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CG6415 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34474, updated on 4-Apr-2024

Summary

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Official Symbol
CG6415provided by FlyBase
Primary source
FLYBASE:FBgn0032287
Locus tag
Dmel_CG6415
See related
AllianceGenome:FB:FBgn0032287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
151967_at; anon-32Aa; Dmel\CG6415
Summary
Predicted to enable aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval fat body; fat body primordium; and fat body/gonad primordium. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
32A4-32A4; 2-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10703621..10704930)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10703621..10704930)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44181 Neighboring gene uncharacterized protein Neighboring gene Lipase 1 Neighboring gene Lipase 2 Neighboring gene long non-coding RNA:CR44407 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
  2. Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Kristensen TN, et al. Genetics, 2006 Jul. PMID 16624914, Free PMC Article
  3. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Tufi R, et al. Nat Cell Biol, 2014 Feb. PMID 24441527, Free PMC Article
  4. Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Hoffmann J, et al. Aging (Albany NY), 2013 Apr. PMID 23765091, Free PMC Article
  5. Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. Riedl CA, et al. Behav Genet, 2005 May. PMID 15864439

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aminomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminomethyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine decarboxylation via glycine cleavage system ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6415-PA
NP_609441.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10703621..10704930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135597.3 → NP_609441.1  uncharacterized protein Dmel_CG6415 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609441.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BII9, Q9VKR4
    Related
    FBpp0079697
    Conserved Domains (3) summary
    PLN02319
    Location:3 → 403
    PLN02319; aminomethyltransferase
    pfam01571
    Location:31 → 288
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:298 → 392
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BII9 Q5BII9
Q95U61 Q95U61
Q9VKR4 Q9VKR4

Gene LinkOut

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