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    Cul-2 Cullin-2 [ Drosophila melanogaster ]

    Gene ID: 35420, updated on 26-Jan-2012
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    Summary

    Official Symbol
    Cul-2provided by Flybase
    Official Full Name
    Cullin-2provided by Flybase
    Primary source
    FLYBASE:FBgn0032956
    Locus tag
    Dmel_CG1512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1512; cul-2; Cul2; CUL2; DMcul-2; Dmel\CG1512; l(2)02074
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    Genomic context

    Location :
    39E3-39E6
    Sequence :
    Chromosome: 2L; NT_033779.4 (21658752..21663218)
    See Cul-2 in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene Decondensation factor 31 Neighboring gene CG1506 gene product from transcript CG1506-RA Neighboring gene CG2225 gene product from transcript CG2225-RC Neighboring gene small non-messenger RNA 254 Neighboring gene Elongation factor 2b

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila. Ayyub C. J Genet, 2011 Aug. PMID 21869472.
    2. Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping. Reynolds PJ, et al. PLoS One, 2008 Aug 13. PMID 18698375.
    3. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    4. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    5. p53 directs focused genomic responses in Drosophila. Akdemir F, et al. Oncogene, 2007 Aug 9. PMID 17310982.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila
      Title: Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61365 BioGRID:63934 CG1120    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:59058 CG12432    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:67185 CG14317    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:72486 CG17508    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:57563 CG18273    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:58683 CG32635    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:77797 CG33275    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:60146 CG4496    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:64118 CG5568    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:60446 CG5731    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:62268 CG6191    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:66545 CG6923    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:65672 CG7148    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:66550 ClC-a    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:68567 CycG    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:68286 Doa    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:61444 EcR    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:66726 Lip3    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:63832 MEP-1    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:69445 Pp4-19C    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:57582 Roc1a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:61365 BioGRID:67915 Smg6    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:60212 TwdlE    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:57875 Xpac    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:61832 dap    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:61353 dimm    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:57796 dwg    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:66618 lig3    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:59482 lwr    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:62946 mus209    BioGRID  PubMed Two-hybrid 
    BioGRID:61365 BioGRID:68607 pan    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Homology

    • Homologs of the Cul-2 gene: The Cul-2 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Pathways from BioSystems

    • ECV complex, organism-specific biosystem (from KEGG)
      ECV complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    		  
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    CG1512 gene product from transcript CG1512-RA
    Names
    CG1512-PA
    CG1512-PB
    Cul-2-PA
    Cul-2-PB
    Cullin-2
    cul-2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      21658752..21663218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165390.1 → NP_724352.1  Cullin-2, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9R2
      Related
      FBpp0085254, FBtr0085899
      Conserved Domains (3) summary
      smart00182
      Location:436 – 575
      Blast Score: 482
      CULLIN; Cullin
      pfam00888
      Location:14 – 653
      Blast Score: 1395
      Cullin; Cullin family
      cl11186
      Location:680 – 747
      Blast Score: 257
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_136273.2 → NP_610117.1  Cullin-2, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9R2
      Related
      FBpp0085255, FBtr0085900
      Conserved Domains (3) summary
      smart00182
      Location:436 – 575
      Blast Score: 482
      CULLIN; Cullin
      pfam00888
      Location:14 – 653
      Blast Score: 1395
      Cullin; Cullin family
      cl11186
      Location:680 – 747
      Blast Score: 257
      Cullin_Nedd8; Cullin protein neddylation domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 AAG22124.2
    mRNA AY061434.1 AAL28982.1
    genomic AE014134.5 AAF57224.3
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q9V9R2.1 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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