kuz kuzbanian [Drosophila melanogaster] - Gene

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Summary

Official Symbol: kuzprovided by Flybase
Official Full Name: kuzbanianprovided by Flybase
Primary source: FLYBASE:FBgn0259984
Locus tag: Dmel_CG7147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11410; 34Da; ADAM10; BG:DS07660.3; br38; CG7147; CT22079; Dmel\CG7147; GS11410; Kuz; l(2)03782; l(2)34Da; l(2)br38; l(2)c00136; l(2)k01403; l34Da

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Genomic context

Location :: 34C4-34C6

Sequence :: Chromosome: 2L; NT_033779.4 (13550141..13638238)

See kuz in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

indicates that KUZ is required to facilitate a functional Notch signal in the Notch-dependent cell for correct cell fate specification
Title: On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages.
Kuz regulates Notch signaling primarily by activating the Notch receptor and has little overall effect on signaling via disabling Delta.
Title: Kuz and TACE can activate Notch independent of ligand.
clonal analysis of kuz in Drosophila wing
Title: kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing.
KUZ regulates the relay between the G protein-coupled receptors and EGF ereceptors signaling pathways
Title: The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors.
Kuzbanian acts during lateral inhibition within the cardiac primordium. Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis.
Title: The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.
Notch activation and KUZ expression are restricted to border cells at stage 9 of oogenesis
Title: Spatially localized Kuzbanian required for specific activation of Notch during border cell migration.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:60806	BioGRID:68061	E(spl)	BioGRID	PubMed	Phenotypic Suppression
BioGRID:60806	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Suppression
BioGRID:60806	BioGRID:57823	N	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:60806	BioGRID:68163	Ser	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:60806	BioGRID:63919	sty	BioGRID	PubMed	Two-hybrid

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General gene information

Markers

Dm0698 (e-PCR)
- UniSTS:56256

Homology

Homologs of the kuz gene: The kuz gene is conserved in zebrafish, mosquito, and C.elegans.

Pathways from BioSystems

Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH, organism-specific biosystem (from REACTOME)
Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH2, organism-specific biosystem (from REACTOME)
Signaling by NOTCH2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH3, organism-specific biosystem (from REACTOME)
Signaling by NOTCH3, organism-specific biosystemcomputationally inferred pathway (not manually curated)

mobile_element

Loc: 13560515-13565210 mobile_element_type = transposon:F{}kuz[F363]
Loc: 13611261-13611320 mobile_element_type = transposon:INE-1{}2292

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
metalloendopeptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Notch receptor processing	IGI Inferred from Genetic Interaction more info	PubMed
Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info
border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
cardiac cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
central nervous system development	TAS Traceable Author Statement more info	PubMed
glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
proteolysis	IEA Inferred from Electronic Annotation more info
regulation of Roundabout signaling pathway	IGI Inferred from Genetic Interaction more info
regulation of axon extension	TAS Traceable Author Statement more info	PubMed
skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

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General protein information

Preferred Names: CG7147 gene product from transcript CG7147-RA

Names: CG7147-PA; CG7147-PB; CG7147-PC; CG7147-PD; CG7147-PF; kuz-PA; kuz-PB; kuz-PC; kuz-PD; kuz-PF; kuzbanian; kuzbaninan; lethal (2) c00136

NP_001014481.1

EC 3.4.24.-

NP_001097159.1

EC 3.4.24.-

NP_001097160.2

EC 3.4.24.-

NP_477187.1

EC 3.4.24.-

NP_723825.1

EC 3.4.24.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

13550141..13638238

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057839.4 → NP_477187.1 kuzbanian, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VJW9

Related

FBpp0080087, FBtr0080509

Conserved Domains (3) summary

cd04270
Location:410 – 677
Blast Score: 775

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:51 – 149
Blast Score: 115

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:684 – 778
Blast Score: 188

Disintegrin; Disintegrin
NM_001103689.1 → NP_001097159.1 kuzbanian, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A8DZ03

Related

FBpp0111799, FBtr0112886

Conserved Domains (3) summary

cd04270
Location:428 – 695
Blast Score: 775

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:69 – 167
Blast Score: 115

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:702 – 796
Blast Score: 187

Disintegrin; Disintegrin
NM_165047.2 → NP_723825.1 kuzbanian, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VJW9

Related

FBpp0080088, FBtr0080510

Conserved Domains (3) summary

cd04270
Location:410 – 677
Blast Score: 775

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:51 – 149
Blast Score: 115

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:684 – 778
Blast Score: 188

Disintegrin; Disintegrin
NM_001103690.2 → NP_001097160.2 kuzbanian, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A8DZ02

Related

FBpp0290626, FBtr0301412

Conserved Domains (3) summary

cd04270
Location:410 – 677
Blast Score: 775

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:51 – 149
Blast Score: 115

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:684 – 778
Blast Score: 189

Disintegrin; Disintegrin
NM_001014481.2 → NP_001014481.1 kuzbanian, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q59DZ3

Related

FBpp0100122, FBtr0100660

Conserved Domains (3) summary

cd04270
Location:410 – 677
Blast Score: 772

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:51 – 149
Blast Score: 115

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:684 – 778
Blast Score: 186

Disintegrin; Disintegrin

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014134.5	AAN10838.1
genomic	AE014134.5	AAF53318.1
genomic	AE014134.5	ABV53679.1
genomic	AE014134.5	ABV53680.2
genomic	AE014134.5	AAX52664.1