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APP amyloid beta (A4) precursor protein [ Homo sapiens (human) ]

Gene ID: 351, updated on 30-Jun-2015
Official Symbol
APPprovided by HGNC
Official Full Name
amyloid beta (A4) precursor proteinprovided by HGNC
Primary source
HGNC:HGNC:620
See related
Ensembl:ENSG00000142192; HPRD:00100; MIM:104760; Vega:OTTHUMG00000078438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma
Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Orthologs
Location:
21q21.3
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (25880550..26171128, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27252861..27543446, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372757 Neighboring gene uncharacterized LOC105372756 Neighboring gene myristoylated alanine-rich protein kinase C substrate pseudogene 1 Neighboring gene uncharacterized LOC105372811 Neighboring gene cysteine/tyrosine-rich 1 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Alzheimer's disease
MedGen: C0002395 OMIM: 104300 GeneReviews: Alzheimer Disease Overview
Compare labs
Cerebral amyloid angiopathy, APP-related
MedGen: C2751536 OMIM: 605714 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page
Triplosensitivity

Some evidence for dosage pathogenicity (Last evaluated (2012-07-06)

ClinGen Genome Curation PagePubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells PubMed
env Transgenic (tg) mice overexpressing both human amyloid precursor proteins and HIV-1 gp120 at moderate levels show significantly less neuronal loss, synapto-dendritic degeneration, and gliosis than singly tg mice expressing gp120 alone PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with amyloid beta (A4) precursor protein (APP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env A putative immunosuppressive domain (amino acids 583-599) of HIV-1 gp41 downregulates the interleukin 1beta- (IL-1beta) induced elevation of the secreted form of APP (sAPP alpha) PubMed
Tat tat HIV-1 Tat recruits APP into lipid rafts to facilitate the processing of APP by beta-secretase, which leads to increased levels of ABeta42 in HIV-1 infected U-87 MG cells PubMed
tat HIV-1 Tat co-localizes with APP and promotes localization of APP to lipid rafts with flotillin-1 in HIV-1 infected U-87 MG cells PubMed
tat Immunoprecipitation assay demonstrates that HIV-1 Tat directly interacts with APP and the cysteine-rich domain (residues 21-37) of Tat is required to APP binding in U-87 MG cells PubMed
tat HIV-1 Tat treatment results in a 125% increase in soluble amyloid beta (Abeta) in brain cultures PubMed
tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
retropepsin gag-pol HIV-1 protease cleaves amyloid protein precursor at amino acid sites 200-201, 229-230, and 535-536 PubMed

Go to the HIV-1, Human Interaction Database

  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, conserved biosystem (from KEGG)
    Streptomycin biosynthesis, conserved biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
PTB domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
acetylcholine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptidase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
axon cargo transport ISS
Inferred from Sequence or Structural Similarity
more info
 
axon midline choice point recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular copper ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
collateral sprouting in absence of injury ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix organization ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA polyadenylation ISS
Inferred from Sequence or Structural Similarity
more info
 
mating behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
Traceable Author Statement
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
regulation of synapse structure or activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
suckling behavior IEA
Inferred from Electronic Annotation
more info
 
synaptic growth at neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
ER to Golgi transport vesicle IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome lumen TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope lumen IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
spindle midzone IEA
Inferred from Electronic Annotation
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 
Preferred Names
amyloid beta A4 protein
Names
alzheimer disease amyloid protein
beta-amyloid peptide
beta-amyloid peptide(1-40)
beta-amyloid peptide(1-42)
cerebral vascular amyloid peptide
peptidase nexin-II
preA4
protease nexin-II

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007376.1 RefSeqGene

    Range
    4687..295272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000484.3NP_000475.1  amyloid beta A4 protein isoform a precursor

    See identical proteins and their annotated locations for NP_000475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as PreA4 770).
    Source sequence(s)
    AK312326, BC065529, BI559391, BM876312
    Consensus CDS
    CCDS13576.1
    UniProtKB/Swiss-Prot
    P05067
    Related
    ENSP00000284981, OTTHUMP00000096098, ENST00000346798, OTTHUMT00000171340
    Conserved Domains (7) summary
    pfam03494
    Location:672713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:715766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:365549
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001136016.3NP_001129488.1  amyloid beta A4 protein isoform d

    See identical proteins and their annotated locations for NP_001129488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AK295621, AK311717, BM876312, Y00264
    Consensus CDS
    CCDS56212.1
    UniProtKB/Swiss-Prot
    P05067
    Conserved Domains (7) summary
    pfam03494
    Location:648689
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:19183
    A4_EXTRA; amyloid A4
    pfam12924
    Location:127183
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:290337
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:25126
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:691742
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:341525
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001136129.2NP_001129601.1  amyloid beta A4 protein isoform e precursor

    See identical proteins and their annotated locations for NP_001129601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF282245, BC065529, BI559391, BM876312
    Consensus CDS
    CCDS46638.1
    UniProtKB/Swiss-Prot
    P05067
    Related
    ENSP00000346129, OTTHUMP00000096096, ENST00000354192, OTTHUMT00000171338
    Conserved Domains (5) summary
    pfam03494
    Location:541582
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam12924
    Location:76132
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam02177
    Location:1975
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:584635
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:234418
    APP_E2; E2 domain of amyloid precursor protein
  4. NM_001136130.2NP_001129602.1  amyloid beta A4 protein isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK294534, BC065523, BC065529, BI559391, BM876312
    Consensus CDS
    CCDS46639.1
    UniProtKB/TrEMBL
    B4DGD0
    UniProtKB/TrEMBL
    E9PG40
    UniProtKB/Swiss-Prot
    P05067
    Conserved Domains (6) summary
    pfam03494
    Location:616657
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam12924
    Location:76132
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:239286
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:1975
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:659710
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:309493
    APP_E2; E2 domain of amyloid precursor protein
  5. NM_001136131.2NP_001129603.1  amyloid beta A4 protein isoform g

    See identical proteins and their annotated locations for NP_001129603.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) is shorter at the N-terminus and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AK296229, BM876312, Y00264
    Consensus CDS
    CCDS56211.1
    UniProtKB/TrEMBL
    A0A0A0MRG2
    UniProtKB/TrEMBL
    B4DJT9
    UniProtKB/Swiss-Prot
    P05067
    Related
    ENSP00000352760, ENST00000359726
    Conserved Domains (6) summary
    pfam03494
    Location:562603
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:1153
    A4_EXTRA; amyloid A4
    pfam12924
    Location:97153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam02177
    Location:196
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:605656
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:255439
    APP_E2; E2 domain of amyloid precursor protein
  6. NM_001204301.1NP_001191230.1  amyloid beta A4 protein isoform h precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (h, also known as L-APP752) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
    Source sequence(s)
    AK294534, AK312326, BI559391, BM876312, Y00264
    Consensus CDS
    CCDS56213.1
    UniProtKB/TrEMBL
    B4DGD0
    UniProtKB/Swiss-Prot
    P05067
    Conserved Domains (7) summary
    pfam03494
    Location:654695
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:697748
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:365549
    APP_E2; E2 domain of amyloid precursor protein
  7. NM_001204302.1NP_001191231.1  amyloid beta A4 protein isoform i precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (i, also known as L-APP733) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
    Source sequence(s)
    BI559391, BM876312, X06989, Y00264
    UniProtKB/Swiss-Prot
    P05067
    Conserved Domains (7) summary
    pfam03494
    Location:635676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:678729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:346530
    APP_E2; E2 domain of amyloid precursor protein
  8. NM_001204303.1NP_001191232.1  amyloid beta A4 protein isoform j precursor

    See identical proteins and their annotated locations for NP_001191232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (j, also known as L-APP677) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
    Source sequence(s)
    BI559391, BM876312, Y00264
    UniProtKB/Swiss-Prot
    P05067
    Conserved Domains (6) summary
    pfam03494
    Location:579620
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:622673
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:290474
    APP_E2; E2 domain of amyloid precursor protein
  9. NM_201413.2NP_958816.1  amyloid beta A4 protein isoform b precursor

    See identical proteins and their annotated locations for NP_958816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as PreA4 751) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC065529, BI559391, BM876312
    Consensus CDS
    CCDS33523.1
    UniProtKB/Swiss-Prot
    P05067
    Related
    ENSP00000350578, OTTHUMP00000096095, ENST00000357903, OTTHUMT00000171337
    Conserved Domains (7) summary
    pfam03494
    Location:653694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:696747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:346530
    APP_E2; E2 domain of amyloid precursor protein
  10. NM_201414.2NP_958817.1  amyloid beta A4 protein isoform c precursor

    See identical proteins and their annotated locations for NP_958817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as PreA4 695) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BI559391, BM876312, Y00264
    Consensus CDS
    CCDS13577.1
    UniProtKB/Swiss-Prot
    P05067
    Related
    ENSP00000345463, OTTHUMP00000096097, ENST00000348990, OTTHUMT00000171339
    Conserved Domains (6) summary
    pfam03494
    Location:597638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:640691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:290474
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    25880550..26171128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    26813502..27104969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)