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IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial [ Homo sapiens (human) ]

Gene ID: 3418, updated on 24-Aug-2015
Official Symbol
IDH2provided by HGNC
Official Full Name
isocitrate dehydrogenase 2 (NADP+), mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:5383
See related
Ensembl:ENSG00000182054; HPRD:00973; MIM:147650; Vega:OTTHUMG00000149815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH
Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Orthologs
See IDH2 in Epigenomics, MapViewer
Location:
15q26.1
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (90083978..90102554, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90626283..90645730, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5A pseudogene Neighboring gene zinc finger protein 710 Neighboring gene microRNA 3174 Neighboring gene uncharacterized LOC105370966 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B Neighboring gene ribosomal protein S12 pseudogene 26

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of isocitrate dehydrogenase 2 (IDH2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
isocitrate dehydrogenase (NADP+) activity EXP
Inferred from Experiment
more info
 
isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
isocitrate dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
cellular metabolic process TAS
Traceable Author Statement
more info
 
glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
 
isocitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
isocitrate dehydrogenase [NADP], mitochondrial
Names
NADP(+)-specific ICDH
oxalosuccinate decarboxylase
NP_001276839.1
NP_001277043.1
NP_002159.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023302.1 RefSeqGene

    Range
    4923..23499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_611

mRNA and Protein(s)

  1. NM_001289910.1NP_001276839.1  isocitrate dehydrogenase [NADP], mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001276839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK294148, BC009244
    Consensus CDS
    CCDS76792.1
    UniProtKB/Swiss-Prot
    P48735
    Related
    ENSP00000446147, OTTHUMP00000247941, ENST00000540499, OTTHUMT00000417509
    Conserved Domains (1) summary
    PTZ00435
    Location:1399
    PTZ00435; isocitrate dehydrogenase; Provisional
  2. NM_001290114.1NP_001277043.1  isocitrate dehydrogenase [NADP], mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001277043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK299987, HY010337, X69433
    UniProtKB/TrEMBL
    B4DSZ6
    UniProtKB/Swiss-Prot
    P48735
    Conserved Domains (1) summary
    cl00445
    Location:1321
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
  3. NM_002168.3NP_002159.2  isocitrate dehydrogenase [NADP], mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_002159.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK312627, HY010337, X69433
    Consensus CDS
    CCDS10359.1
    UniProtKB/Swiss-Prot
    P48735
    Conserved Domains (1) summary
    PTZ00435
    Location:39451
    PTZ00435; isocitrate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    90083978..90102554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    90468783..90487361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)