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    RnrL Ribonucleoside diphosphate reductase large subunit [ Drosophila melanogaster ]

    Gene ID: 34392, updated on 10-May-2012
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    Summary

    Official Symbol
    RnrLprovided by Flybase
    Official Full Name
    Ribonucleoside diphosphate reductase large subunitprovided by Flybase
    Primary source
    FLYBASE:FBgn0011703
    Locus tag
    Dmel_CG5371
    Gene type
    protein coding
    RNA name
    ribonucleoside diphosphate reductase large subunit
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5371; Dmel\CG5371; DmRNR1; l(2)k06709; RNR1; RnrM1; RntL
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    Genomic context

    Location :
    31D8-31D8
    Sequence :
    Chromosome: 2L; NT_033779.4 (10325018..10327986, complement)
    See RnrL in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG4972 gene product from transcript CG4972-RA Neighboring gene CG5381 gene product from transcript CG5381-RA Neighboring gene CG4995 gene product from transcript CG4995-RB Neighboring gene CG5375 gene product from transcript CG5375-RB Neighboring gene CG5037 gene product from transcript CG5037-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Sun D, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818390.
    2. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764.
    3. Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins. McGraw LA, et al. Genetics, 2008 Jul. PMID 18562649.
    4. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    5. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:60477 BioGRID:63151 CG11275    BioGRID  PubMed Two-hybrid 
    BioGRID:60477 BioGRID:65551 CG4289    BioGRID  PubMed Two-hybrid 
    BioGRID:60477 BioGRID:70923 c(3)G    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the RnrL gene: The RnrL gene is conserved in human, chimpanzee, , dog, cow, mouse, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ribonucleoside-diphosphate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ribonucleoside-diphosphate reductase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication NAS
    Non-traceable Author Statement
    more info
    		  
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    ribonucleoside-diphosphate reductase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    CG5371 gene product from transcript CG5371-RA
    Names
    CG5371-PA
    RnrL-PA
    ribonucleoside diphosphate reductase M1 subunit
    ribonucleoside diphosphate reductase large subunit
    ribonucleoside-diphosphate reductase large subunit
    NP_477027.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      10325018..10327986, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057679.4 → NP_477027.1  ribonucleoside diphosphate reductase large subunit [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48591
      Related
      FBpp0079648, FBtr0080059
      Conserved Domains (3) summary
      cd01679
      Location:178 – 752
      Blast Score: 1880
      RNR_I; Class I ribonucleotide reductase
      PLN02437
      Location:12 – 812
      Blast Score: 3761
      PLN02437; ribonucleoside--diphosphate reductase large subunit
      pfam03477
      Location:12 – 100
      Blast Score: 191
      ATP-cone; ATP cone domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY119149.1 AAM51009.1
    mRNA AF132143.1 AAD33590.1
    genomic AE014134.5 AAF52913.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48591.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content