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    sxc super sex combs [ Drosophila melanogaster ]

    Gene ID: 35486, updated on 10-May-2012
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    Summary

    Official Symbol
    sxcprovided by Flybase
    Official Full Name
    super sex combsprovided by Flybase
    Primary source
    FLYBASE:FBgn0261403
    Locus tag
    Dmel_CG10392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04245; CG10392; Dmel\CG10392; l(2)02637; l(2)NC130; Ogt; OGT; P1201; Sxc; SXC; sxc/Ogt
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    Genomic context

    Location :
    41C1-41C2; 2-55.3 cM
    Sequence :
    Chromosome: 2R; NT_033778.3 (1194756..1216986)
    See sxc in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CG2682 gene product from transcript CG2682-RB Neighboring gene CG10465 gene product from transcript CG10465-RA Neighboring gene CG10395 gene product from transcript CG10395-RA Neighboring gene CG30441 gene product from transcript CG30441-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Sakaidani Y, et al. Nat Commun, 2011 Dec 13. PMID 22158438.
    2. The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. Ashton-Beaucage D, et al. Cell, 2010 Oct 15. PMID 20946983.
    3. Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis. Sekine O, et al. J Biol Chem, 2010 Dec 3. PMID 20926386.
    4. Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Sinclair DA, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19666537.
    5. Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Gambetta MC, et al. Science, 2009 Jul 3. PMID 19478141.

    See all (51) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Here is presented a novel O-GlcNAc transferase (OGT), EOGT, responsible for extracellular O-linked-N-acetylglucosamine acylation.
      Title: O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions.
    2. study found that the super sex combs (sxc)gene encodes O-linked N-acetylglucosamine transferase (Ogt); Polycomb repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic
      Title: Essential role of the glycosyltransferase sxc/Ogt in polycomb repression.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61400 BioGRID:61251 CG10664    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:64028 CG11350    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:65104 CG13043    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:62016 CG13204    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:57586 CG13362    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:63206 CG2852    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:60083 CG31635    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:58682 CG34324    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:65115 CG4998    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:65342 CG6843    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:61621 CSN4    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:67322 Dys    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:64797 Hip1    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:61670 Lcp1    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:61671 Lcp2    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:60577 Stam    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:64396 Zasp66    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:63159 ari-2    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:64769 eyg    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:61180 l(2)37Cg    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:62642 mbl    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:65587 park    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:68973 pie    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:68829 sns    BioGRID  PubMed Two-hybrid 
    BioGRID:61400 BioGRID:68659 toy    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the sxc gene: The sxc gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and A.thaliana.

    Pathways from BioSystems

    • Other types of O-glycan biosynthesis, organism-specific biosystem (from KEGG)
      Other types of O-glycan biosynthesis, organism-specific biosystemO-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or th...
    • Other types of O-glycan biosynthesis, conserved biosystem (from KEGG)
      Other types of O-glycan biosynthesis, conserved biosystemO-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or th...

    mobile_element

    • Loc: 1196619-1199002 mobile_element_type = transposon:1360{}644
    • Loc: 1199110-1199387 mobile_element_type = transposon:FB{}3670
    • Loc: 1200648-1202779 mobile_element_type = transposon:Rt1b{}3595
    • Loc: 1202929-1203223 mobile_element_type = transposon:I{}3122
    • Loc: 1207221-1207337 mobile_element_type = transposon:Transpac{}3603
    • Loc: 1208418-1208517 mobile_element_type = transposon:INE-1{}3176
    • Loc: 1208539-1208607 mobile_element_type = transposon:INE-1{}3178
    • Loc: 1210129-1210223 mobile_element_type = transposon:INE-1{}3179
    • Loc: 1210968-1211023 mobile_element_type = transposon:ninja-Dsim-like{}3776
    • Loc: 1211415-1211690 mobile_element_type = transposon:INE-1{}3180
    • Loc: 1211724-1211829 mobile_element_type = transposon:INE-1{}3182
    • Loc: 1215600-1215925 mobile_element_type = transposon:INE-1{}3195

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring glycosyl groups NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		  
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    General protein information

    Preferred Names
    CG10392 gene product from transcript CG10392-RB
    Names
    CG10392-PA
    CG10392-PB
    CG10392-PC
    O-glycosyltransferase
    O-linked N-acetylglucosamine transferase
    lethal (2) NC130
    super sex combs
    sxc-PA
    sxc-PB
    sxc-PC
    NP_523620.1
    NP_724406.1
    NP_724407.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      1194756..1216986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078896.2 → NP_523620.1  super sex combs, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJA9
      Related
      FBpp0085420, FBtr0086084
      Conserved Domains (5) summary
      cd00189
      Location:255 – 354
      Blast Score: 225
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      COG3914
      Location:394 – 739
      Blast Score: 412
      Spy; Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]
      pfam13414
      Location:286 – 351
      Blast Score: 157
      TPR_11; TPR repeat
      pfam13844
      Location:584 – 1044
      Blast Score: 2242
      Glyco_transf_41; Glycosyl transferase family 41
      cl02429
      Location:220 – 253
      Blast Score: 99
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...

    2. NM_165426.1 → NP_724406.1  super sex combs, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJA9
      Related
      FBpp0085421, FBtr0086085
      Conserved Domains (5) summary
      cd00189
      Location:255 – 354
      Blast Score: 225
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      COG3914
      Location:394 – 739
      Blast Score: 412
      Spy; Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]
      pfam13414
      Location:286 – 351
      Blast Score: 157
      TPR_11; TPR repeat
      pfam13844
      Location:584 – 1044
      Blast Score: 2242
      Glyco_transf_41; Glycosyl transferase family 41
      cl02429
      Location:220 – 253
      Blast Score: 99
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...

    3. NM_165427.1 → NP_724407.1  super sex combs, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJA9
      Related
      FBpp0085422, FBtr0086086
      Conserved Domains (5) summary
      cd00189
      Location:255 – 354
      Blast Score: 225
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      COG3914
      Location:394 – 739
      Blast Score: 412
      Spy; Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]
      pfam13414
      Location:286 – 351
      Blast Score: 157
      TPR_11; TPR repeat
      pfam13844
      Location:584 – 1044
      Blast Score: 2242
      Glyco_transf_41; Glycosyl transferase family 41
      cl02429
      Location:220 – 253
      Blast Score: 99
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF57338.1
    genomic AE013599.4 AAG22338.1
    genomic AE013599.4 AAG22339.1
    mRNA AF217788.1 AAF32311.1
    mRNA BT032865.1 ACD81879.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3X6.1 GenPept
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    Additional Links

    Gene LinkOut

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