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    KLK3 kallikrein-related peptidase 3 [ Homo sapiens ]

    Gene ID: 354, updated on 4-Feb-2012

    Summary

    Official Symbol
    KLK3provided by HGNC
    Official Full Name
    kallikrein-related peptidase 3provided by HGNC
    Primary source
    HGNC:6364
    See related
    Ensembl:ENSG00000142515; HPRD:01461; MIM:176820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APS; PSA; hK3; KLK2A1
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    19q13.41
    Sequence :
    Chromosome: 19; NC_000019.9 (51358171..51364020)
    See KLK3 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene kallikrein 1 Neighboring gene kallikrein-related peptidase 15 Neighboring gene kallikrein-related peptidase 2 Neighboring gene kallikrein pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AF394907.1 NP_000035.2 AR    BIND  PubMed AR interacts with p-PSA. 
    AF394907.1 NP_000928.1 POLR2A    BIND  PubMed Pol II interacts with p-PSA. 
    NC_000019.8 NP_001895.1 CTNNB1    BIND  PubMed CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter. 
    NC_000019.8 KAT5    BIND  PubMed HTATIP (Tip60) interacts with the KLK3 (PSA) promoter. 
    NC_000019.8 NP_003698.1 RUVBL1    BIND  PubMed RUVBL1 (pontin) interacts with the KLK3 (PSA) promoter. 
    P07288 P01023 A2M    HPRD  PubMed  
    P07288 P02768 ALB    HPRD  PubMed  
    P07288 P19235 EPOR    HPRD  PubMed  
    P07288 P02751 FN1    HPRD  PubMed  
    P07288 P17936 IGFBP3    HPRD  PubMed  
    P07288 P00747 PLG    HPRD  PubMed  
    P07288 P12272 PTHLH    HPRD  PubMed  
    P07288 P20742 PZP    HPRD  PubMed  
    P07288 P04279 SEMG1    HPRD  PubMed  
    P07288 Q02383 SEMG2    HPRD  PubMed  
    P07288 P01009 SERPINA1    HPRD  PubMed  
    P07288 P01011 SERPINA3    HPRD  PubMed  
    P07288 P05154 SERPINA5    HPRD  PubMed  
    P07288 P03973 SLPI    HPRD  PubMed  
    BioGRID:106850 BioGRID:106524 A2M    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106850 BioGRID:111283 SERPINA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106850 BioGRID:111135 SERPINA5    BioGRID  PubMed Affinity Capture-Western; Co-purification 

    General gene information

    Markers

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    prostate-specific antigen
    Names
    prostate-specific antigen
    seminin
    P-30 antigen
    kallikrein-3
    semenogelase
    gamma-seminoprotein
    prostate specific antigen
    NP_001025218.1
    NP_001025219.1
    NP_001025221.1
    NP_001639.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011653.1 RefSeqGene

      Range
      5001..10850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001030047.1NP_001025218.1  prostate-specific antigen isoform 3 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at the end of a coding exon, that causes a frameshift. The resulting isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011523, BC005307, M21896
      Consensus CDS
      CCDS33083.1
      UniProtKB/TrEMBL
      G3XAE3
      UniProtKB/Swiss-Prot
      P07288
      UniProtKB/TrEMBL
      Q15096
      Related
      ENSP00000353829, ENST00000360617
      Conserved Domains (1) summary
      cd00190
      Location:25210
      Blast Score: 446
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001030048.1NP_001025219.1  prostate-specific antigen isoform 4 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site at the end of a coding exon. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC011523, BC005307, BQ932072
      Consensus CDS
      CCDS46155.1
      UniProtKB/TrEMBL
      G3V0H4
      UniProtKB/Swiss-Prot
      P07288
      Related
      ENSP00000393628, ENST00000422986
      Conserved Domains (1) summary
      cd00190
      Location:25213
      Blast Score: 514
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_001030050.1NP_001025221.1  prostate-specific antigen isoform 6 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (6) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011523, BF679511
      Consensus CDS
      CCDS46156.1
      UniProtKB/TrEMBL
      C9JXH3
      Related
      ENSP00000401523, ENST00000435152
      Conserved Domains (1) summary
      cl00149
      Location:2569
      Blast Score: 163
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. NM_001648.2NP_001639.1  prostate-specific antigen isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1) of this protein.
      Source sequence(s)
      X05332
      Consensus CDS
      CCDS12807.1
      UniProtKB/Swiss-Prot
      P07288
      UniProtKB/TrEMBL
      Q546G3
      Related
      ENSP00000314151, ENST00000326003
      Conserved Domains (1) summary
      cd00190
      Location:25256
      Blast Score: 614
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      51358171..51364020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      47693102..47698947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

     

    1. NM_001030049.1: Suppressed sequence

      Description
      NM_001030049.1: This RefSeq was permanently suppressed because it contains non-consensus splice sites that are poorly supported.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011523.3 (25017..25128) None
    genomic AF243527.1 AAG33355.1
    genomic CH471135.1 EAW71922.1
      EAW71923.1
      EAW71924.1
      EAW71925.1
      EAW71926.1
      EAW71927.1
      EAW71928.1
      EAW71929.1
      EAW71930.1
      EAW71931.1
      EAW71932.1
      EAW71933.1
      EAW71934.1
      EAW71935.1
      EAW71936.1
    genomic M24543.1 AAA60193.1
    genomic M27274.1 AAA60192.1
    genomic X13940.1 CAA32123.1
    genomic X13941.1 CAA32124.1
    genomic X13942.1 CAB46487.1
    genomic X13943.1 CAA32126.1
    genomic X13944.1 CAA32127.1
    genomic X14810.1 CAA32915.1
    mRNA AF335477.1 AAL73204.1
    mRNA AF335478.1 AAL73205.1
    mRNA AJ310937.1 CAC41631.1
    mRNA AJ310938.1 CAC41632.1
    mRNA AJ459782.1 CAD30844.1
    mRNA AJ459783.1 CAD30845.1
    mRNA AJ459784.1 CAD30846.1
    mRNA AJ512346.1 CAD54617.1
    mRNA AK312933.1 BAG35776.1
    mRNA AX772834.1 CAE06266.1
    mRNA BC005307.1 AAH05307.1
    mRNA BC050595.2 AAH50595.2
    mRNA BC056665.1 AAH56665.1
    mRNA BF679511.1 None
    mRNA BQ932072.1 None
    mRNA BT019862.1 AAV38665.1
    mRNA DQ641251.1 None
    mRNA M21895.1 AAA59995.1
    mRNA M21896.1 AAA59996.1
    mRNA M21897.1 AAA59997.1
    mRNA M26663.1 AAA58802.1
    mRNA S75755.1 AAD14185.1
    mRNA U17040.1 AAA56764.1
    mRNA X05332.1 CAA28947.1
    mRNA X07730.1 None
    mRNA X75682.1 None
    other-genetic DQ890670.2 ABM81596.1
    other-genetic DQ893851.2 ABM84777.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P07288.2 GenPept UniProtKB/Swiss-Prot:P07288
    Q15096 GenPept UniProtKB/TrEMBL:Q15096
    Q15098 GenPept UniProtKB/TrEMBL:Q15098
    Q546G3 GenPept UniProtKB/TrEMBL:Q546G3
    Q6LDS3 GenPept UniProtKB/TrEMBL:Q6LDS3
    Q8IXI4 GenPept UniProtKB/TrEMBL:Q8IXI4
    Q8NCW4 GenPept UniProtKB/TrEMBL:Q8NCW4
    Q8WTQ8 GenPept UniProtKB/TrEMBL:Q8WTQ8
    Q96A30 GenPept UniProtKB/TrEMBL:Q96A30

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