IGBP1 immunoglobulin (CD79A) binding protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: IGBP1provided by HGNC
Official Full Name: immunoglobulin (CD79A) binding protein 1provided by HGNC
Primary source: HGNC:5461
Locus tag: RP13-46G5.1
See related: Ensembl:ENSG00000089289; HPRD:02140; MIM:300139; Vega:OTTHUMG00000021767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IBP1; ALPHA-4
Summary: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: Xq13.1-q13.3

Sequence :: Chromosome: X; NC_000023.10 (69353318..69386174)

See IGBP1 in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

alpha4 is highly expressed in carcinogen-transformed human cells and primary human cancers.
Title: α4 is highly expressed in carcinogen-transformed human cells and primary human cancers.
both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation.
Title: The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.
IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome.
Title: Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance.
Data show that in addition to PP2Ac, alpha4 interacts with EDD and PABP, suggesting its involvement in multiple steps in the mTOR pathway that leads to translation initiation and cell-cycle progression.
Title: alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
a new role for mTOR and alpha4/PP2Ac in the control of STAT1 nuclear content, and the expression of interferon-gamma-sensitive genes involved in immunity and apoptosis.
Title: Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion.
alpha4 C-terminal deletion mutants at 222 (alpha4Delta222), 236 (alpha4Delta236) & 254 (alpha4Delta254) were expressed. alpha4Delta222 & alpha4Delta236 possess a higher content of alpha-helix, indicating that C-terminal region is less structured.
Title: Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42.
Alpha 4, a regulatory subunit of PP2-type phosphatases and a key component of the rapamycin-sensitive signaling pathway, has been indentified as a strong interactor of both MID1 and MID2.
Title: MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.

Submit: New GeneRIF Correction

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia

MIM: 300472

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Products	Interactant	Other Gene	Source	Pubs	Description
P78318	O15344	MID1	HPRD	PubMed
P78318	Q9UJV3	MID2	HPRD	PubMed
P78318	Protein phosphatase 2A, catalytic subunit, alpha isoform	PPP2CA	HPRD	PubMed
P78318	P60510	PPP4C	HPRD	PubMed
P78318	O00743	PPP6C	HPRD	PubMed
BioGRID:109698	BioGRID:115827	CCT2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:113054	CCT3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:115826	CCT4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:116603	CCT5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:107346	CCT6A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:115825	CCT7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:115933	CCT8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:198565	Cct3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:110427	MID1	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:109698	BioGRID:116231	MID2	BioGRID	PubMed	Co-localization
BioGRID:109698	BioGRID:111507	PPP2CA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109698	BioGRID:111508	PPP2CB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:111523	PPP4C	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:109698	BioGRID:111529	PPP6C	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109698	BioGRID:112810	TCP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109698	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein phosphatase type 2A regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
B cell activation	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein dephosphorylation	IEA Inferred from Electronic Annotation more info
negative regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of dephosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
regulation of microtubule-based movement	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of signal transduction	IEA Inferred from Electronic Annotation more info
response to interleukin-1	IMP Inferred from Mutant Phenotype more info	PubMed
response to tumor necrosis factor	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: immunoglobulin-binding protein 1

Names: immunoglobulin-binding protein 1; protein alpha-4; CD79a-binding protein 1; renal carcinoma antigen NY-REN-16; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; protein phosphatase 2A, regulatory subunit alpha-4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) )

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012084.1 RefSeqGene

Range

5001..37857

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001551.2 → NP_001542.1 immunoglobulin-binding protein 1

Status: REVIEWED

Source sequence(s)

BC004137

Consensus CDS

CCDS14396.1

UniProtKB/Swiss-Prot

P78318

Related

ENSP00000348784, OTTHUMP00000023465, ENST00000356413, OTTHUMT00000057053

Conserved Domains (1) summary

pfam04177
Location:12 – 329
Blast Score: 717

TAP42; TAP42-like family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

69353318..69386174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

63174076..63207564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL139111.20	CAI41587.1
genomic	AL158141.14	CAD13488.2
genomic	CH471132.2	EAX05355.1
		EAX05356.1
genomic	EF064724.1	ABK41907.1
mRNA	AK054596.1	BAG51396.1
mRNA	AK315660.1	BAG38026.1
mRNA	BC004137.2	AAH04137.1
mRNA	BT006736.1	AAP35382.1
mRNA	CR456782.1	CAG33063.1
mRNA	Y08915.1	CAA70119.1
other-genetic	DQ892322.2	ABM83248.1
other-genetic	DQ895524.2	ABM86450.1