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cyst cysts [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35237, updated on 11-Apr-2024

Summary

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Official Symbol
cystprovided by FlyBase
Official Full Name
cystsprovided by FlyBase
Primary source
FLYBASE:FBgn0032796
Locus tag
Dmel_CG10188
See related
AllianceGenome:FB:FBgn0032796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10188; Cyst; Dmel\CG10188; Dp114/Cysts; Dp114RhoGEF
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Is expressed in adult head; leg; and spermatozoon. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations and retinitis pigmentosa. Orthologous to several human genes including ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
37E4-37E5; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19502335..19508764, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19502335..19508764, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytosolic thiouridylase subunit 2 Neighboring gene second mitotic wave missing Neighboring gene Topoisomerase 3alpha Neighboring gene Hig-anchoring scaffold protein Neighboring gene long non-coding RNA:CR43363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. Plank JL, et al. J Biol Chem, 2005 Feb 4. PMID 15537633
  2. Crumbs complex-directed apical membrane dynamics in epithelial cell ingression. Simões S, et al. J Cell Biol, 2022 Jul 4. PMID 35588693, Free PMC Article
  3. Distinct RhoGEFs Activate Apical and Junctional Contractility under Control of G Proteins during Epithelial Morphogenesis. Garcia De Las Bayonas A, et al. Curr Biol, 2019 Oct 21. PMID 31522942, Free PMC Article
  4. Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly. Silver JT, et al. J Cell Biol, 2019 Oct 7. PMID 31409654, Free PMC Article
  5. Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease-linked MATR3 mutations in Drosophila. Zhao M, et al. FEBS Lett, 2020 Sep. PMID 32515490

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c19507273-19506668 mobile_element_type = transposon:Cr1a{}412

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitotic cytokinesis, division site positioning IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cleavage furrow rim IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysts
Names
CG10188-PA
CG10188-PB
CG10188-PC
cyst-PA
cyst-PB
cyst-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19502335..19508764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136133.5 → NP_609977.1  cysts, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIV0
    Related
    FBpp0080820
    Conserved Domains (3) summary
    cd15789
    Location:671 → 774
    PH_ARHGEF2_18_like; rho guanine nucleotide exchange factor
    pfam00169
    Location:681 → 774
    PH; PH domain
    pfam00621
    Location:447 → 627
    RhoGEF; RhoGEF domain

  2. NM_001273659.2 → NP_001260588.1  cysts, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBE1
    Conserved Domains (3) summary
    cd15789
    Location:671 → 774
    PH_ARHGEF2_18_like; rho guanine nucleotide exchange factor
    pfam00169
    Location:681 → 774
    PH; PH domain
    pfam00621
    Location:447 → 627
    RhoGEF; RhoGEF domain

  3. NM_165305.5 → NP_724203.2  cysts, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724203.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIV0
    Related
    FBpp0080821
    Conserved Domains (3) summary
    cd15789
    Location:671 → 774
    PH_ARHGEF2_18_like; rho guanine nucleotide exchange factor
    pfam00169
    Location:681 → 774
    PH; PH domain
    pfam00621
    Location:447 → 627
    RhoGEF; RhoGEF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBE1 M9PBE1
Q8MQR4 Q8MQR4
Q9VIV0 Q9VIV0

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