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IL1R1 interleukin 1 receptor, type I [ Homo sapiens (human) ]

Gene ID: 3554, updated on 26-Aug-2014
Official Symbol
IL1R1provided by HGNC
Official Full Name
interleukin 1 receptor, type Iprovided by HGNC
Primary source
HGNC:5993
See related
Ensembl:ENSG00000115594; HPRD:00994; MIM:147810; Vega:OTTHUMG00000130783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
Summary
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
See IL1R1 in Epigenomics, MapViewer
Location:
2q12
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (102070376..102179874)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102686836..102796334)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene interleukin 1 receptor, type II Neighboring gene interleukin 1 receptor-like 2 Neighboring gene protein FAM183A-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
NHGRI GWA Catalog
Genome-wide association study to identify genetic determinants of severe asthma.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of IL-1RA in uninfected mononuclear cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
    Hypertrophy Model, organism-specific biosystem
    Hypertrophy Model
  • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
  • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL1-mediated signaling events, organism-specific biosystem
    IL1-mediated signaling events
  • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL12-mediated signaling events, organism-specific biosystem
    IL12-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Monoamine Transport, organism-specific biosystem (from WikiPathways)
    Monoamine Transport, organism-specific biosystem
    Monoamine Transport
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1, Type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
interleukin-1 receptor type 1
Names
interleukin-1 receptor type 1
IL-1R-1
IL-1RT1
IL-1RT-1
interleukin-1 receptor alpha
interleukin-1 receptor type I
CD121 antigen-like family member A
interleukin 1 receptor alpha, type I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000877.3NP_000868.1  interleukin-1 receptor type 1 isoform 1 precursor

    See proteins identical to NP_000868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007271, AL548240, BE144272, BQ021163, HY092388, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778
    Related
    ENSP00000386380, OTTHUMP00000161344, ENST00000410023, OTTHUMT00000253299
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain
  2. NM_001288706.1NP_001275635.1  interleukin-1 receptor type 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK314433, AL548240, BE144272, BQ021163, DA861783, M27492
    Consensus CDS
    CCDS74547.1
    UniProtKB/TrEMBL
    B8ZZW4
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 305
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:378506
    Blast Score: 325
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    102070376..102179874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263932.1XP_005263989.1  

    See proteins identical to XP_005263989.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain
  2. XM_005263929.1XP_005263986.1  

    See proteins identical to XP_005263986.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain
  3. XM_005263931.1XP_005263988.1  

    See proteins identical to XP_005263988.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain
  4. XM_005263930.2XP_005263987.1  

    See proteins identical to XP_005263987.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain
  5. XM_005263934.2XP_005263991.1  

    See proteins identical to XP_005263991.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain
  6. XM_005263933.2XP_005263990.1  

    See proteins identical to XP_005263990.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Blast Score: 345
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Blast Score: 304
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    Blast Score: 150
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:387537
    Blast Score: 352
    TIR; TIR domain
    pfam13927
    Location:225316
    Blast Score: 95
    Ig_3; Immunoglobulin domain

RNA

  1. XR_244889.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    96450676..96560197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    102691224..102800675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)