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    TUBB2B tubulin, beta 2B class IIb [ Homo sapiens ]

    Gene ID: 347733, updated on 12-May-2012
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    Summary

    Official Symbol
    TUBB2Bprovided by HGNC
    Official Full Name
    tubulin, beta 2B class IIbprovided by HGNC
    Primary source
    HGNC:30829
    Locus tag
    RP11-506K6.1
    See related
    Ensembl:ENSG00000137285; HPRD:14707; MIM:612850; Vega:OTTHUMG00000014143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bA506K6.1; MGC8685; RP11-506K6.1; FLJ98847; DKFZp566F223
    Summary
    The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
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    Genomic context

    Location :
    6p25
    Sequence :
    Chromosome: 6; NC_000006.11 (3224495..3227968, complement)
    See TUBB2B in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene tubulin, beta 2B pseudogene Neighboring gene uncharacterized LOC100507194 Neighboring gene uncharacterized LOC100507294 Neighboring gene solute carrier family 22, member 23 Neighboring gene proteasome (prosome, macropain) assembly chaperone 4 Neighboring gene uncharacterized LOC643327

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Kahle JJ, et al. Hum Mol Genet, 2011 Feb 1. PMID 21078624.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TUBB2B is required for neuronal migration two disease-associated mutations lead to impaired formation of tubulin heterodimers.
      Title: Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.
    2. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl.
      Title: Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.
    3. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
      Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
    4. The data suggest that the ratio of beta-tubulin classes II and V mRNA could be useful as a biomarker for NSCLC tumor differentiation and/or NSCLC aggressiveness.
      Title: Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas.
    5. The class II beta-tubulin isotype seems to be a promising predictive marker of docetaxel activity in the treatment of breast neoplasms.
      Title: Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study.
    Submit: New GeneRIF Correction
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Polymicrogyria, asymmetric

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:131483 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:107106 BID    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:122420 C8orf33    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:107227 CACNA1A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:131483 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:107843 CSNK2B    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:131483 BioGRID:110357 MDK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:131483 BioGRID:122805 MLF1IP    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:111929 RGS2    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:116392 RPL35    BioGRID  PubMed Two-hybrid 
    BioGRID:131483 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the TUBB2B gene: The TUBB2B gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
      Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
    • Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, organism-specific biosystem (from REACTOME)
      Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, organism-specific biosystemIn the case of actin and tubulin folding, and perhaps other substrates, the emerging polypeptide chain is transferred from the ribosome to TRiC via Prefoldin (Vainberg et al., 1998).
    • Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystem (from REACTOME)
      Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystemTriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Fiv...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Post-chaperonin tubulin folding pathway, organism-specific biosystem (from REACTOME)
      Post-chaperonin tubulin folding pathway, organism-specific biosystemAlpha and beta tubulin folding intermediates are formed through ATPâ??dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of...
    • Prefoldin mediated transfer of substrate to CCT/TriC, organism-specific biosystem (from REACTOME)
      Prefoldin mediated transfer of substrate to CCT/TriC, organism-specific biosystemUnfolded actins and tubulins bound to prefoldin are transferred to CCT via a docking mechanism (McCormack and Willison, 2001).
    • Protein folding, organism-specific biosystem (from REACTOME)
      Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    'de novo' posttranslational protein folding TAS
    Traceable Author Statement
    more info
    		  
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
    		  
    microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein folding TAS
    Traceable Author Statement
    more info
    		  
    protein polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    tubulin beta-2B chain
    Names
    tubulin beta-2B chain
    class IIb beta-tubulin
    class II beta-tubulin isotype
    tubulin, beta polypeptide paralog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016715.1 RefSeqGene

      Range
      5001..8474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178012.4 → NP_821080.1  tubulin beta-2B chain

      Status: REVIEWED

      Source sequence(s)
      BC001352, BC063610, BG056085, BX419454
      Consensus CDS
      CCDS4485.1
      UniProtKB/Swiss-Prot
      Q9BVA1
      Related
      ENSP00000259818, OTTHUMP00000015964, ENST00000259818, OTTHUMT00000039680
      Conserved Domains (2) summary
      cd02187
      Location:2 – 426
      Blast Score: 2451
      beta_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of ...
      PLN00220
      Location:1 – 430
      Blast Score: 2371
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      3224495..3227968, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      3102307..3105779, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL445309.13 CAI40952.1
    genomic CH471087.1 EAW55125.1
      EAW55126.1
      EAW55127.1
      EAW55128.1
    mRNA AF035316.1 AAB88188.1
    mRNA AK289433.1 BAF82122.1
    mRNA AK297568.1 BAH12617.1
    mRNA AK308806.1 None
    mRNA AL050056.1 CAB43252.1
    mRNA BC001352.2 AAH01352.1
    mRNA BC063610.1 AAH63610.1
    mRNA BC127872.1 AAI27873.2
    mRNA BC127874.1 AAI27875.1
    mRNA BG056085.1 None
    mRNA BT019930.1 AAV38733.1
    mRNA BX419454.2 None
    mRNA CR456788.1 CAG33069.1
    other-genetic HQ447903.1 ADQ32387.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43209 GenPept UniProtKB/TrEMBL:O43209
    Q9BVA1.1 GenPept UniProtKB/Swiss-Prot:Q9BVA1
    Q9UGA2 GenPept UniProtKB/TrEMBL:Q9UGA2
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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