CDKL4 cyclin-dependent kinase-like 4 [Homo sapiens] - Gene

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Summary

Official Symbol: CDKL4provided by HGNC
Official Full Name: cyclin-dependent kinase-like 4provided by HGNC
Primary source: HGNC:19287
See related: Ensembl:ENSG00000205111; HPRD:16698; Vega:OTTHUMG00000133574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

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Genomic context

Location :: 2p22.1

Sequence :: Chromosome: 2; NC_000002.11 (39405688..39456673, complement)

See CDKL4 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cyclin-dependent kinase-like 4

Names: cyclin-dependent kinase-like 4

NP_001009565.1

EC 2.7.11.22

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009565.1 → NP_001009565.1 cyclin-dependent kinase-like 4

Status: PROVISIONAL

Source sequence(s)

AY845084

Consensus CDS

CCDS33184.1

UniProtKB/Swiss-Prot

Q5MAI5

Related

ENSP00000368080, OTTHUMP00000164944, ENST00000378803, OTTHUMT00000257676

Conserved Domains (2) summary

cd07847
Location:2 – 286
Blast Score: 1545

STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

pfam00069
Location:4 – 286
Blast Score: 744

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

39405688..39456673, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

39144443..39195833, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC079615.6 (34445..78387)	None
genomic	AC092672.3 (73478..80520)	None
genomic	CH471053.2	EAX00349.1
mRNA	AY845084.1	AAW30008.1
mRNA	AY847283.1	AAW31760.1
mRNA	BC144460.1	None
other-genetic	BC172293.1	AAI72293.1