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IL1RAP interleukin 1 receptor accessory protein [ Homo sapiens (human) ]

Gene ID: 3556, updated on 26-May-2016
Official Symbol
IL1RAPprovided by HGNC
Official Full Name
interleukin 1 receptor accessory proteinprovided by HGNC
Primary source
HGNC:HGNC:5995
See related
Ensembl:ENSG00000196083 HPRD:04021; MIM:602626; Vega:OTTHUMG00000156211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL1R3; C3orf13; IL-1RAcP
Summary
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Orthologs
Location:
3q28
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (190514051..190657197)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190231840..190378856)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene claudin 16 Neighboring gene transmembrane protein 207 Neighboring gene glucosaminyl (N-acetyl) transferase 1, core 2 pseudogene 3 Neighboring gene uncharacterized LOC105374272 Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
NHGRI GWA Catalog
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
protein complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-1 receptor accessory protein
Names
IL-1 receptor accessory protein
IL-1R3
interleukin-1 receptor 3
interleukin-1 receptor accessory protein beta

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029105.1 RefSeqGene

    Range
    5001..148147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167928.1NP_001161400.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes the membrane-bound isoform (1).
    Source sequence(s)
    AB006537, AK291669, BG032519, BM194193, BM760155, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    UniProtKB/TrEMBL
    A8K6K4
    Related
    ENSP00000401132, OTTHUMP00000209486, ENST00000439062, OTTHUMT00000343498
    Conserved Domains (3) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:408545
    TIR; TIR domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  2. NM_001167929.1NP_001161401.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161401.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes the membrane-bound isoform (1).
    Source sequence(s)
    AF538733, BM194193, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000072516, OTTHUMP00000209485, ENST00000072516, OTTHUMT00000343497
    Conserved Domains (3) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:408545
    TIR; TIR domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  3. NM_001167930.1NP_001161402.1  interleukin-1 receptor accessory protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. It encodes the soluble isoform (2).
    Source sequence(s)
    AC008249, AF538732, DA024801
    Consensus CDS
    CCDS46982.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000387371, OTTHUMP00000209492, ENST00000422940, OTTHUMT00000343504
    Conserved Domains (2) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  4. NM_001167931.1NP_001161403.1  interleukin-1 receptor accessory protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001161403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    DA024801, DN990628, EF591790
    Consensus CDS
    CCDS54696.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000314807, OTTHUMP00000209490, ENST00000317757, OTTHUMT00000343502
    Conserved Domains (3) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    smart00255
    Location:404547
    TIR; Toll - interleukin 1 - resistance
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  5. NM_002182.3NP_002173.1  interleukin-1 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_002173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the membrane-bound isoform (1).
    Source sequence(s)
    AB006537, BM194193, BM973472, DA024801
    Consensus CDS
    CCDS3298.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000390541, OTTHUMP00000209489, ENST00000447382, OTTHUMT00000343501
    Conserved Domains (3) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:408545
    TIR; TIR domain
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  6. NM_134470.3NP_608273.1  interleukin-1 receptor accessory protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_608273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' end of the coding region and 3' UTR, compared to variant 1. It encodes the soluble isoform (2).
    Source sequence(s)
    AC008249, AF538734, BC053621, DA024801
    Consensus CDS
    CCDS46982.1
    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000409352, OTTHUMP00000209487, ENST00000422485, OTTHUMT00000343499
    Conserved Domains (2) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    cl11960
    Location:26131
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    190514051..190657197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247433.2XP_005247490.1  

    See identical proteins and their annotated locations for XP_005247490.1

    UniProtKB/Swiss-Prot
    Q9NPH3
    Related
    ENSP00000408893, ENST00000443369
    Conserved Domains (3) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    smart00255
    Location:404547
    TIR; Toll - interleukin 1 - resistance
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  2. XM_011512794.1XP_011511096.1  

    Conserved Domains (3) summary
    PHA02785
    Location:8334
    PHA02785; IL-beta-binding protein; Provisional
    smart00255
    Location:404547
    TIR; Toll - interleukin 1 - resistance
    cl11960
    Location:26131
    Ig; Immunoglobulin domain
  3. XM_005247434.3XP_005247491.1  

    Conserved Domains (3) summary
    smart00255
    Location:210353
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:59154
    IG_like; Immunoglobulin like
    cl11960
    Location:1441
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    190195381..190338509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)