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    IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]

    Gene ID: 3480, updated on 20-May-2012
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    Summary

    Official Symbol
    IGF1Rprovided by HGNC
    Official Full Name
    insulin-like growth factor 1 receptorprovided by HGNC
    Primary source
    HGNC:5465
    See related
    Ensembl:ENSG00000140443; HPRD:00932; MIM:147370; Vega:OTTHUMG00000149851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172
    Summary
    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    15q26.3
    Sequence :
    Chromosome: 15; NC_000015.9 (99192761..99507759)
    See IGF1R in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene arrestin domain containing 4 Neighboring gene zinc finger, CCHC domain containing 9 pseudogene Neighboring gene family with sequence similarity 169, member B Neighboring gene microRNA 4714 Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene synemin, intermediate filament protein

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma. Pengchong H, et al. Eur J Gynaecol Oncol, 2011. PMID 22335030.
    2. Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients. Lunetta C, et al. Muscle Nerve, 2012 Feb. PMID 22246875.
    3. Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model. Durfort T, et al. PLoS One, 2012. PMID 22235273.
    4. Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling. Li S, et al. Cancer Res, 2012 Feb 15. PMID 22194466.
    5. [Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature]. Huang H, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2011 Dec. PMID 22172258.

    See all (506) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. activating mutation of PIK3CA, loss of PTEN, or IGF1R expression have a role in round cell transformation
      Title: Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma.
    2. short interfering RNA (siRNAs) for inhibition of in vivo tumor growth and immunological stimulation in immunocompetent mice
      Title: Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.
    3. our findings define an IGF-IR-mediated mechanism of cancer cell survival that is critical for metastatic colonization of the liver.
      Title: Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.
    4. Data show that inhibitors of Stat3, IGF-IR and Rho GTPase were the most promising therapeutic agents for ovarian cancer.
      Title: Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets.
    5. Results suggest that EGR-1 may stimulate prostate cancer cell growth through up-regulation of IGF-1R and indicate that down-regulation of EGR-1 could be an effective therapeutic approach against prostate cancer.
      Title: Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells.
    6. The p.E121K/E234K variant is the cause of intrauterine growth retardation and the most severe postnatal growth failure described to date in a patient with IGF1R defects.
      Title: Severe short stature caused by novel compound heterozygous mutations of the insulin-like growth factor 1 receptor (IGF1R).
    7. This study has therefore lead to a greater understanding of the mechanisms of IGF-II binding and activation of the IGF-1R and IR-A.
      Title: Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.
    8. IGF-1R is an independent prognostic marker for osteosarcoma patients and increased expression of this molecular is correlated with metastasis of osteosarcoma.
      Title: Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma.
    9. Functional experiments showed that LL-37-dependent activation of the IGF-1 receptor signaling resulted in increased migratory and invasive potential of malignant cells.
      Title: Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.
    10. IGF-IR might identify a subset of biliary tract carcinomas with a particularly aggressive phenotype and is a candidate therapeutic target in this disease.
      Title: Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.
    Submit: New GeneRIF Correction See all (357)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Hundreds of variants clustered in genomic loci and biological pathways affect human height.

    Insulin-like growth factor I, resistance to

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000866.1 NP_004374.1 CSK    BIND  PubMed CSK interacts with IGF-IR. 
    NP_000866.1 NP_006786.2 EHD1    BIND  PubMed EHD1 interacts with IGF-1R. 
    NP_000866.1 NP_006089.1 GNB2L1    BIND  PubMed IGF-IR interacts with RACK1. 
    NP_000866.1 NP_001001550.1 GRB10    BIND  PubMed Grb10 interacts with IGFIR. 
    NP_000866.1 NP_005535.1 IRS1    BIND  PubMed IGFIR interacts with IRS-1. 
    NP_000866.1 NP_005535.1 IRS1    BIND  PubMed IRS-1 interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IGF-IR. 
    NP_000866.1 NP_003740.1 IRS2    BIND  PubMed Insulin Receptor Substrate-2 Binds to the Insulin-like Growth Factor Receptor Beta subunit. This interaction is modeled on demonstrated interaction between human IGF-IR and murine IRS-2 
    NP_000866.1 ITGB1    BIND  PubMed beta-1 integrin interacts with IGF-IR. 
    NP_000866.1 NP_002218.1 JAK1    BIND  PubMed Phosphorylated IGF-1R-beta interacts with JAK-1. 
    NP_000866.1 NP_005018.1 PIK3R2    BIND  PubMed IGFIR interacts with p85. This interaction was modeled on a demonstrated interaction between rat proteins. 
    NP_000866.1 NP_006245.2 PRKCD    BIND  PubMed PKC-delta interacts with IGF-IR. 
    NP_000866.1 NP_002733.1 PRKD1    BIND  PubMed PKC-mu interacts with IGF-IR. 
    NP_000866.1 NP_003020.2 SHC1    BIND  PubMed IGFIR interacts with SHC. 
    NP_000866.1 NP_003736.1 SOCS1    BIND  PubMed Insulin-like Growth Factor-I Receptor interacts with SOCS1 
    NP_000866.1 NP_003868.1 SOCS2    BIND  PubMed Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor 
    NP_000866.1 NP_003946.3 SOCS3    BIND  PubMed Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor I receptor. 
    NP_000866.1 NP_003395.1 YWHAB    BIND  PubMed IGFIR interacts with 14-3-3-beta isoform. This interaction was modelled on a demonstrated interaction between human IGFIR and mouse 14-3-3-beta. 
    NP_000866.1 NP_006752.1 YWHAE    BIND  PubMed IGFIR interacts with 14-3-3-epsilon isoform. This interaction is modeled on a demonstrated interaction between human IGFIR and mouse 14-3-3-epsilon isoform 
    NP_000866.1 NP_003397.1 YWHAZ    BIND  PubMed IGFIR interacts with 14-3-3-zeta isoform. 
    P08069 Q9NZN5 ARHGEF12    HPRD  PubMed  
    P08069 P46108 CRK    HPRD  PubMed  
    P08069 P46109 CRKL    HPRD  PubMed  
    P08069 P41240 CSK    HPRD  PubMed  
    P08069 Q8TEW6 DOK4    HPRD  PubMed  
    P08069 Q9P104 DOK5    HPRD  PubMed  
    P08069 Q9H4M9 EHD1    HPRD  PubMed  
    P08069 P03372 ESR1    HPRD  PubMed  
    P08069 O14908 GIPC1    HPRD  PubMed  
    P08069 P63096 GNAI1    HPRD  PubMed  
    P08069 P04899 GNAI2    HPRD  PubMed  
    P08069 P63244 GNB2L1    HPRD  PubMed  
    P08069 Q13322 GRB10    HPRD  PubMed  
    P08069 P05019 IGF1    HPRD  PubMed  
    P08069 P08069 IGF1R    HPRD  PubMed  
    P08069 P01344 IGF2    HPRD  PubMed  
    P08069 P17936 IGFBP3    HPRD  PubMed  
    P08069 P01308 INS    HPRD  PubMed  
    P08069 P06213 INSR    HPRD  PubMed  
    P08069 P35568 IRS1    HPRD  PubMed  
    P08069 Q9Y4H2 IRS2    HPRD  PubMed  
    P08069 Insulin receptor substrate 4 IRS4    HPRD  PubMed  
    P08069 P05556 ITGB1    HPRD  PubMed  
    P08069 P23458 JAK1    HPRD  PubMed  
    P08069 O60674 JAK2    HPRD  PubMed  
    P08069 Q9UEF7 KL    HPRD  PubMed  
    P08069 Keratin 25C KRT27    HPRD  PubMed  
    P08069 Q99683 MAP3K5    HPRD  PubMed  
    P08069 Q00987 MDM2    HPRD  PubMed  
    P08069 P46934 NEDD4    HPRD  PubMed  
    P08069 P27986 PIK3R1    HPRD  PubMed  
    P08069 O00459 PIK3R2    HPRD  PubMed  
    P08069 Q92569 PIK3R3    HPRD  PubMed  
    P08069 Q05655 PRKCD    HPRD  PubMed  
    P08069 Q15139 PRKD1    HPRD  PubMed  
    P08069 P18031 PTPN1    HPRD  PubMed  
    P08069 Q06124 PTPN11    HPRD  PubMed  
    P08069 P20936 RASA1    HPRD  PubMed  
    P08069 O15524 SOCS1    HPRD  PubMed  
    P08069 O14508 SOCS2    HPRD  PubMed  
    P08069 O14543 SOCS3    HPRD  PubMed  
    P08069 P12931 SRC    HPRD  PubMed  
    P08069 P40763 STAT3    HPRD  PubMed  
    P08069 Q9UKW4 VAV3    HPRD  PubMed  
    P08069 O76076 WISP2    HPRD  PubMed  
    P08069 P31946 YWHAB    HPRD  PubMed  
    P08069 P62258 YWHAE    HPRD  PubMed  
    P08069 P61981 YWHAG    HPRD  PubMed  
    P08069 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:109701 BioGRID:116945 ARHGEF12    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109701 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:247425 Arrb1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:107270 CAMP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109701 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109701 BioGRID:107832 CSK    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109701 BioGRID:113999 EEA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:116138 EHD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109701 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:109032 GNAI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:109144 GRB10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109701 BioGRID:109700 IGF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109701 BioGRID:109707 IGFBP3    BioGRID  PubMed Co-purification 
    BioGRID:109701 BioGRID:109874 IRS1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109701 BioGRID:109919 JAK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109701 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109701 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109701 BioGRID:114075 PIK3R3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109701 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:111736 PTPN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109701 BioGRID:111787 PXN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:111856 RASA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109701 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109701 BioGRID:114748 SNAP29    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:114203 SOCS1    BioGRID  PubMed Two-hybrid 
    BioGRID:109701 BioGRID:114362 SOCS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109701 BioGRID:114488 SOCS3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109701 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109701 BioGRID:115715 VAV3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109701 BioGRID:113361 YWHAB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109701 BioGRID:113363 YWHAE    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109701 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
      Endochondral Ossification, organism-specific biosystem
      Endochondral Ossification
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • IGF1 pathway, organism-specific biosystem (from Pathway Interaction Database)
      IGF1 pathway, organism-specific biosystem
      IGF1 pathway
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Plasma membrane estrogen receptor signaling, organism-specific biosystem
      Plasma membrane estrogen receptor signaling
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    insulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    insulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    insulin-like growth factor I binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    insulin-like growth factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insulin-like growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol 3-kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    exocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    inactivation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insulin-like growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    male sex determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    mammary gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein kinase B signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol 3-kinase cascade IC
    Inferred by Curator
    more info
    		 PubMed 
    phosphatidylinositol-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of anti-apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein kinase B signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of steroid hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    prostate gland epithelium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to vitamin E IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microsome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    insulin-like growth factor 1 receptor
    Names
    insulin-like growth factor 1 receptor
    IGF-I receptor
    soluble IGF1R variant 1
    soluble IGF1R variant 2
    insulin-like growth factor I receptor
    NP_000866.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009492.1 RefSeqGene

      Range
      5001..319999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000875.3 → NP_000866.1  insulin-like growth factor 1 receptor precursor

      Status: REVIEWED

      Source sequence(s)
      AC069029, BC113610, BM264223, BQ185364, BX093045, CN414655, DA486252, DR007209, X04434
      Consensus CDS
      CCDS10378.1
      UniProtKB/Swiss-Prot
      P08069
      Related
      ENSP00000268035, OTTHUMP00000194784, ENST00000268035, OTTHUMT00000313537
      Conserved Domains (7) summary
      cd00063
      Location:835 – 924
      Blast Score: 121
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:230 – 277
      Blast Score: 129
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05062
      Location:992 – 1268
      Blast Score: 1526
      PTKc_IGF-1R; Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor
      pfam00757
      Location:175 – 333
      Blast Score: 551
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:51 – 161
      Blast Score: 328
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:999 – 1266
      Blast Score: 1090
      Pkinase_Tyr; Protein tyrosine kinase
      cl00065
      Location:492 – 585
      Blast Score: 101
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      99192761..99507759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      75320348..75635223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152452.1: Suppressed sequence

      Description
      NM_152452.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC055807.11 (21441..178200) None
    genomic AC069029.9 (21277..25938) None
    genomic AC118658.4 (152383..168726) None
    genomic AC118660.5 (125299..167850) None
    genomic AY332722.1 AAP81165.1
    genomic CH471101.1 EAX02220.1
      EAX02221.1
      EAX02222.1
    genomic CS238517.1 CAJ55819.1
    genomic M69229.1 AAB59399.1
    mRNA AB425196.1 BAG11657.1
    mRNA AF020763.1 AAB97676.1
    mRNA AK310188.1 None
    mRNA AY429545.1 None
    mRNA BC010607.1 None
    mRNA BC078157.1 None
    mRNA BC088377.1 None
    mRNA BC107089.1 AAI07090.1
    mRNA BC111046.1 None
    mRNA BC113610.1 AAI13611.1
    mRNA BC113612.1 AAI13613.1
    mRNA BC143721.1 AAI43722.1
    mRNA BM264223.1 None
    mRNA BQ185364.1 None
    mRNA BX093045.1 None
    mRNA CN414655.1 None
    mRNA DA486252.1 None
    mRNA DR007209.1 None
    mRNA EU826611.1 ACF47647.1
    mRNA EU826612.1 ACF47648.1
    mRNA X04434.1 CAA28030.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43467 GenPept UniProtKB/TrEMBL:O43467
    P08069.1 GenPept UniProtKB/Swiss-Prot:P08069
    Q3B833 GenPept UniProtKB/TrEMBL:Q3B833
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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