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    ap apterous [ Drosophila melanogaster ]

    Gene ID: 35509, updated on 10-May-2012
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    Summary

    Official Symbol
    approvided by Flybase
    Official Full Name
    apterousprovided by Flybase
    Primary source
    FLYBASE:FBgn0000099
    Locus tag
    Dmel_CG8376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ap; AP; Apt; blt; CG8376; Dmel\CG8376; LIM; S-2a; trw; Xa
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    Genomic context

    Location :
    41F8-41F8; 2-55.2 cM
    Sequence :
    Chromosome: 2R; NT_033778.3 (1593707..1614335, complement)
    See ap in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG17337 gene product from transcript CG17337-RA Neighboring gene vulcan Neighboring gene lethal (2) 09851 Neighboring gene CG34200 gene product from transcript CG34200-RA Neighboring gene CG7791 gene product from transcript CG7791-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Pleiotropic consequences of misexpression of the developmentally active and stress-inducible non-coding hsrω gene in Drosophila. Mallik M, et al. J Biosci, 2011 Jun. PMID 21654081.
    2. Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. Goto J, et al. J Neurosci, 2011 Apr 6. PMID 21471381.
    3. The female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Chatterjee SS, et al. Development, 2011 Mar. PMID 21343364.
    4. A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. Gabilondo H, et al. Mech Dev, 2011 Mar-Apr. PMID 21236339.
    5. Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. Morante J, et al. Development, 2011 Feb. PMID 21208993.

    See all (295) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The AP and NAT activities in ap56f females were significantly lower than in Canton S females in the norm
      Title: [Effect of the apterous56f mutation on N-acetyltransferase and alkaline phosphatase activities in Drosophila melanogaster females].
    2. A new instance of transvection at the Drosophila apterous (ap) locus, is reported.
      Title: Enhancer blocking and transvection at the Drosophila apterous locus.
    3. necessary for expression of the Leucokinin neuropeptide in a pair of brain neurons located in the lateral horn region of the protocerebrum
      Title: Neurosecretory identity conferred by the apterous gene: lateral horn leucokinin neurons in Drosophila.
    4. in the absence of vg, the IFM developmental program switches into the DFM developmental program.DFM development requires key regulatory genes such as cut (ct) and apterous (ap), whereas IFM development requires vestigial (vg).
      Title: Control of apterous by vestigial drives indirect flight muscle development in Drosophila.
    5. contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the wing
      Title: A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing.
    6. Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing
      Title: Osa modulates the expression of Apterous target genes in the Drosophila wing.
    7. Apterous (Ap, a selector protein), and the Notch and Wingless (Wg) signaling pathways, can sequentially control wing development through direct regulation of Ser expression in instar stages
      Title: Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development.
    8. homeodomain proteins Bar and Aristaless and the LIM-HOM proteins Apterous and Lim1 regulate distal leg development
      Title: Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development.
    9. in brain development, Ap is required for correct axon guidance and fasciculation of interneurons, and Ap-expressing cells may also be involved in the brain neuroendocrine system.
      Title: Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila.
    10. Data show that normal cell proliferation is necessary for apterous expression at the level of the dorso-ventral boundary, which is mediated by vestigial, interacting in a dose-dependent way with apterous.
      Title: Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61416 BioGRID:59159 Bx    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:61416 BioGRID:63418 Chi    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Two-hybrid 
    BioGRID:61416 BioGRID:67310 Dl    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:69563 Dr    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:67421 H    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:61171 Lim3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:68163 Ser    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:57896 bi    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:61416 BioGRID:64838 caps    BioGRID  PubMed Phenotypic Suppression 
    NP_523611.1 dimm    BIND  PubMed Dimm interacts with Ap. 
    BioGRID:61416 BioGRID:65569 fng    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:57591 fz3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:58660 mew    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:77545 p53    BioGRID  PubMed Affinity Capture-Western 
    NP_524403.1 sqz    BIND  PubMed Sqz interacts with Ap. 
    BioGRID:61416 BioGRID:67186 sr    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:61416 BioGRID:61139 tup    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:62192 vg    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:64117 vn    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:61416 BioGRID:60155 wg    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
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    General gene information

    Homology

    • Homologs of the ap gene: The ap gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    mobile_element

    • Loc: c1605530-1605459 mobile_element_type = transposon:INE-1{}5107
    • Loc: c1610018-1609755 mobile_element_type = transposon:INE-1{}5122
    • Loc: c1612302-1611440 mobile_element_type = transposon:INE-1{}5123

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell fate commitment NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    dorsal/ventral lineage restriction, imaginal disc TAS
    Traceable Author Statement
    more info
    		 PubMed 
    dorsal/ventral pattern formation, imaginal disc TAS
    Traceable Author Statement
    more info
    		 PubMed 
    haltere disc morphogenesis NAS
    Non-traceable Author Statement
    more info
    		  
    histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived leg segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    leg disc proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    muscle organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    wing disc dorsal/ventral pattern formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    wing disc morphogenesis NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG8376 gene product from transcript CG8376-RA
    Names
    CG8376-PA
    CG8376-PB
    CG8376-PC
    CG8376-PD
    ap-PA
    ap-PB
    ap-PC
    ap-PD
    apterous
    no-wings
    tornwing
    xasta
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      1593707..1614335, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165445.3 → NP_724428.1  apterous, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29673
      Related
      FBpp0085394, FBtr0086058
      Conserved Domains (3) summary
      cd00086
      Location:374 – 426
      Blast Score: 175
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cd09369
      Location:148 – 201
      Blast Score: 277
      LIM1_Lhx2_Lhx9; The first LIM domain of Lhx2 and Lhx9 family
      cd09377
      Location:206 – 264
      Blast Score: 297
      LIM2_Lhx2_Lhx9; The second LIM domain of Lhx2 and Lhx9 family

    2. NM_001169588.1 → NP_001163059.1  apterous, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGY0
      UniProtKB/Swiss-Prot
      P29673
      Related
      FBpp0289732, FBtr0300505
      Conserved Domains (2) summary
      cd00086
      Location:151 – 203
      Blast Score: 179
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cl02475
      Location:1 – 41
      Blast Score: 224
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

    3. NM_078897.4 → NP_523621.2  apterous, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGY0
      UniProtKB/Swiss-Prot
      P29673
      Related
      FBpp0085395, FBtr0086059
      Conserved Domains (2) summary
      cd00086
      Location:151 – 203
      Blast Score: 179
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cl02475
      Location:1 – 41
      Blast Score: 224
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

    4. NM_001169587.1 → NP_001163058.1  apterous, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGX9
      UniProtKB/Swiss-Prot
      P29673
      Related
      FBpp0289731, FBtr0300504
      Conserved Domains (3) summary
      cd00086
      Location:373 – 425
      Blast Score: 176
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cd09369
      Location:147 – 200
      Blast Score: 277
      LIM1_Lhx2_Lhx9; The first LIM domain of Lhx2 and Lhx9 family
      cd09377
      Location:205 – 263
      Blast Score: 297
      LIM2_Lhx2_Lhx9; The second LIM domain of Lhx2 and Lhx9 family
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA M92841.1 AAA28673.1
    genomic X65158.1 CAA46276.1
    genomic AE013599.4 AAF57314.1
    mRNA BT005201.1 AAO61758.1
    genomic AE013599.4 AAM68357.2
    genomic AE013599.4 ACZ94339.1
    genomic AE013599.4 ACZ94338.1
    mRNA AY069815.1 AAL39960.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29673.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content