IFI27 interferon, alpha-inducible protein 27 [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: IFI27provided by HGNC
Official Full Name: interferon, alpha-inducible protein 27provided by HGNC
Primary source: HGNC:5397
See related: Ensembl:ENSG00000165949; HPRD:02479; MIM:600009; Vega:OTTHUMG00000171303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P27; ISG12; FAM14D; ISG12A

Genomic context

Go to the top of the page Help

Location :: 14q32

Sequence :: Chromosome: 14; NC_000014.8 (94577079..94583033)

See IFI27 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

After inhibiting the autophagy, the expression of interferon b1 and IFI27 were decreased.
Title: [Effect of autophagy on expression of interferon in hepatitis B virus-infected hepatocytes].
Patients with atypical teratoid/rhabdoid tumors show high p27 expression when angiogenesis and density of newly formed blood vessels were investigated.
Title: Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors.
interferon alpha-inducible protein 27 (IFI27) transcription stimulation was weaker in leiomyoma than myometrial cells
Title: Interferon-inducible genes, TNF-related apoptosis-inducing ligand (TRAIL) and interferon inducible protein 27 (IFI27) are negatively regulated in leiomyomas: implications for a role of the interferon pathway in leiomyoma development.
Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors.
Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.
IFI27 may be a novel biomarker of disease activity and tumor burden in patients with chronic myeloproliferative neoplasms
Title: Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis.
We identify IFI27, CCL2 and CXCL10 as sensitive biomarkers for the response of multiple sclerosis patients to IFN-beta.
Title: Identification of new sensitive biomarkers for the in vivo response to interferon-beta treatment in multiple sclerosis using DNA-array evaluation.
five genes (TNFSF10/TRAIL, IL1RN, IFI27, GZMB, and CCR5) were upregulated and three genes (CLK1, TNFAIP3 and BTG1) were downregulated in at least three out of four subpopulations during acute GVHD.
Title: Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation.
REsults describe the differential regulation of the interferon induced gene ISG12A by serum from healthy and preeclamptic pregnancies.
Title: Differential regulation of the interferon induced gene ISG12A by serum from healthy and preeclamptic pregnancies.
data suggest that ISG12a contributes to IFN-dependent perturbation of normal mitochondrial function, thus adding ISG12a to a growing list of IFN-induced proteins that impact cellular apoptosis.
Title: Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Submit: New GeneRIF Correction See all (12)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Go to the top of the page Help

Protein	Gene	Interaction	Pubs
Tat, p14	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI27, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
P40305	P24385	CCND1	HPRD	PubMed
P40305	P11802	CDK4	HPRD	PubMed
BioGRID:109655	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109655	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...

General gene information

Go to the top of the page Help

Homology

Homologs of the IFI27 gene: The IFI27 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	NAS Non-traceable Author Statement more info
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: interferon alpha-inducible protein 27, mitochondrial

Names: interferon alpha-inducible protein 27, mitochondrial; ISG12(a); 2310061N23Rik; interferon-stimulated gene 12a protein; interferon alpha-induced 11.5 kDa protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130080.1 → NP_001123552.1 interferon alpha-inducible protein 27, mitochondrial isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). This variant represents an allele commonly found in the human population, and corresponds to the allele present in the Celera and HuRef assemblies.

Source sequence(s)

AI799552, AU103232, BN000227

UniProtKB/TrEMBL

A8K0H0

UniProtKB/Swiss-Prot

P40305

Conserved Domains (1) summary

pfam06140
Location:78 – 104
Blast Score: 74

Ifi-6-16; Interferon-induced 6-16 family
NM_005532.3 → NP_005523.3 interferon alpha-inducible protein 27, mitochondrial isoform 2

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) represents an alternate allele that lacks a 9-nt segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal 3 aa segment and differs at two adjacent aa, as compared to isoform 1. This variant represents a second allele commonly found in the human population, and corresponds to the allele present in the reference assembly.

Source sequence(s)

AI799552, AK097084, BC015492, BU601451, CB993374

Consensus CDS

CCDS32148.1

UniProtKB/Swiss-Prot

P40305

Related

ENSP00000298902, OTTHUMP00000245780, ENST00000298902, OTTHUMT00000412886

Conserved Domains (1) summary

pfam06140
Location:45 – 101
Blast Score: 84

Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p10 Primary Assembly

Range

94577079..94583033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

74756896..74762859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018925.1 Alternate CHM1_1.0

Range

75567120..75573074

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01030420.1 (13154..19117)	None
genomic	AL079302.7 (196069..196082)	None
genomic	AL121838.4 (2..5942)	None
genomic	AMYH01005968.1 (331306..337260)	None
genomic	CH471061.1	EAW81556.1
		EAW81557.1
		EAW81558.1
genomic	FB659850.1	CAS01779.1
mRNA	AI799552.1	None
mRNA	AJ294851.2	CAC10503.2
mRNA	AK095039.1	None
mRNA	AK097084.1	None
mRNA	AK289535.1	BAF82224.1
mRNA	AK312089.1	BAG35025.1
mRNA	AU103232.1	None
mRNA	AY126456.1	AAM95743.1
mRNA	AY126457.1	AAM95744.1
mRNA	AY126458.1	AAM95745.1
mRNA	BC015492.1	AAH15492.1
mRNA	BN000227.1	CAE00394.1
mRNA	BT006781.1	AAP35427.1
mRNA	BU601451.1	None
mRNA	BX647330.1	None
mRNA	CB993374.1	None
mRNA	X67325.1	CAA47739.1
other-genetic	AM393107.1	CAL37985.1
other-genetic	AM393779.1	CAL38654.1
other-genetic	DQ893816.2	ABM84742.1