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PGAP3 Post-GPI attachment to proteins 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35570, updated on 11-Apr-2024

Summary

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Official Symbol
PGAP3provided by FlyBase
Official Full Name
Post-GPI attachment to proteins 3provided by FlyBase
Primary source
FLYBASE:FBgn0033088
Locus tag
Dmel_CG3271
See related
AllianceGenome:FB:FBgn0033088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3271; Dmel\CG3271
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be intrinsic component of endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
42C4-42C4; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6673604..6675061)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2561109..2562566)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate C5-epimerase Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene Tyrosine decarboxylase 1 Neighboring gene long non-coding RNA:CR44164

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid. Dejima K, et al. J Biol Chem, 2013 Nov 29. PMID 24133213, Free PMC Article
  2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on ester bonds ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Post-GPI attachment to proteins 3
Names
CG3271-PA
CG3271-PB
PGAP3-PA
PGAP3-PB
Post-GPI attachment to proteins 3 ortholog
NP_610223.1
NP_724485.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6673604..6675061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165482.4 → NP_724485.1  Post-GPI attachment to proteins 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724485.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6N0, Q7K0P4
    Related
    FBpp0085452
    Conserved Domains (1) summary
    pfam04080
    Location:65 → 306
    Per1; Per1-like

  2. NM_136379.4 → NP_610223.1  Post-GPI attachment to proteins 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610223.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K0P4
    Related
    FBpp0085453
    Conserved Domains (1) summary
    pfam04080
    Location:65 → 313
    Per1; Per1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0P4.2 Q7K0P4

Gene LinkOut

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