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IK IK cytokine, down-regulator of HLA II [ Homo sapiens (human) ]

Gene ID: 3550, updated on 17-Mar-2015
Official Symbol
IKprovided by HGNC
Official Full Name
IK cytokine, down-regulator of HLA IIprovided by HGNC
Primary source
HGNC:HGNC:5958
See related
Ensembl:ENSG00000113141; HPRD:02771; MIM:600549; Vega:OTTHUMG00000163374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RED; CSA2
Summary
The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
Orthologs
See IK in MapViewer
Location:
5q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (140647799..140662480)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140027384..140042065)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene CD14 molecule Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa Neighboring gene microRNA 3655 Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase Neighboring gene histidyl-tRNA synthetase 2, mitochondrial

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with IK cytokine, down-regulator of HLA II (IK; RED) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC59741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein Red
Names
protein Red
IK factor
RD element
chondrosarcoma-associated protein 2
cytokine IK
prer protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006083.3NP_006074.2  protein Red

    See proteins identical to NP_006074.2

    Status: REVIEWED

    Source sequence(s)
    AF182645, BC013005, BC071964
    Consensus CDS
    CCDS47280.1
    UniProtKB/Swiss-Prot
    Q13123
    UniProtKB/TrEMBL
    Q95HA6
    UniProtKB/TrEMBL
    Q9UK43
    Related
    ENSP00000396301, OTTHUMP00000223684, ENST00000417647, OTTHUMT00000372897
    Conserved Domains (2) summary
    pfam07807
    Location:445557
    RED_C; RED-like protein C-terminal region
    pfam07808
    Location:76295
    RED_N; RED-like protein N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    140647799..140662480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    139460619..139475314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)