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OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 347169, updated on 4-May-2015
Official Symbol
OR1B1provided by HGNC
Official Full Name
olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:8181
See related
Ensembl:ENSG00000171484; Ensembl:ENSG00000280094; HPRD:14913; Vega:OTTHUMG00000020616
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR9-B; OR9-26
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
See OR1B1 in MapViewer
Location:
9q33.2
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (122628579..122629535, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125390858..125391814, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor, family 1, subfamily J, member 2 Neighboring gene olfactory receptor, family 1, subfamily L, member 8 Neighboring gene olfactory receptor, family 1, subfamily N, member 2 Neighboring gene olfactory receptor, family 1, subfamily Q, member 1 Neighboring gene olfactory receptor, family 1, subfamily H, member 1 pseudogene Neighboring gene olfactory receptor, family 1, subfamily L, member 1 Neighboring gene olfactory receptor, family 1, subfamily L, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
    Olfactory Signaling Pathway, organism-specific biosystemMammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) th...
  • Olfactory transduction, organism-specific biosystem (from KEGG)
    Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Olfactory transduction, conserved biosystem (from KEGG)
    Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
detection of chemical stimulus involved in sensory perception IBA
Inferred from Biological aspect of Ancestor
more info
 
detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
olfactory receptor 1B1
Names
olfactory receptor 1B1
olfactory receptor 9-B
olfactory receptor OR9-26

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004450.1NP_001004450.1  olfactory receptor 1B1

    See identical proteins and their annotated locations for NP_001004450.1

    Status: PROVISIONAL

    Source sequence(s)
    BK004229
    Consensus CDS
    CCDS35126.1
    UniProtKB/Swiss-Prot
    Q8NGR6
    Related
    ENSP00000303151, ENST00000304833
    Conserved Domains (2) summary
    pfam00001
    Location:49296
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13853
    Location:143289
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    122628579..122629535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    125538797..125539753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)