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CG5731 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34355, updated on 4-Apr-2024

Summary

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Official Symbol
CG5731provided by FlyBase
Primary source
FLYBASE:FBgn0032192
Locus tag
Dmel_CG5731
See related
AllianceGenome:FB:FBgn0032192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5731
Summary
Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
31B1-31B1; 2-40 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10207085..10209744, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10207085..10209744, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 17 Neighboring gene long non-coding RNA:CR44845 Neighboring gene uncharacterized protein Neighboring gene athos

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila mojavensis - chico. Congleton H, et al. MicroPubl Biol, 2022. PMID 36468157, Free PMC Article
  2. Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery. Rigon L, et al. Biomedicines, 2021 Mar 7. PMID 33800050, Free PMC Article
  3. Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. Garelli A, et al. Science, 2012 May 4. PMID 22556250
  4. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Bouché V, et al. Autophagy, 2016. PMID 26761346, Free PMC Article
  5. Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster. Appel M, et al. PLoS One, 2015. PMID 25992709, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5731-PA
NP_609354.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10207085..10209744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135510.3 → NP_609354.1  uncharacterized protein Dmel_CG5731 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MYY3, Q9VL27
    Related
    FBpp0079549
    Conserved Domains (1) summary
    cl07893
    Location:25 → 399
    AmyAc_family; Alpha amylase catalytic domain family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MYY3 Q8MYY3
Q9VL27 Q9VL27

Gene LinkOut

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