Display Settings:

Format

Send to:

Choose Destination

IGFBP5 insulin-like growth factor binding protein 5 [ Homo sapiens (human) ]

Gene ID: 3488, updated on 13-Jan-2015
Official Symbol
IGFBP5provided by HGNC
Official Full Name
insulin-like growth factor binding protein 5provided by HGNC
Primary source
HGNC:HGNC:5474
See related
Ensembl:ENSG00000115461; HPRD:00901; MIM:146734; Vega:OTTHUMG00000133058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP5
Orthologs
See IGFBP5 in MapViewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (216672105..216695549, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217536828..217560272, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type, 3 pseudogene 2 Neighboring gene insulin-like growth factor binding protein 2, 36kDa Neighboring gene ribosomal protein L31 pseudogene 14 Neighboring gene RNA, 5S ribosomal pseudogene 120

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor I binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
mammary gland involution IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle tissue growth IEA
Inferred from Electronic Annotation
more info
 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor binding protein complex IC
Inferred by Curator
more info
PubMed 
Preferred Names
insulin-like growth factor-binding protein 5
Names
insulin-like growth factor-binding protein 5
IBP-5
IGFBP-5
IGF-binding protein 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000599.3NP_000590.1  insulin-like growth factor-binding protein 5 precursor

    See proteins identical to NP_000590.1

    Status: VALIDATED

    Source sequence(s)
    AC007563, AF055033, BC032366, DA691367
    Consensus CDS
    CCDS2405.1
    UniProtKB/TrEMBL
    A0A024R433
    UniProtKB/Swiss-Prot
    P24593
    Related
    ENSP00000233813, OTTHUMP00000164060, ENST00000233813, OTTHUMT00000256674
    Conserved Domains (2) summary
    smart00121
    Location:25101
    IB; Insulin growth factor-binding protein homologues
    cd00191
    Location:191263
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    216672105..216695549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    217543006..217566425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    209391205..209414636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)