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EF2 Elongation factor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35422, updated on 10-May-2016
Official Symbol
EF2provided by FlyBase
Official Full Name
Elongation factor 2provided by FlyBase
Primary source
FLYBASE:FBgn0000559
Locus tag
Dmel_CG2238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.44; CG2238; chr2L:21668915..21669164; clone 1.44; Dmel\CG2238; eEF2; EF-2; EF-2b; eF2; Ef2; ef2b; Ef2b; EF2b
Location:
39E7-39E7
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.07 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21677913..21682164, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21677913..21682164, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cullin 2 Neighboring gene CG2225 gene product from transcript CG2225-RH Neighboring gene ncRNA Neighboring gene small non-messenger RNA 254 Neighboring gene no long nerve cord Neighboring gene steppke

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
translation elongation factor activity NAS
Non-traceable Author Statement
more info
 
Process Evidence Code Pubs
mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
 
translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid particle IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CG2238 gene product from transcript CG2238-RD
Names
CG2238-PA
CG2238-PC
CG2238-PD
EF2-PA
EF2-PC
EF2-PD
elongation factor 2
elongation factor 2b
eukaryotic translation elongation factor 2b

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21677913..21682164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165394.3NP_724357.2  elongation factor 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724357.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13060
    Related
    FBpp0305182, FBtr0332966
    Conserved Domains (6) summary
    cd01885
    Location:20236
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:560732
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd03700
    Location:380473
    eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
    cd04096
    Location:728807
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1844
    PTZ00416; elongation factor 2; Provisional
    pfam14492
    Location:489551
    EFG_II; Elongation Factor G, domain II
  2. NM_165395.2NP_724358.2  elongation factor 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724358.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13060
    Related
    FBpp0085266, FBtr0085912
    Conserved Domains (6) summary
    cd01885
    Location:20236
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:560732
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd03700
    Location:380473
    eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
    cd04096
    Location:728807
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1844
    PTZ00416; elongation factor 2; Provisional
    pfam14492
    Location:489551
    EFG_II; Elongation Factor G, domain II
  3. NM_080366.3NP_525105.2  elongation factor 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525105.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13060
    Related
    FBpp0085265, FBtr0085911
    Conserved Domains (6) summary
    cd01885
    Location:20236
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:560732
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd03700
    Location:380473
    eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
    cd04096
    Location:728807
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1844
    PTZ00416; elongation factor 2; Provisional
    pfam14492
    Location:489551
    EFG_II; Elongation Factor G, domain II