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    STRA8 stimulated by retinoic acid 8 [ Homo sapiens (human) ]

    Gene ID: 346673, updated on 21-Mar-2013
    Official Symbol
    STRA8provided by HGNC
    Official Full Name
    stimulated by retinoic acid 8provided by HGNC
    Primary source
    HGNC:30653
    See related
    Ensembl:ENSG00000146857; HPRD:18123; MIM:609987; Vega:OTTHUMG00000155415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
    Location :
    7q33
    Sequence :
    Chromosome: 7; NC_000007.13 (134916731..134943244)
    See STRA8 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene transmembrane protein 140 Neighboring gene chromosome 7 open reading frame 49 Neighboring gene WD repeat domain 91 Neighboring gene solute carrier family 23 (nucleobase transporters), member 4, pseudogene Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene succinate dehydrogenase complex, subunit D, integral membrane protein pseudogene 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. Le Bouffant R, et al. Hum Reprod, 2010 Oct. PMID 20670969.
    2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Aston KI, et al. Hum Reprod, 2010 Jun. PMID 20378615.
    3. [Genetics and male infertility]. Stouffs K, et al. Verh K Acad Geneeskd Belg, 2009. PMID 20088251.
    4. Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells. Chen B, et al. Asian J Androl, 2009 Sep. PMID 19734913.
    5. Global gene expression in the human fetal testis and ovary. Houmard B, et al. Biol Reprod, 2009 Aug. PMID 19369649.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Functional characterization of an homologous mouse gene.
      Title: Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
    3. Expression restricted to testis (STRA8)
      Title: Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    female meiosis sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    meiotic DNA double-strand break formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    meiotic DNA replication checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    meiotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    oocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapsis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    stimulated by retinoic acid gene 8 protein homolog
    Names
    stimulated by retinoic acid gene 8 protein homolog
    stimulated by retinoic acid 8 homolog
    stimulated by retinoic acid gene 8 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182489.1 → NP_872295.1  stimulated by retinoic acid gene 8 protein homolog

      Status: REVIEWED

      Source sequence(s)
      AF513502
      Consensus CDS
      CCDS5839.1
      UniProtKB/Swiss-Prot
      Q7Z7C7
      Related
      ENSP00000275764, OTTHUMP00000207988, ENST00000275764, OTTHUMT00000340028

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p10 Primary Assembly

      Range
      134916731..134943244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      129219343..129246174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      134261076..134287597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018918.1 Alternate CHM1_1.0

      Range
      138280688..138307207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AACC02000025.1 (4089940..4116461) None
    genomic ABBA01001114.1 (24892..35174) None
    genomic ABBA01001115.1 None
    genomic AC009542.2 (78108..104621) None
    genomic AMYH01017955.1 (132070..158589) None
    genomic CH236950.1 EAL24061.1
    genomic CH471070.1 EAW83846.1
    mRNA AF513502.1 AAP47163.1
    other-genetic AB464251.1 BAG73764.1
    other-genetic BC141427.1 AAI41428.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7C7.1 GenPept UniProtKB/Swiss-Prot:Q7Z7C7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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