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eRF3 eukaryotic translation release factor 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34658, updated on 4-Apr-2024

Summary

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Official Symbol
eRF3provided by FlyBase
Official Full Name
eukaryotic translation release factor 3provided by FlyBase
Primary source
FLYBASE:FBgn0020443
Locus tag
Dmel_CG6382
See related
AllianceGenome:FB:FBgn0020443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6382; delf; deRF3; Dmel\CG6382; dsup35; Dsup35; DSUP35; elf; Elf
Summary
Predicted to enable GTP binding activity; GTPase activity; and translation release factor activity. Involved in translational termination. Located in cytosol. Is expressed in several structures, including early extended germ band embryo; embryonic/larval digestive system; foregut primordium; presumptive embryonic/larval digestive system; and testis. Orthologous to several human genes including GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
33E4-33E5; 2-46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12434452..12441279)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12434452..12441279)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SR family splicing factor SC35 Neighboring gene Organic anion transporting polypeptide 33Ea Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of a Drosophila homolog of yeast Sup35p disrupts spindle assembly, chromosome segregation, and cytokinesis during male meiosis. Basu J, et al. Cell Motil Cytoskeleton, 1998. PMID 9556329
  2. Evolution of the eukaryotic translation termination system: origins of release factors. Inagaki Y, et al. Mol Biol Evol, 2000 Jun. PMID 10833194
  3. Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Chao AT, et al. Genetics, 2003 Oct. PMID 14573473, Free PMC Article
  4. Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure. Lu B, et al. Trends Cell Biol, 2020 Apr. PMID 32200806, Free PMC Article
  5. A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes. Harris D, et al. Genetics, 2003 Oct. PMID 14573476, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation termination factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation release factor 3
Names
CG6382-PA
CG6382-PB
CG6382-PC
CG6382-PD
Ef1alpha-like factor
eRF3-PA
eRF3-PB
eRF3-PC
eRF3-PD
eukaryotic release factor 3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12434452..12441279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273486.1 → NP_001260415.1  eukaryotic translation release factor 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260415.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91944, Q9VK85
    Conserved Domains (5) summary
    cd01883
    Location:197 → 416
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:191 → 619
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:12 → 28
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:424 → 505
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:511 → 617
    eRF3_C_III; C-terminal domain of eRF3

  2. NM_057911.4 → NP_477259.1  eukaryotic translation release factor 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91944, Q9VK85
    Related
    FBpp0079951
    Conserved Domains (5) summary
    cd01883
    Location:197 → 416
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:191 → 619
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:12 → 28
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:424 → 505
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:511 → 617
    eRF3_C_III; C-terminal domain of eRF3

  3. NM_001298945.1 → NP_001285874.1  eukaryotic translation release factor 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285874.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91944, Q9VK85
    Conserved Domains (5) summary
    cd01883
    Location:197 → 416
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:191 → 619
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:12 → 28
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:424 → 505
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:511 → 617
    eRF3_C_III; C-terminal domain of eRF3

  4. NM_001273487.1 → NP_001260416.1  eukaryotic translation release factor 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260416.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PD08
    Conserved Domains (4) summary
    cd01883
    Location:73 → 292
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:67 → 495
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    cd04089
    Location:300 → 381
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:387 → 493
    eRF3_C_III; C-terminal domain of eRF3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PD08 M9PD08
P91944 P91944
Q9VK85 Q9VK85

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