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QRFP pyroglutamylated RFamide peptide [ Homo sapiens (human) ]

Gene ID: 347148, updated on 26-Jun-2015
Official Symbol
QRFPprovided by HGNC
Official Full Name
pyroglutamylated RFamide peptideprovided by HGNC
Primary source
See related
Ensembl:ENSG00000188710; HPRD:17813; MIM:609795
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P518; 26RFa
The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide peptides share a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors (Jiang et al., 2003 [PubMed 12714592]).[supplied by OMIM, Mar 2008]
See QRFP in Epigenomics, MapViewer
Exon count:
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (130893428..130893838, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133768815..133769225, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37 pseudogene 17 Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene uncharacterized LOC105376296 Neighboring gene fibrinogen C domain containing 1 Neighboring gene uncharacterized LOC105376297

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystem (from REACTOME)
    Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystemThe orphan G protein-coupled receptors mentioned here regulate sleep and appetite.
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...



Clone Names

  • MGC119794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
orexigenic neuropeptide QRFP receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
Process Evidence Code Pubs
grooming behavior IEA
Inferred from Electronic Annotation
more info
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
extracellular region TAS
Traceable Author Statement
more info
Preferred Names
orexigenic neuropeptide QRFP
orexigenic neuropeptide QRFP
P518 precursor protein
RF(Arg-Phe)amide family 26 amino acid peptide (P518)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198180.1NP_937823.1  orexigenic neuropeptide QRFP preproprotein

    See identical proteins and their annotated locations for NP_937823.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    ENSP00000345487, ENST00000343079
    Conserved Domains (1) summary
    RFamide_26RFa; Orexigenic neuropeptide Qrfp/P518

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1


  1. NC_018920.2 Alternate CHM1_1.1

    GenBank, FASTA, Sequence Viewer (Graphics)