
      Blast Score: 374
      PKc; Catalytic domain of Protein Kinases
      pfam01064
      Location:65156
      Blast Score: 113
      Activin_recp; Activin types I and II receptor domain
      cl02621
      Location:234262
      Blast Score: 131
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
      pfam00069
      Location:265549
      Blast Score: 468
      Pkinase; Protein kinase domain
      cl09925
      Location:390553
      Blast Score: 135
      PKc_like; Protein Kinases, catalytic domain
    3. NM_165559.2NP_724606.1  saxophone, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U21
      Related
      FBpp0087909
      Conserved Domains (5) summary
      cd00180
      Location:235434
      Blast Score: 378
      PKc; Catalytic domain of Protein Kinases
      pfam01064
      Location:30121
      Blast Score: 111
      Activin_recp; Activin types I and II receptor domain
      cl02621
      Location:199227
      Blast Score: 130
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
      pfam00069
      Location:230514
      Blast Score: 471
      Pkinase; Protein kinase domain
      cl09925
      Location:355518
      Blast Score: 135
      PKc_like; Protein Kinases, catalytic domain

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AFH07948.1
    genomic AE013599.4 AAF59189.1
    mRNA L33790.1 AAA61946.1
    mRNA AY058363.1 AAL13592.1
    genomic AE013599.4 AAM68863.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27931.1 GenPept

      Supplemental Content