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    barr barren [ Drosophila melanogaster ]

    Gene ID: 35287, updated on 10-May-2012
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    Summary

    Official Symbol
    barrprovided by Flybase
    Official Full Name
    barrenprovided by Flybase
    Primary source
    FLYBASE:FBgn0014127
    Locus tag
    Dmel_CG10726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38B.3; Barr; Barren; Cap-H; CAP-H; CG10726; dCap-H; Dmel\CG10726
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    Genomic context

    Location :
    38B1-38B2
    Sequence :
    Chromosome: 2L; NT_033779.4 (20058163..20060975, complement)
    See barr in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG10659 gene product from transcript CG10659-RA Neighboring gene short neuropeptide F precursor Neighboring gene loki Neighboring gene valois Neighboring gene brain washing Neighboring gene CG10730 gene product from transcript CG10730-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Pek JW, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21730191.
    2. A role for vasa in regulating mitotic chromosome condensation in Drosophila. Pek JW, et al. Curr Biol, 2011 Jan 11. PMID 21185189.
    3. Expression of the apoptosis inducer gene head involution defective in primordial germ cells of the Drosophila embryo requires eiger, p53, and loki function. Maezawa T, et al. Dev Growth Differ, 2009 May. PMID 19382940.
    4. Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Zhou R, et al. Mol Cell, 2008 Nov 21. PMID 19026789.
    5. Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. Pimenta-Marques A, et al. Dev Biol, 2008 Nov 15. PMID 18801358.

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. analysis of Barren/CAP-H-depleted cells showed that mitotic chromosomes are able to condense but fail to resolve sister chromatids
      Title: The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61258 BioGRID:70921 Abd-B    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:61258 BioGRID:68031 CG5890    BioGRID  PubMed Two-hybrid 
    BioGRID:61258 BioGRID:66435 fau    BioGRID  PubMed Two-hybrid 
    BioGRID:61258 BioGRID:57802 w    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    DNA topoisomerase (ATP-hydrolyzing) activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ectodermal digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitotic sister chromatid segregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    peripheral nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    condensin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    condensin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    condensin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG10726 gene product from transcript CG10726-RA
    Names
    CG10726-PA
    CG10726-PB
    barr-PA
    barr-PB
    barren
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      20058163..20060975, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057758.4 → NP_477106.1  barren, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIP9
      Related
      FBpp0080880
      Conserved Domains (1) summary
      cl14902
      Location:6 – 733
      Blast Score: 1619
      Cnd2; Condensin complex subunit 2

    2. NM_165317.2 → NP_724240.1  barren, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIP9
      Related
      FBpp0080881
      Conserved Domains (1) summary
      cl14902
      Location:6 – 733
      Blast Score: 1619
      Cnd2; Condensin complex subunit 2
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT011474.1 AAR99132.1
    mRNA BT011446.1 AAR99104.1
    genomic AE014134.5 AAN11061.1
    genomic AE014134.5 AAF53866.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIP9.1 GenPept
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    Additional Links

    Gene LinkOut

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