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    IL1R1 interleukin 1 receptor, type I [ Homo sapiens ]

    Gene ID: 3554, updated on 19-May-2012
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    Summary

    Official Symbol
    IL1R1provided by HGNC
    Official Full Name
    interleukin 1 receptor, type Iprovided by HGNC
    Primary source
    HGNC:5993
    See related
    Ensembl:ENSG00000115594; HPRD:00994; MIM:147810; Vega:OTTHUMG00000130783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
    Summary
    The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q12
    Sequence :
    Chromosome: 2; NC_000002.11 (102770402..102796334)
    See IL1R1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor, type II Neighboring gene AHPA9419 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene interleukin 1 receptor-like 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. In-vivo extravasation induces the expression of interleukin 1 receptor type 1 in human neutrophils. Paulsson JM, et al. Clin Exp Immunol, 2012 Apr. PMID 22385245.
    2. Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis. Mahmoudi M, et al. Eur Cytokine Netw, 2011 Dec. PMID 22285486.
    3. C-Kit controls IL-1β-induced effector functions in HMC-cells. Drube S, et al. Eur J Pharmacol, 2012 Jan 30. PMID 22173128.
    4. IL-1 receptor regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion. Sorenson BS, et al. Mucosal Immunol, 2012 Jan. PMID 22031183.
    5. Ex vivo IL-1 receptor type I expression in human CD4+ T cells identifies an early intermediate in the differentiation of Th17 from FOXP3+ naive regulatory T cells. Raffin C, et al. J Immunol, 2011 Nov 15. PMID 21998454.

    See all (217) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. data demonstrated that IL-1R polymorphism is associated with susceptibility to ankylosing spondylitis
      Title: Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis.
    2. Data suggest that c-kit is an important regulator of IL-1 receptor 1/IL-1beta signaling and effector functions in mast cells; such signaling is IL-relevant for IL-6 release.
      Title: C-Kit controls IL-1β-induced effector functions in HMC-cells.
    3. regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion
      Title: IL-1 receptor regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion.
    4. findings demonstrate that neutrophils express IL-1R1 and that IL-1R1 is induced following extravasation and exists in a mobile intracellular compartment
      Title: In-vivo extravasation induces the expression of interleukin 1 receptor type 1 in human neutrophils.
    5. Data sshow that variants in SFTPD, CD46 and IL1R1 are associated with IPD in both EA and AA.
      Title: Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease.
    6. IL-1RI expression in regulatory T (Treg)cells identifies a subpopulation at an early stage of differentiation.
      Title: Ex vivo IL-1 receptor type I expression in human CD4+ T cells identifies an early intermediate in the differentiation of Th17 from FOXP3+ naive regulatory T cells.
    7. This study found for the first time an epigallocatechin gallate-induced downregulation of the IL-1RI expression possibly being caused by NF-kappaB inhibition.
      Title: EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.
    8. IL-1RI expression was not altered in endometrioid carcinoma cells in comparison with endometrial cells, clear-cells, serous and mucinous ovarian cancer cells.
      Title: Endometrioid ovarian cancer and endometriotic cells exhibit the same alteration in the expression of interleukin-1 receptor II: to a link between endometriosis and endometrioid ovarian cancer.
    9. Interleukin-1 receptor-mediated inflammation impairs the heat shock response of human mesothelial cells
      Title: Interleukin-1 receptor-mediated inflammation impairs the heat shock response of human mesothelial cells.
    10. No association was found between recurrent spontaneous abortion and gene polymorphisms in the interleukin-1 receptor 1 gene.
      Title: Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion.
    Submit: New GeneRIF Correction See all (66)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of IL-1RA in uninfected mononuclear cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000868.1 NP_067681.1 TICAM2    BIND  PubMed TIRP interacts with IL-1R. 
    P14778 P01583 IL1A    HPRD  PubMed  
    P14778 P01584 IL1B    HPRD  PubMed  
    P14778 Q8WWZ1 IL1F10    HPRD  PubMed  
    P14778 Q9NPH3 IL1RAP    HPRD  PubMed  
    P14778 P18510 IL1RN    HPRD  PubMed  
    P14778 O43187 IRAK2    HPRD  PubMed  
    P14778 Q99836 MYD88    HPRD  PubMed  
    P14778 P27986 PIK3R1    HPRD  PubMed  
    P14778 Q6IA17 SIGIRR    HPRD  PubMed  
    P14778 Toll like receptor adaptor molecule 2 TICAM2    HPRD  PubMed  
    P14778 Q9H0E2 TOLLIP    HPRD  PubMed  
    BioGRID:109770 BioGRID:109769 IL1B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109770 BioGRID:109771 IL1RAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:109772 IL1RN    BioGRID  PubMed Co-crystal Structure 
    BioGRID:109770 BioGRID:109865 IRAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:110700 MYD88    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:121873 SIGIRR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:119978 TOLLIP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:115354 TOM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109770 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
      Hypertrophy Model, organism-specific biosystem
      Hypertrophy Model
    • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
    • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL1-mediated signaling events, organism-specific biosystem
      IL1-mediated signaling events
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Monoamine Transport, organism-specific biosystem (from WikiPathways)
      Monoamine Transport, organism-specific biosystem
      Monoamine Transport
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-1 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    interleukin-1, Type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    interleukin-1-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ovulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    interleukin-1 receptor type 1
    Names
    interleukin-1 receptor type 1
    IL-1R-1
    IL-1RT1
    IL-1RT-1
    antigen CD121a
    interleukin receptor 1
    interleukin-1 receptor alpha
    interleukin-1 receptor type I
    CD121 antigen-like family member A
    interleukin 1 receptor alpha, type I
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000877.2 → NP_000868.1  interleukin-1 receptor type 1 precursor

      Status: REVIEWED

      Source sequence(s)
      M27492
      Consensus CDS
      CCDS2055.1
      UniProtKB/Swiss-Prot
      P14778
      Related
      ENSP00000233946, ENST00000233946
      Conserved Domains (4) summary
      cd05756
      Location:24 – 113
      Blast Score: 337
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128 – 219
      Blast Score: 309
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cl11960
      Location:234 – 328
      Blast Score: 97
      Ig; Immunoglobulin domain
      cl15770
      Location:387 – 536
      Blast Score: 345
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      102770402..102796334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      96534264..96560197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007271.4 AAX81988.1
    genomic AF531102.1 AAM88423.1
    genomic CH471127.2 EAX01799.1
    genomic JA738563.1 CCF76934.1
    mRNA AK026803.1 None
    mRNA AK314433.1 None
    mRNA BC067506.1 AAH67506.1
    mRNA BC067507.1 AAH67507.1
    mRNA BC067508.1 AAH67508.1
    mRNA BC075062.2 AAH75062.1
    mRNA BC075063.2 AAH75063.1
    mRNA M27492.1 AAA59137.1
    mRNA X16896.1 CAA34773.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14778.1 GenPept UniProtKB/Swiss-Prot:P14778
    Q6NWP5 GenPept UniProtKB/TrEMBL:Q6NWP5
    Q6NWP6 GenPept UniProtKB/TrEMBL:Q6NWP6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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