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    didum dilute class unconventional myosin [ Drosophila melanogaster ]

    Gene ID: 35680, updated on 10-May-2012
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    Summary

    Official Symbol
    didumprovided by Flybase
    Official Full Name
    dilute class unconventional myosinprovided by Flybase
    Primary source
    FLYBASE:FBgn0261397
    Locus tag
    Dmel_CG2146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    43CD; CG2146; Didum; Dmel\CG2146; DmV; M5; myoV; MyoV; MYOV; MyoV43CD; NEST:bs14c05; NMC7; soy
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    Genomic context

    Location :
    43C7-43D1
    Sequence :
    Chromosome: 2R; NT_033778.3 (3387660..3396130)
    See didum in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG1620 gene product from transcript CG1620-RA Neighboring gene disc proliferation abnormal Neighboring gene CG12736 gene product from transcript CG12736-RA Neighboring gene CG1605 gene product from transcript CG1605-RA Neighboring gene CG1603 gene product from transcript CG1603-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. Finan D, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21368190.
    3. Defects in mitochondrial axonal transport and membrane potential without increased reactive oxygen species production in a Drosophila model of Friedreich ataxia. Shidara Y, et al. J Neurosci, 2010 Aug 25. PMID 20739558.
    4. Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria. Pathak D, et al. J Neurosci, 2010 Jun 30. PMID 20592219.
    5. Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia. Serio AW, et al. Cell Host Microbe, 2010 May 20. PMID 20478540.

    See all (44) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. data indicate that myosin V and VI, but not II, play related but distinct roles in regulating microtubule (MT)-based mitochondrial movement: they oppose, rather than complement, protracted MT-based movements and perhaps facilitate organelle docking
      Title: Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria.
    2. the mechanical properties of coiled-coil regions of myosin v
      Title: Extensibility of the extended tail domain of processive and nonprocessive myosin V molecules.
    3. Data show that didum, encoding the Drosophila actin-based motor Myosin-V, is a new posterior group gene that promotes posterior accumulation of Oskar.
      Title: Myosin-V regulates oskar mRNA localization in the Drosophila oocyte.
    4. MyoV was associated with membranes, microtubule, and actin structures required for spermatid maturation.
      Title: Drosophila myosin V is required for larval development and spermatid individualization.
    5. Myosin V delivers morphogenic secretory traffic along polarized actin filaments of the subcortical terminal web to the exocytic plasma membrane target, the rhabdomere base.
      Title: Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.
    6. analysis of the motor mechanism of Drosophila Myosin V
      Title: Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61556 BioGRID:63011 Act57B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:69379 And    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:61277 Arc-p34    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:58961 Arp14D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:61149 CG10641    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:58721 CG11092    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:66688 CG11656    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:68115 CG14247    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:72528 CG14545    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:66837 CG14850    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:72659 CG17776    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:59807 CG31958    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:64754 CG32100    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:66936 CG34404    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:66866 CG3610    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:59164 CG6617    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:64885 CG9040    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:57980 Mlc-c    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:61650 Mlh1    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:64238 Neos    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:69006 Rab-RP4    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:60239 Rbsn-5    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:62820 SP2637    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:67060 Scp2    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:61048 Sgt    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:59993 Vm26Ac    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:63026 cpa    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:59586 cpb    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61556 BioGRID:57878 dgt4    BioGRID  PubMed Two-hybrid 
    BioGRID:61556 BioGRID:63286 yip3    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the didum gene: The didum gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, and A.thaliana.

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    ATPase activity, coupled ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    actin-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    myosin light chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitochondrion transport along microtubule IDA
    Inferred from Direct Assay
    more info
    		  
    NOT oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    myosin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG2146 gene product from transcript CG2146-RC
    Names
    CG2146-PA
    CG2146-PB
    CG2146-PC
    MyosinV
    didum-PA
    didum-PB
    didum-PC
    dilute class unconventional myosin
    myosin V
    myosin-V
    shorty
    NP_477186.1
    NP_724569.1
    NP_724570.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      3387660..3396130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165535.1 → NP_724569.1  dilute class unconventional myosin, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Z8
      Related
      FBpp0088684, FBtr0089743
      Conserved Domains (5) summary
      cd01380
      Location:71 – 778
      Blast Score: 2764
      MYSc_type_V; Myosin motor domain, type V myosins. Myosins V transport a variety of intracellular cargo processively along actin filaments, such as membraneous organelles and mRNA. This catalytic (head) domain has ATPase activity and belongs to the larger group of ...
      TIGR02168
      Location:1036 – 1365
      Blast Score: 158
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      smart00242
      Location:65 – 778
      Blast Score: 2444
      MYSc; Myosin. Large ATPases.
      pfam01843
      Location:1630 – 1733
      Blast Score: 351
      DIL; DIL domain
      cl15479
      Location:900 – 922
      Blast Score: 89
      IQ; IQ calmodulin-binding motif

    2. NM_057838.3 → NP_477186.1  dilute class unconventional myosin, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Z9
      Related
      FBpp0088686, FBtr0089745
      Conserved Domains (5) summary
      cd01380
      Location:71 – 770
      Blast Score: 2764
      MYSc_type_V; Myosin motor domain, type V myosins. Myosins V transport a variety of intracellular cargo processively along actin filaments, such as membraneous organelles and mRNA. This catalytic (head) domain has ATPase activity and belongs to the larger group of ...
      TIGR02168
      Location:1028 – 1357
      Blast Score: 158
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      smart00242
      Location:65 – 770
      Blast Score: 2452
      MYSc; Myosin. Large ATPases.
      pfam01843
      Location:1622 – 1725
      Blast Score: 351
      DIL; DIL domain
      cl15479
      Location:892 – 914
      Blast Score: 89
      IQ; IQ calmodulin-binding motif

    3. NM_165536.2 → NP_724570.1  dilute class unconventional myosin, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z700
      Related
      FBpp0088685, FBtr0089744
      Conserved Domains (3) summary
      cd01380
      Location:71 – 770
      Blast Score: 2773
      MYSc_type_V; Myosin motor domain, type V myosins. Myosins V transport a variety of intracellular cargo processively along actin filaments, such as membraneous organelles and mRNA. This catalytic (head) domain has ATPase activity and belongs to the larger group of ...
      smart00242
      Location:65 – 770
      Blast Score: 2463
      MYSc; Myosin. Large ATPases.
      cl15479
      Location:892 – 914
      Blast Score: 87
      IQ; IQ calmodulin-binding motif
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAM68902.1
    genomic AE013599.4 AAF59241.2
    genomic AE013599.4 AAM68903.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MKM1.1 GenPept
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    Additional Links

    Gene LinkOut

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