lace [Drosophila melanogaster] - Gene

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Summary

Official Symbol: laceprovided by Flybase
Primary source: FLYBASE:FBgn0002524
Locus tag: Dmel_CG4162
Gene type: protein coding
RNA name: lace
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey289; BG:DS01845.3; br36; CG4162; Dmel\CG4162; l(2)35Dc; l(2)br36; l35Dc; Lace; SPT-II

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Genomic context

Location :: 35D2-35D2

Sequence :: Chromosome: 2L; NT_033779.4 (15499110..15505018)

See lace in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:60925	BioGRID:57994	CG32758	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:66993	CG4287	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:67481	CG5802	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:67017	CG6126	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:61052	CG6453	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:68262	CG9986	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:60925	BioGRID:66904	Hsc70-4	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:61819	RpL31	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:63196	RpS16	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:60502	RpS27A	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:70079	Sply	BioGRID	PubMed	Phenotypic Suppression
BioGRID:60925	BioGRID:62215	Spt-I	BioGRID	PubMed	Affinity Capture-MS
BioGRID:60925	BioGRID:67333	Vha13	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:62254	cid	BioGRID	PubMed	Two-hybrid
BioGRID:60925	BioGRID:57954	dhd	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the lace gene: The lace gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.

Pathways from BioSystems

Ceramide biosynthesis, organism-specific biosystem (from KEGG)
Ceramide biosynthesis, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Ceramide biosynthesis, conserved biosystem (from KEGG)
Ceramide biosynthesis, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sphingolipid de novo biosynthesis, organism-specific biosystem (from REACTOME)
Sphingolipid de novo biosynthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sphingolipid metabolism, organism-specific biosystem (from KEGG)
Sphingolipid metabolism, organism-specific biosystem
Sphingolipid metabolism
Sphingolipid metabolism, organism-specific biosystem (from REACTOME)
Sphingolipid metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sphingolipid metabolism, conserved biosystem (from KEGG)
Sphingolipid metabolism, conserved biosystem
Sphingolipid metabolism
Sphingosine biosynthesis, organism-specific biosystem (from KEGG)
Sphingosine biosynthesis, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Sphingosine biosynthesis, conserved biosystem (from KEGG)
Sphingosine biosynthesis, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
contributes_to serine C-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
serine C-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
serine C-palmitoyltransferase activity	NAS Non-traceable Author Statement more info
transferase activity, transferring nitrogenous groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG4162 gene product from transcript CG4162-RA

Names: CG4162-PA; lace; lace-PA; serine palmitoyltransferase subunit II

NP_476614.1

EC 2.3.1.50

EC 2.6.-.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

15499110..15505018

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057266.4 → NP_476614.1 lace [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3F2

Related

FBpp0080297, FBtr0080738

Conserved Domains (2) summary

COG0156
Location:164 – 577
Blast Score: 739

BioF; 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]

cl00321
Location:214 – 577
Blast Score: 943

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...