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IFNAR2 interferon (alpha, beta and omega) receptor 2 [ Homo sapiens (human) ]

Gene ID: 3455, updated on 29-Jul-2014
Official Symbol
IFNAR2provided by HGNC
Official Full Name
interferon (alpha, beta and omega) receptor 2provided by HGNC
Primary source
HGNC:5433
See related
Ensembl:ENSG00000159110; HPRD:03850; MIM:602376; Vega:OTTHUMG00000065127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
Summary
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See IFNAR2 in Epigenomics, MapViewer
Location:
21q22.11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 21 NC_000021.9 (33229895..33264513)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34602231..34636831)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928107 Neighboring gene chromosome 21 open reading frame 54 Neighboring gene IL10RB antisense RNA 1 (head to head) Neighboring gene interleukin 10 receptor, beta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hepatitis b virus, susceptibility to
MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of interferon (alpha, beta and omega) receptor 2 (IFNAR2) in U-937 macrophages PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    Downstream signaling in naive CD8+ T cells, organism-specific biosystem
    Downstream signaling in naive CD8+ T cells
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
    Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
  • Interferon type I, organism-specific biosystem (from WikiPathways)
    Interferon type I, organism-specific biosystemThe type I IFNs (IFN? family, IFN?, IFN?, IFN? and IFN?) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Regulation of IFNA signaling, organism-specific biosystem (from REACTOME)
    Regulation of IFNA signaling, organism-specific biosystemThere are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation...
  • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Telomerase, organism-specific biosystem
    Regulation of Telomerase
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: IL10RB

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
type I interferon binding IPI
Inferred from Physical Interaction
more info
PubMed 
type I interferon receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
 
response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
response to virus TAS
Traceable Author Statement
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
interferon alpha/beta receptor 2
Names
interferon alpha/beta receptor 2
IFN-R-2
IFN-alpha/beta receptor 2
type I interferon receptor 2
interferon alpha binding protein
human interferon alpha/beta receptor
interferon-alpha/beta receptor beta chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016003.1 

    Range
    4970..39588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000874.4NP_000865.2  interferon alpha/beta receptor 2 isoform b

    See proteins identical to NP_000865.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    BG715143, BM677386, HY104613, L41944
    Consensus CDS
    CCDS13622.1
    UniProtKB/Swiss-Prot
    P48551
    Conserved Domains (3) summary
    pfam01108
    Location:13118
    Blast Score: 209
    Tissue_fac; Tissue factor
    pfam09294
    Location:134227
    Blast Score: 149
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    pfam13900
    Location:296331
    Blast Score: 113
    GVQW; Putative binding domain
  2. NM_001289125.1NP_001276054.1  interferon alpha/beta receptor 2 isoform a

    See proteins identical to NP_001276054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 4 both encode isoform a.
    Source sequence(s)
    AP000295, HY104613, L41942
    UniProtKB/Swiss-Prot
    P48551
    Conserved Domains (2) summary
    pfam01108
    Location:13118
    Blast Score: 215
    Tissue_fac; Tissue factor
    pfam09294
    Location:134227
    Blast Score: 152
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  3. NM_001289126.1NP_001276055.1  interferon alpha/beta receptor 2 isoform c

    See proteins identical to NP_001276055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon, which results in a frameshift and early termination of translation, compared to variant 1. The encoded protein (isoform c) has a shorter and distinct C-terminus, compared to isoform a. Variants 5 and 6 both encode isoform c.
    Source sequence(s)
    AP000295, HY104613, L41943, X89814
    UniProtKB/Swiss-Prot
    P48551
    Conserved Domains (2) summary
    pfam01108
    Location:13118
    Blast Score: 211
    Tissue_fac; Tissue factor
    pfam09294
    Location:134227
    Blast Score: 147
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  4. NM_001289128.1NP_001276057.1  interferon alpha/beta receptor 2 isoform c

    See proteins identical to NP_001276057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon, which results in a frameshift and early termination of translation, compared to variant 1. The encoded protein (isoform c) has a shorter and distinct C-terminus, compared to isoform a. Variants 5 and 6 both encode isoform c.
    Source sequence(s)
    BC013156, CD110317, HY104613, U29584, X89814
    UniProtKB/Swiss-Prot
    P48551
    Conserved Domains (2) summary
    pfam01108
    Location:13118
    Blast Score: 211
    Tissue_fac; Tissue factor
    pfam09294
    Location:134227
    Blast Score: 147
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  5. NM_207584.2NP_997467.1  interferon alpha/beta receptor 2 isoform b

    See proteins identical to NP_997467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    BC002793, BG715143, BI520056, BM677386, HY104613, L41944
    Consensus CDS
    CCDS13622.1
    UniProtKB/Swiss-Prot
    P48551
    UniProtKB/TrEMBL
    Q9BUA0
    Related
    ENSP00000371699, OTTHUMP00000067676, ENST00000382264, OTTHUMT00000139827
    Conserved Domains (3) summary
    pfam01108
    Location:13118
    Blast Score: 209
    Tissue_fac; Tissue factor
    pfam09294
    Location:134227
    Blast Score: 149
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    pfam13900
    Location:296331
    Blast Score: 113
    GVQW; Putative binding domain
  6. NM_207585.2NP_997468.1  interferon alpha/beta receptor 2 isoform a

    See proteins identical to NP_997468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4 both encode isoform a.
    Source sequence(s)
    BC013156, BG715143, HY104613, U29584, X89814
    Consensus CDS
    CCDS13621.1
    UniProtKB/Swiss-Prot
    P48551
    Related
    ENSP00000371676, ENST00000382241
    Conserved Domains (2) summary
    pfam01108
    Location:13118
    Blast Score: 215
    Tissue_fac; Tissue factor
    pfam09294
    Location:134227
    Blast Score: 152
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000021.9 

    Range
    33229895..33264513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000153.1 

    Range
    20067829..20102180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 

    Range
    34164872..34199462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)