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APOE apolipoprotein E [ Homo sapiens (human) ]

Gene ID: 348, updated on 17-Apr-2014
Official Symbol
APOEprovided by HGNC
Official Full Name
apolipoprotein Eprovided by HGNC
Primary source
HGNC:613
See related
Ensembl:ENSG00000130203; HPRD:00135; MIM:107741; Vega:OTTHUMG00000128901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD2; LPG; LDLCQ5
Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]
Location :
19q13.2
Sequence :
Chromosome: 19; NC_000019.10 (44905782..44909393)
See APOE in Epigenomics, MapViewer

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene poliovirus receptor-related 2 (herpesvirus entry mediator B) Neighboring gene translocase of outer mitochondrial membrane 40 homolog (yeast) Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein C-I pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Age-related macular degeneration 1
MedGen: C1864205 OMIM: 603075 GeneReviews: Not available
Compare labs
Alzheimer disease, type 2
MedGen: C1863051 OMIM: 104310 GeneReviews: Not available
Compare labs
Alzheimer disease, type 4 Compare labs
Lipoprotein glomerulopathy
MedGen: C2673196 OMIM: 611771 GeneReviews: Not available
Compare labs
Sea-blue histiocyte syndrome
MedGen: C0036489 OMIM: 269600 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
NHGRI GWA Catalog
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
NHGRI GWA Catalog
A genome-wide scan for common variants affecting the rate of age-related cognitive decline.
NHGRI GWA Catalog
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
NHGRI GWA Catalog
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
NHGRI GWA Catalog
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
NHGRI GWA Catalog
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
NHGRI GWA Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
NHGRI GWA Catalog
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
NHGRI GWA Catalog
Examination of the current top candidate genes for AD in a genome-wide association study.
NHGRI GWA Catalog
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
NHGRI GWA Catalog
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
NHGRI GWA Catalog
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
NHGRI GWA Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
NHGRI GWA Catalog
Genome-wide analysis of genetic loci associated with Alzheimer disease.
NHGRI GWA Catalog
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
NHGRI GWA Catalog
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association study of Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
NHGRI GWA Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
NHGRI GWA Catalog
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
NHGRI GWA Catalog
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
NHGRI GWA Catalog
High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.
NHGRI GWA Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
NHGRI GWA Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
NHGRI GWA Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
NHGRI GWA Catalog
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
NHGRI GWA Catalog
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
NHGRI GWA Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
NHGRI GWA Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
NHGRI GWA Catalog
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
NHGRI GWA Catalog
Seven new loci associated with age-related macular degeneration.
NHGRI GWA Catalog
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
NHGRI GWA Catalog
Sorl1 as an Alzheimer's disease predisposition gene?
NHGRI GWA Catalog
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
NHGRI GWA Catalog
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes increased neurotoxicity in human neuronal cultures with the ApoE4 allele PubMed
Tat, p14 tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
tat The antioxidant properties of human lipidated apoE3 protects neurons from Tat-induced toxicity PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Chylomicron-mediated lipid transport, organism-specific biosystem (from REACTOME)
    Chylomicron-mediated lipid transport, organism-specific biosystemChylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single mole...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with visual transduction, organism-specific biosystem (from REACTOME)
    Diseases associated with visual transduction, organism-specific biosystemThe process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defect...
  • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
    HDL-mediated lipid transport, organism-specific biosystemHDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and e...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
    Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Retinoid metabolism and transport, organism-specific biosystem (from REACTOME)
    Retinoid metabolism and transport, organism-specific biosystemVitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptox...
  • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Statin Pathway, organism-specific biosystem (from WikiPathways)
    Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...
  • Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin B12 Metabolism, organism-specific biosystem
    Vitamin B12 Metabolism
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
beta-amyloid binding IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol transporter activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
hydroxyapatite binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
 
low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal chelating activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine-sterol O-acyltransferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
very-low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
N-methyl-D-aspartate receptor clustering IDA
Inferred from Direct Assay
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering IDA
Inferred from Direct Assay
more info
 
artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell death IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to cholesterol IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
chylomicron remnant clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
dendritic spine maintenance IDA
Inferred from Direct Assay
more info
 
fatty acid homeostasis IDA
Inferred from Direct Assay
more info
 
fibril organization IDA
Inferred from Direct Assay
more info
 
high-density lipoprotein particle assembly IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular transport TAS
Traceable Author Statement
more info
PubMed 
lipoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipoprotein metabolic process TAS
Traceable Author Statement
more info
 
long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
 
low-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 
maintenance of location in cell IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of beta-amyloid formation IDA
Inferred from Direct Assay
more info
 
negative regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of postsynaptic membrane organization IDA
Inferred from Direct Assay
more info
 
negative regulation of presynaptic membrane organization IDA
Inferred from Direct Assay
more info
 
nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system axon regeneration IEA
Inferred from Electronic Annotation
more info
 
phospholipid efflux IDA
Inferred from Direct Assay
more info
PubMed 
phototransduction, visible light TAS
Traceable Author Statement
more info
 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of beta-amyloid formation IDA
Inferred from Direct Assay
more info
 
positive regulation of cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cholesterol esterification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
 
positive regulation of low-density lipoprotein particle receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron death IDA
Inferred from Direct Assay
more info
 
positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Cdc42 protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axon extension TAS
Traceable Author Statement
more info
PubMed 
regulation of neuron death IDA
Inferred from Direct Assay
more info
 
regulation of neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 
response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to reactive oxygen species NAS
Non-traceable Author Statement
more info
PubMed 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
reverse cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
synaptic transmission, cholinergic TAS
Traceable Author Statement
more info
PubMed 
triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasodilation IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
very-low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
blood microparticle IDA
Inferred from Direct Assay
more info
 
chylomicron IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
dendrite NAS
Non-traceable Author Statement
more info
PubMed 
early endosome TAS
Traceable Author Statement
more info
 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
intermediate-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
apolipoprotein E
Names
apolipoprotein E
apo-E
apolipoprotein E3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007084.2 RefSeqGene

    Range
    5001..8612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000041.2NP_000032.1  apolipoprotein E precursor

    See proteins identical to NP_000032.1

    Status: REVIEWED

    Source sequence(s)
    BC003557, BU848796
    Consensus CDS
    CCDS12647.1
    UniProtKB/Swiss-Prot
    P02649
    Related
    ENSP00000252486, OTTHUMP00000159143, ENST00000252486, OTTHUMT00000250865
    Conserved Domains (1) summary
    pfam01442
    Location:104299
    Blast Score: 307
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10

    Range
    44905782..44909393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258867.1XP_005258924.1  

    Conserved Domains (1) summary
    pfam01442
    Location:130325
    Blast Score: 329
    Apolipoprotein; Apolipoprotein A1/A4/E domain

Alternate HuRef

Genomic

  1. AC_000151.1 Alternate HuRef

    Range
    41839825..41843436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    45411793..45415404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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