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    IFNAR2 interferon (alpha, beta and omega) receptor 2 [ Homo sapiens (human) ]

    Gene ID: 3455, updated on 18-May-2013
    Official Symbol
    IFNAR2provided by HGNC
    Official Full Name
    interferon (alpha, beta and omega) receptor 2provided by HGNC
    Primary source
    HGNC:5433
    See related
    Ensembl:ENSG00000159110; HPRD:03850; MIM:602376; Vega:OTTHUMG00000065127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFN-R; IFNABR; IFNARB; IFN-alpha-REC
    Summary
    The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    21q22.11
    Sequence :
    Chromosome: 21; NC_000021.8 (34602231..34636827)
    See IFNAR2 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene oligodendrocyte transcription factor 1 Neighboring gene chromosome 21 open reading frame 54 Neighboring gene IL10RB antisense RNA 1 (head to head) Neighboring gene interleukin 10 receptor, beta

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. Lin CW, et al. J Drug Target, 2012 Jul. PMID 22632162.
    2. Interferon (alpha, beta and omega) receptor 2 is a prognostic biomarker for lung cancer. Tanaka S, et al. Pathobiology, 2012. PMID 22236545.
    3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    4. Stochastic receptor expression determines cell fate upon interferon treatment. Levin D, et al. Mol Cell Biol, 2011 Aug. PMID 21690295.
    5. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, et al. PLoS One, 2010 Aug 25. PMID 20811626.

    See all (87) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. IFNAR2 overexpression was observed in various histological types of lung cancer, and appears to be associated with lung cancers that behave aggressively.
      Title: Interferon (alpha, beta and omega) receptor 2 is a prognostic biomarker for lung cancer.
    2. A low number of receptors suffices for antiviral response and is thus a robust feature common to all cells. Conversely, a high number of receptors is required for antiproliferative activity, which allows for fine-tuning on a single-cell level.
      Title: Stochastic receptor expression determines cell fate upon interferon treatment.
    3. IFNAR1 (interferon-alpha receptor 1) (G/C in SNP18417) and IFNAR1 (interferon-alpha receptor 2) (G/T in SNP 11876) polymorphisms jointly, but not individually, may confer susceptibility to Behcets disease in a Turkish population
      Title: IFNAR1 and IFNAR2 polymorphisms in patients with Behçet's disease.
    4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
    5. The IFNAR2-8SS genotype was associated with HBeAg negative patients; IFNAR2-8F allele was associated with the risk to high viral loads; the IFNAR2-8FF genotype predisposed to higher MxA gene induction and correlated with sustained IFN response.
      Title: Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection.
    6. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.
    7. Results suggest that zinc, especially polaprezinc, enhances the expression of type 1 interferon 2 receptor in U937 cells, thereby inducing production of the anti-viral protein 2'-5'OAS.
      Title: Induction of type 1 interferon receptor by zinc in U937 cells.
    8. Defective monocyte responses to IFNalpha/beta may play an important role in the pathogenesis of HIV-1 infection, and decreased IFNalpha/betaR expression may serve as a novel marker of disease progression.
      Title: Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression.
    9. Ep-CAM is a potentially useful marker for resistance to INFalpha/5-FU therapy, especially in IFNAR2-positive cases.
      Title: Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma.
    10. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.
    Submit: New GeneRIF Correction See all (38)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Tat, p14 tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of interferon (alpha, beta and omega) receptor 2 (IFNAR2) in U-937 macrophages PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_997468.1 NP_006089.1 GNB2L1    BIND  PubMed IFNR-beta-L interacts with RACK-1. 
    NP_997468.1 NP_002218.1 JAK1    BIND  PubMed IFNR-beta-L interacts with Jak1. 
    NP_997468.1 NP_003322.2 TYK2    BIND  PubMed IFNR-beta-L interacts with Tyk2. 
    P48551 P63244 GNB2L1    HPRD  PubMed  
    P48551 P01563 IFNA2    HPRD  PubMed  
    P48551 P01569 IFNA5    HPRD  PubMed  
    P48551 P32881 IFNA8    HPRD  PubMed  
    P48551 P17181 IFNAR1    HPRD  PubMed  
    P48551 P01574 IFNB1    HPRD  PubMed  
    P48551 P23458 JAK1    HPRD  PubMed  
    P48551 P05771 PRKCB    HPRD  PubMed  
    P48551 P42224 STAT1    HPRD  PubMed  
    P48551 P52630 STAT2    HPRD  PubMed  
    P48551 P40763 STAT3    HPRD  PubMed  
    P48551 P29597 TYK2    HPRD  PubMed  
    P48551 Q9UMW8 USP18    HPRD  PubMed  
    BioGRID:109677 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109677 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109677 BioGRID:109663 IFNA2    BioGRID  PubMed Co-purification; Reconstituted Complex 
    BioGRID:109677 BioGRID:109677 IFNAR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109677 BioGRID:115652 IRF9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109677 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109677 BioGRID:122786 PPP1R3B    BioGRID  PubMed Two-hybrid 
    BioGRID:109677 BioGRID:112649 STAT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109677 BioGRID:112650 STAT2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109677 BioGRID:116430 USP18    BioGRID  PubMed Affinity Capture-Western 
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
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    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Hepatitis C, organism-specific biosystem (from KEGG)
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    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
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    • Influenza A, conserved biosystem (from KEGG)
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    • Interferon Signaling, organism-specific biosystem (from REACTOME)
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    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
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    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
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      Regulation of Telomerase
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    Markers

    Genotypes

    Potential readthrough

    Included gene: IL10RB

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    type I interferon binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    type I interferon receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    interferon alpha/beta receptor 2
    Names
    interferon alpha/beta receptor 2
    IFN-R-2
    IFN-alpha binding protein
    IFN-alpha/beta receptor 2
    type I interferon receptor 2
    interferon alpha binding protein
    human interferon alpha/beta receptor
    interferon-alpha/beta receptor beta chain

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016003.1 RefSeqGene

      Range
      5001..39597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000874.3 → NP_000865.2  interferon alpha/beta receptor 2 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      BG715143, BI520056, BM677386, L41944
      Consensus CDS
      CCDS13622.1
      UniProtKB/Swiss-Prot
      P48551
      Conserved Domains (3) summary
      pfam01108
      Location:13 – 118
      Blast Score: 205
      Tissue_fac; Tissue factor
      pfam09294
      Location:134 – 231
      Blast Score: 145
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      pfam13900
      Location:296 – 329
      Blast Score: 112
      GVQW; Putative binding domain

    2. NM_207584.1 → NP_997467.1  interferon alpha/beta receptor 2 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      BC002793, BG715143, BI520056, BM677386, L41944
      Consensus CDS
      CCDS13622.1
      UniProtKB/Swiss-Prot
      P48551
      UniProtKB/TrEMBL
      Q9BUA0
      Related
      ENSP00000371699, OTTHUMP00000067676, ENST00000382264, OTTHUMT00000139827
      Conserved Domains (3) summary
      pfam01108
      Location:13 – 118
      Blast Score: 205
      Tissue_fac; Tissue factor
      pfam09294
      Location:134 – 231
      Blast Score: 145
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      pfam13900
      Location:296 – 329
      Blast Score: 112
      GVQW; Putative binding domain

    3. NM_207585.1 → NP_997468.1  interferon alpha/beta receptor 2 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC013156, BG715143, BI520056, U29584, X89814
      Consensus CDS
      CCDS13621.1
      UniProtKB/Swiss-Prot
      P48551
      Related
      ENSP00000371676, ENST00000382241
      Conserved Domains (2) summary
      pfam01108
      Location:13 – 118
      Blast Score: 211
      Tissue_fac; Tissue factor
      pfam09294
      Location:134 – 231
      Blast Score: 149
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p10 Primary Assembly

      Range
      34602231..34636827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      20067860..20102189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018932.1 Alternate CHM1_1.0

      Range
      25149041..25183689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01057334.1 (23746..32275) None
    genomic ABBA01057335.1 None
    genomic ABBA01057336.1 None
    genomic AMYH01012208.1 (52730..65528) None
    genomic AMYH01012209.1 None
    genomic AP000292.1 (33140..37451) None
    genomic AP000293.1 None
    genomic AP000294.1 None
    genomic AP000295.1 None
    genomic AY740397.1 AAU21038.1
    genomic CH471079.2 EAX09842.1
      EAX09843.1
      EAX09844.1
      EAX09845.1
      EAX09846.1
    genomic L42237.1 None
    genomic L42238.1 AAB46419.1
    genomic L42239.1 AAB46419.1
    genomic L42240.1 AAB46419.1
    genomic L42241.1 AAB46419.1
    genomic L42242.1 AAB46419.1
    genomic L42243.1 AAB46417.1
      AAB46418.1
    mRNA AK293059.1 BAF85748.1
    mRNA BC002793.2 AAH02793.1
    mRNA BC013156.1 None
    mRNA BG715143.1 None
    mRNA BI520056.1 None
    mRNA BM677386.1 None
    mRNA CR541817.1 CAG46616.1
    mRNA L41942.1 AAB46413.1
    mRNA L41943.1 AAB46414.1
    mRNA L41944.1 AAB46415.1
    mRNA U29584.1 AAC50202.1
    mRNA X77722.1 CAA54785.1
    mRNA X89772.1 CAA61914.1
    mRNA X89814.1 CAA61940.1
    other-genetic DQ893015.2 ABM83941.1
    other-genetic DQ896260.2 ABM87259.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48551.1 GenPept UniProtKB/Swiss-Prot:P48551

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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