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    pgant3 polypeptide GalNAc transferase 3 [ Drosophila melanogaster ]

    Gene ID: 35627, updated on 10-May-2012
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    Summary

    Official Symbol
    pgant3provided by Flybase
    Official Full Name
    polypeptide GalNAc transferase 3provided by Flybase
    Primary source
    FLYBASE:FBgn0027558
    Locus tag
    Dmel_CG4445
    Gene type
    protein coding
    RNA name
    polypeptide GalNAc transferase 3
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.119; BcDNA:GH09147; CG4445; Dmel\CG4445
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    Genomic context

    Location :
    42E7-42E7
    Sequence :
    Chromosome: 2R; NT_033778.3 (2945156..2949224, complement)
    See pgant3 in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42En Neighboring gene Tetraspanin 42Eo Neighboring gene Tetraspanin 42Ep Neighboring gene Tetraspanin 42Eq Neighboring gene Tetraspanin 42Er

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760.
    2. An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. Zhang L, et al. J Biol Chem, 2010 Jun 18. PMID 20371600.
    3. A mucin-type O-glycosyltransferase modulates cell adhesion during Drosophila development. Zhang L, et al. J Biol Chem, 2008 Dec 5. PMID 18835818.
    4. Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. Haussmann IU, et al. Genome Biol, 2008 Apr 17. PMID 18419806.
    5. Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. Liu Y, et al. Insect Mol Biol, 2008 Apr. PMID 18353099.

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the glycosyltransferase, pgant3, specifically modulates integrin-mediated cell adhesion by influencing the secretion and localization of the integrin ligand, Tiggrin
      Title: An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61516 BioGRID:59544 CG4577    BioGRID  PubMed Two-hybrid 
    BioGRID:61516 BioGRID:66990 CG5478    BioGRID  PubMed Two-hybrid 
    BioGRID:61516 BioGRID:65440 CG7757    BioGRID  PubMed Two-hybrid 
    BioGRID:61516 BioGRID:71867 Src64B    BioGRID  PubMed Two-hybrid 
    BioGRID:61516 BioGRID:61489 koi    BioGRID  PubMed Two-hybrid 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    polypeptide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    transferase activity, transferring glycosyl groups IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    O-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		  
    extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		  
    oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG4445 gene product from transcript CG4445-RA
    Names
    CG4445-PA
    pgant3-PA
    polypeptide GalNAc transferase 3
    NP_610256.1
    • unusual splice
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      2945156..2949224, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136412.2 → NP_610256.1  polypeptide GalNAc transferase 3 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y117
      Related
      FBpp0088130, FBtr0089061
      Conserved Domains (4) summary
      cd00161
      Location:524 – 660
      Blast Score: 136
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      cd02510
      Location:153 – 457
      Blast Score: 1164
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans.
      pfam00652
      Location:524 – 658
      Blast Score: 157
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:150 – 386
      Blast Score: 98
      Glyco_tranf_2_3; Glycosyltransferase like family 2
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AF145655.1 AAD38630.1
    genomic AE013599.4 AAF59298.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y117.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content