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    gus gustavus [ Drosophila melanogaster ]

    Gene ID: 35478, updated on 4-Feb-2012
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    Summary

    Official Symbol
    gusprovided by Flybase
    Official Full Name
    gustavusprovided by Flybase
    Primary source
    FLYBASE:FBgn0026238
    Locus tag
    Dmel_CG2944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A11; CG2944; CG2946; Dmel\CG2944; dmSSB4; Gus; GUS; GUSTAVUS; i25
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    Genomic context

    Location :
    41D3-41D3
    Sequence :
    Chromosome: 2R; NT_033778.3 (1004715..1015817, complement)
    See gus in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene Troponin C at 41C Neighboring gene CG3107 gene product from transcript CG3107-RA Neighboring gene CG3136 gene product from transcript CG3136-RA Neighboring gene CG33554 gene product from transcript CG33554-RE

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826.
    2. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Lunardi A, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308539.
    3. Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis. Kugler JM, et al. PLoS One, 2010 Feb 4. PMID 20140218.
    4. Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. Kugler JM, et al. Mol Cell Biol, 2010 Apr. PMID 20123973.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.
      Title: Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
    2. We report the crystal structure of the B30.2/SPRY domain of a SPRY domain-containing SOCS box (SSB) protein, GUSTAVUS, complexed with a 20 amino acid peptide derived from the RNA helicase VASA, revealing how these domains recognize target proteins.
      Title: Structural basis for protein recognition by B30.2/SPRY domains.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61396 BioGRID:70573 Adf1    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67008 Akt1    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:64801 Atg1    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:61126 CG10348    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:72526 CG13631    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:61445 CG14589    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:60815 CG16890    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:61776 CG42382    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67603 CG5376    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67527 CG6800    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:66220 CG8223    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:61339 CG9248    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:62567 Cdk4    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:64701 CycA    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:68567 CycG    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:65669 CycH    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:63921 CycJ    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:58935 Cyp1    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:61336 E2f2    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:63083 Egfr    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:62899 Elongin-C    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:64793 Klc    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67630 Nup133    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:62088 Oda    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:64739 RhoGAP68F    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:78269 RpL38    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:66357 RpS29    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:65629 SAK    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67396 Sirt2    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:62325 Sox15    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67158 ald    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67612 bond    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:60206 cdc14    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67428 cdc2c    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:60088 cup    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:65326 ftz-f1    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:67231 koko    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:59717 lilli    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:65288 mus304    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:77545 p53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:61396 BioGRID:68973 pie    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:65883 rev7    BioGRID  PubMed Two-hybrid 
    BioGRID:61396 BioGRID:62080 skpB    BioGRID  PubMed Two-hybrid 
    NP_731924.1 stumps    BIND  PubMed Dof interacts with an unspecified isoform of Gus. 
    BioGRID:61396 BioGRID:68659 toy    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the gus gene: The gus gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    mobile_element

    • Loc: c1005721-1005446 mobile_element_type = transposon:INE-1{}2086
    • Loc: c1007059-1006808 mobile_element_type = transposon:INE-1{}2087
    • Loc: c1012503-1012387 mobile_element_type = transposon:INE-1{}2917
    • Loc: c1014225-1013255 mobile_element_type = transposon:1360{}2914
    • Loc: c1015423-1014255 mobile_element_type = transposon:INE-1{}2912

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    oocyte anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG2944 gene product from transcript CG2944-RB
    Names
    CG2944-PA
    CG2944-PB
    CG2944-PC
    CG2944-PD
    CG2944-PE
    CG2944-PF
    gus-PA
    gus-PB
    gus-PC
    gus-PD
    gus-PE
    gus-PF
    gustavus
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      1004715..1015817, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136314.2 → NP_610158.2  gustavus, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6D7
      Related
      FBpp0088698, FBtr0089757
      Conserved Domains (2) summary
      cd03718
      Location:298 – 340
      Blast Score: 167
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:161 – 292
      Blast Score: 191
      SPRY; SPRY domain

    2. NM_165418.1 → NP_724398.1  gustavus, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUY1
      Related
      FBpp0088697, FBtr0089756
      Conserved Domains (2) summary
      cd03718
      Location:304 – 346
      Blast Score: 168
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:167 – 298
      Blast Score: 191
      SPRY; SPRY domain

    3. NM_165419.1 → NP_724399.1  gustavus, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6D9
      Related
      FBpp0088694, FBtr0089753
      Conserved Domains (2) summary
      cd03718
      Location:306 – 348
      Blast Score: 167
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:169 – 300
      Blast Score: 191
      SPRY; SPRY domain

    4. NM_165421.1 → NP_724401.1  gustavus, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6D7
      Related
      FBpp0088696, FBtr0089755
      Conserved Domains (2) summary
      cd03718
      Location:298 – 340
      Blast Score: 167
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:161 – 292
      Blast Score: 191
      SPRY; SPRY domain

    5. NM_165420.1 → NP_724400.1  gustavus, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6E0
      Related
      FBpp0088695, FBtr0089754
      Conserved Domains (2) summary
      cd03718
      Location:318 – 360
      Blast Score: 168
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:181 – 312
      Blast Score: 188
      SPRY; SPRY domain

    6. NM_165422.1 → NP_724402.1  gustavus, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6E2
      Related
      FBpp0088693, FBtr0089752
      Conserved Domains (2) summary
      cd03718
      Location:236 – 278
      Blast Score: 170
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:99 – 230
      Blast Score: 190
      SPRY; SPRY domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAM68374.1
    mRNA BT089043.1 ACU12389.1
    genomic AE013599.4 AAG22337.2
    mRNA AY119609.1 AAM50263.1
    genomic AE013599.4 AAF57346.1
    mRNA BT099916.1 ACX32987.1
    genomic AE013599.4 AAM68372.1
    genomic AE013599.4 AAM68373.1
    genomic AE013599.4 AAF57347.2
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q8MLL7.1 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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