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    Epac [ Drosophila melanogaster ]

    Gene ID: 35588, updated on 10-May-2012

    Summary

    Official Symbol
    Epacprovided by Flybase
    Primary source
    FLYBASE:FBgn0085421
    Locus tag
    Dmel_CG34392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15235; CG3427; CG34392; D-Epac; D-EPAC; Dmel\CG34392; epac

    Genomic context

    Location :
    42D1-42D1
    Sequence :
    Chromosome: 2R; NT_033778.3 (2649417..2684421, complement)
    See Epac in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG3420 gene product from transcript CG3420-RA Neighboring gene CG9436 gene product from transcript CG9436-RA Neighboring gene Cytochrome P450-6a2 Neighboring gene CG15237 gene product from transcript CG15237-RA Neighboring gene Succinate dehydrogenase B Neighboring gene ubiquitin like

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61484 BioGRID:66948 CG14869    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:63952 CG14983    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:72590 CG16836    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:61210 CG18094    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:72838 CG32164    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:72839 CG32165    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:63257 CG3831    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:1073014 CG42542    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:60285 CG42820    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:59533 CG4415    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:65127 CG4729    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:67807 CG5515    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:66957 CG6045    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:60193 CG7211    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:64598 CG7949    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:58866 CG8206    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:72636 CG8620    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:62961 CG8929    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:58935 Cyp1    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:62406 Cyp6a20    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:67048 Dhfr    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:64472 Hsp23    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68299 Pkc98E    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68762 Pten    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:63429 Rap2l    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68014 RpL27    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68450 RpS7    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:64500 RpS9    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68095 TwdlM    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:63944 Ubi-p63E    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:67688 cnc    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:64386 foi    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68425 janA    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:67624 loco    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:68604 plexB    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:62852 sano    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:59109 scu    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:60966 twe    BioGRID  PubMed Two-hybrid 
    BioGRID:61484 BioGRID:60116 wee    BioGRID  PubMed Two-hybrid 

    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    Rap guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cAMP-dependent protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cAMP-dependent protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CG34392 gene product from transcript CG34392-RC
    Names
    CG34392-PC
    CG34392-PD
    Epac-PC
    Epac-PD
    epac
    epac guanine nucleotide exchange factor
    NP_001097202.1
    • unusual splice
    NP_724498.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      2649417..2684421, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103732.1NP_001097202.1  epac, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6P8
      Related
      FBpp0111547, FBtr0112635
      Conserved Domains (5) summary
      cd00038
      Location:345455
      Blast Score: 196
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:758991
      Blast Score: 544
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd04437
      Location:191322
      Blast Score: 443
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      cd06224
      Location:486607
      Blast Score: 146
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl00155
      Location:655714
      Blast Score: 88
      UBQ; Ubiquitin-like proteins
    2. NM_165490.1NP_724498.1  epac, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z6
      Related
      FBpp0111548, FBtr0112636
      Conserved Domains (5) summary
      cd00038
      Location:208318
      Blast Score: 198
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:621854
      Blast Score: 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd04437
      Location:54185
      Blast Score: 446
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      cd06224
      Location:349470
      Blast Score: 146
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl00155
      Location:507577
      Blast Score: 89
      UBQ; Ubiquitin-like proteins

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF57395.2
    mRNA AY058255.1 AAL13484.1
    genomic AE013599.4 AAM70831.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9A3.1 GenPept

      Supplemental Content