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ZFP57 ZFP57 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 346171, updated on 18-Jul-2015
Official Symbol
ZFP57provided by HGNC
Official Full Name
ZFP57 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:18791
See related
Ensembl:ENSG00000204644; MIM:612192; Vega:OTTHUMG00000031158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNDM1; ZNF698; C6orf40; bA145L22; bA145L22.2
Summary
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
Orthologs
See ZFP57 in Epigenomics, MapViewer
Location:
6p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (29672392..29681146, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29640169..29644931, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SUMO2 pseudogene 1 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene zinc finger, DHHC-type containing 20 pseudogene 1 Neighboring gene HLA complex group 4 pseudogene 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA methylation involved in embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression by genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear heterochromatin IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 57 homolog
Names
zfp-57
zinc finger protein 698

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013045.1 RefSeqGene

    Range
    5001..9763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001109809.2NP_001103279.2  zinc finger protein 57 homolog

    See identical proteins and their annotated locations for NP_001103279.2

    Status: REVIEWED

    Source sequence(s)
    BC157878, BC171888
    Consensus CDS
    CCDS43436.2
    UniProtKB/TrEMBL
    B7ZW61
    UniProtKB/Swiss-Prot
    Q9NU63
    Related
    ENSP00000418259, OTTHUMP00000215586, ENST00000488757, OTTHUMT00000355773
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    29672392..29681146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715087.2XP_006715150.1  

    See identical proteins and their annotated locations for XP_006715150.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]
  2. XM_011514570.1XP_011512872.1  

    See identical proteins and their annotated locations for XP_011512872.1

    UniProtKB/Swiss-Prot
    Q9NU63
    Related
    ENSP00000366080, OTTHUMP00000065879, ENST00000376883, OTTHUMT00000132460
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    938100..938841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    1158865..1167654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725487.1XP_006725550.1  

    See identical proteins and their annotated locations for XP_006725550.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]
  2. XM_006725485.1XP_006725548.1  

    See identical proteins and their annotated locations for XP_006725548.1

    UniProtKB/Swiss-Prot
    Q9NU63
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]
  3. XM_011547249.1XP_011545551.1  

    See identical proteins and their annotated locations for XP_011545551.1

    UniProtKB/Swiss-Prot
    Q9NU63
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]
  4. XM_011547248.1XP_011545550.1  

    See identical proteins and their annotated locations for XP_011545550.1

    UniProtKB/Swiss-Prot
    Q9NU63
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]

Reference GRCh38.p2 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

    Range
    937938..946655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725701.1XP_006725764.1  

    See identical proteins and their annotated locations for XP_006725764.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]

Reference GRCh38.p2 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p2 ALT_REF_LOCI_4

    Range
    937506..946222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725818.1XP_006725881.1  

    See identical proteins and their annotated locations for XP_006725881.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]

Reference GRCh38.p2 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

    Range
    937766..946517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725910.2XP_006725973.1  

    See identical proteins and their annotated locations for XP_006725973.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]
  2. XM_011548049.1XP_011546351.1  

    See identical proteins and their annotated locations for XP_011546351.1

    UniProtKB/Swiss-Prot
    Q9NU63
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]

Reference GRCh38.p2 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

    Range
    937893..946610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006726000.1XP_006726063.1  

    See identical proteins and their annotated locations for XP_006726063.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    981424..990176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006726093.2XP_006726156.1  

    See identical proteins and their annotated locations for XP_006726156.1

    Conserved Domains (4) summary
    COG5048
    Location:113358
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:187209
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145168
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:133153
    ZF_C2H2; Zn binding site [ion binding]
  2. XM_011548432.1XP_011546734.1  

    See identical proteins and their annotated locations for XP_011546734.1

    UniProtKB/Swiss-Prot
    Q9NU63
    Conserved Domains (6) summary
    cd07765
    Location:4482
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:44104
    KRAB; krueppel associated box
    COG5048
    Location:185430
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:259281
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:217240
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:205225
    ZF_C2H2; Zn binding site [ion binding]

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    29642261..29647014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)