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    Arr1 Arrestin 1 [ Drosophila melanogaster ]

    Gene ID: 35078, updated on 10-May-2012
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    Summary

    Official Symbol
    Arr1provided by Flybase
    Official Full Name
    Arrestin 1provided by Flybase
    Primary source
    FLYBASE:FBgn0000120
    Locus tag
    Dmel_CG5711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3H10; Arr; arr1; ARR1; ArrA; CG5711; DA; DAI; DmArr1; Dmarrestin; Dmel\CG5711; Dro.-Arr.I; DS-Ag; FBgn0000120; PRII
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    Genomic context

    Location :
    36E3-36E3
    Sequence :
    Chromosome: 2L; NT_033779.4 (18078269..18081187)
    See Arr1 in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG31740 gene product from transcript CG31740-RA Neighboring gene CG15150 gene product from transcript CG15150-RB Neighboring gene reduced ocelli Neighboring gene neither inactivation nor afterpotential D Neighboring gene CG31741 gene product from transcript CG31741-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila. Mecklenburg KL, et al. J Neurosci, 2010 Jan 27. PMID 20107052.
    3. reduced ocelli encodes the leucine rich repeat protein Pray For Elves in Drosophila melanogaster. Caldwell JC, et al. Fly (Austin), 2007 May-Jun. PMID 18820435.
    4. Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III. Liu CH, et al. Neuron, 2008 Sep 11. PMID 18786361.
    5. Tandem affinity purification in Drosophila: the advantages of the GS-TAP system. Kyriakakis P, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719405.

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Arr1 mediates an endocytotic cell-survival activity, scavenging phosphorylated rhodopsin and thereby countering toxic Arr2/Rh1 accumulation.
      Title: Arrestin1 mediates light-dependent rhodopsin endocytosis and cell survival.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:61074 BioGRID:64400 Arr2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:61074 BioGRID:61276 CG10949    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:65701 CG11449    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:58732 CG11581    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:58157 CG12155    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:67678 CG13830    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:64715 CG17826    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:67097 CG3995    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:58789 CG5548    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:64643 CG6175    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:66394 CG6254    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:58903 CG8924    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:63093 Rae1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:61074 BioGRID:78043 RpL15    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:68312 dgt6    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:58076 dx    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:62028 en    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:68588 sip3    BioGRID  PubMed Two-hybrid 
    BioGRID:61074 BioGRID:71315 ttk    BioGRID  PubMed Two-hybrid 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    metarhodopsin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    metarhodopsin binding TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    deactivation of rhodopsin mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    deactivation of rhodopsin mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    metarhodopsin inactivation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    metarhodopsin inactivation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    phototransduction NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG5711 gene product from transcript CG5711-RB
    Names
    Arr1-PA
    Arr1-PB
    CG5711-PA
    CG5711-PB
    Phosrestin-II
    arrestin
    arrestin 1
    arrestin A
    arrestin1
    drosophila arrestin
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      18078269..18081187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259144.1 → NP_001246073.1  arrestin 1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_057333.4 → NP_476681.1  arrestin 1, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15372
      Related
      FBpp0080583
      Conserved Domains (1) summary
      cl02844
      Location:17 – 173
      Blast Score: 240
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 AFH03747.1
    genomic M30140.1 AAA28380.1
    genomic AE014134.5 AAF53644.1
    mRNA AY061824.1 AAL27635.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    A34867.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content